Insulin and gyno?

[Muselz]

Can insulin use cause gyno?

[Etil]

im pretty sure it cant, gyno comes from to much estrogen i think...Which is why its common when you use steroids and dont have enought anti estrogen..Insulin doesnt affect this now does it?

[Muselz]

any further input, anyone?

[Slide]

I have never heard of it, nor could I think of a pathway that it could.

Insulin can cause weight gain, which can cause pseudo-gyno, but not actual gland growth. The glands growth is due to hormones such as estrogen, prolactin, and progesterone.

[Muselz]

I have never heard of it, nor could I think of a pathway that it could.

Insulin can cause weight gain, which can cause pseudo-gyno, but not actual gland growth. The glands growth is due to hormones such as estrogen, prolactin, and progesterone.

Thanks!

[jimmyinkedup]

isulin COULD in theory aggravate but not cause gyno. Increase in IGF ......

[legobricks]

isulin COULD in theory aggravate but not cause gyno. Increase in IGF ......

^^^ Yes exactly. If you already have pre-existing gyno, many things can aggrivate it and cause growth. Estrogen and the like are not the only things.

[Muselz]

^^^ Yes exactly. If you already have pre-existing gyno, many things can aggrivate it and cause growth. Estrogen and the like are not the only things.

interesting..

[Deep_Fried]

isulin COULD in theory aggravate but not cause gyno. Increase in IGF ......

Let me elaborate and minor correction...

The IGF receptor pathway signaling is not significant to primary mammary development/growth.

The 3 regulatory hormones that balance the different primary phases of mammary proliferation/differentiation are Prolactin, Estrogen, and Progesterone.

OK, here is the way Insulin can possibly can have effect.

Insulin levels are clinically recognized to reduce SHBG and thus known to be inversely proportional to circulation SHBG levels.

Lower SHBG can contribute to higher Free T. BUT! Higher free T footprint is also fuel for unchecked Aromatase to allow for a greater E2.

So, in short, if Insulin is high and Aromatase ratio is high in certain sensitive individuals, possible higher E2 can be the result leading to gyno symptoms.

[nonotone]

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[Deep_Fried]

Good thinking!, but this relationship between insulin and shbg is related to obesity, higher fat mass --> higher insulin and higher fat mass --> lower shbg, even if insulin levels were directly inversely proportional to shbg levels the equilibrium between shbg and testosterone consentration works as a buffer keeping the free t levels pretty much constant.
In theory oscillations in free t levels significant enough to raise estrogen levels could accelerate the growth of pre-existing glandular tissue.. but injecting insulin into would not be able to cause this, so in vivo that just would not happen.

In other words - nothing to worry about

I am talking about the possible imbalances caused by exogenous hormone manipulation regarding exo insulin.

You, on the other hand, are discussing the body's natural tendencies with regards to endogenous hormone equilibrium per the particular observed studies you are drawing generalizations. I do understand and agree on this part.

Obesity induced Insulin Resistance, however, is not a concern (as far as a contributing factor) in this case, when unchecked exo insulin protocols can not only reproduce this environment, but cause even greater fluctuations than the body could ever produce naturally. All depending on many other factors such as dosage alterations and protocol length.

My point is merely that the possibility exists, with exogenous hormone manipulation, among other factors that the OP has not divulged about his personal stats, such as BF, or Bloodwork.

Truly, much more info is needed to even support much of my speculation.

[nonotone]

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[nonotone]

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