ghrp-6

[warchild1721]

Seems after a bit of searching there's mixed opinions which are great to have but im a lot more comfortable with the ppl on these forums than others. Here's my boggle....


5mg vial--how much BW. I've seen 2.5 and 3ml as recommendations. Need to know if you guys think these are accurate. Secondly.....

Shooting 250-300 into the rat daily. Im no math wiz so how many shots per vial would that be?

Even just little help on this would go along way.

[DCannon]

I'd add 2.5 ml, it makes the math easier. This way you have 2.5mg/ml

5mg=5000mcg
5000mcg/250mcg = 20 shots per vial
5000mcg/300mcg = 16.6 shots per vial

[warchild1721]

This is the best post by far! Simple answer and I appreciate that alot. What do you know about the BW and sodium chloride that comes with it? Some pick and choose between the two. Im leaning towards bw.

[DCannon]

This is the best post by far! Simple answer and I appreciate that alot. What do you know about the BW and sodium chloride that comes with it? Some pick and choose between the two. Im leaning towards bw.

Go with the bac water because it will prevent the growth of bacteria just incase. Sodium chloride won't do that.

[warchild1721]

Wut awaste to put it in my package then lol anyway im gonna be keeping a log of my shit to measure if ghrp-6 is effective in any way. If you care for the results and or anyone else for that matter just let me know. Don't see many straight fwd log of this stuff. No before and after stats or pics so along with helping this giant 200 pound 26 yr old rat maybe someone else out there can use this info.

Thanks dcannon for helping on this thread

[DCannon]

No problem warchild, I'm looking forward to seeing your log.

[warchild1721]

Put 2.5 pins in 5mg vial...it almost doesn't look like enough for 20 shots. Its a 100 unit 1ml slin pin. Tthoughts?

[DCannon]

Put 2.5 pins in 5mg vial...it almost doesn't look like enough for 20 shots. Its a 100 unit 1ml slin pin. Tthoughts?

Every 10 mark on your slin pin (or 0.1ml) is 200mcg. It doesn't take very much water.

[warchild1721]

Sweet. Tomorrow will be day one. I will keep you updated. Thanks bro

[warchild1721]

I cheated and started last night. Did 200mcg before bed and again this morning. Not sure about the hunger. Was a bit hungry already but pretty much thought about food for the first hour. This morning I had stronger appetite. Noticed. Stomach grinning and bit of extra gas. Had no time for eggs. Grabbed a pop tart and yogurt for breakfast. Not ideal but I was hungry and late for work lol I will probably maintain a weekly log unless asked for updates.

[SlimmerMe]

I cheated and started last night. Did 200mcg before bed and again this morning. Not sure about the hunger. Was a bit hungry already but pretty much thought about food for the first hour. This morning I had stronger appetite. Noticed. Stomach grinning and bit of extra gas. Had no time for eggs. Grabbed a pop tart and yogurt for breakfast. Not ideal but I was hungry and late for work lol I will probably maintain a weekly log unless asked for updates.

is this what you are after? a stronger appetite? hope so~

[dirtybrd]

I put 5cc of BW in mine. That way my doses are 5iu for 100mgs and is just easier to inject, personally. Or I messed up my last mixture, lol.

[DCannon]

I put 5cc of BW in mine. That way my doses are 5iu for 100mgs and is just easier to inject, personally. Or I messed up my last mixture, lol.

How did you fit 5ml in the vial?

Also, 5ml in to 5mg vial gives you 1mg/ml or 100mcg for every 10 mark on a slin pin not every 5 mark. You're actually doing 50mcg shots.

[dirtybrd]

Dang it! Ive been using 2cc to mix it, then removing it from the tiny vial and putting it in a bigger one for storage in the fridge, adding the other 3cc after its been transfered.

[DCannon]

Dang it! Ive been using 2cc to mix it, then removing it from the tiny vial and putting it in a bigger one for storage in the fridge, adding the other 3cc after its been transfered.

You want to mix with as little water as possible. I use 2.5ml for 5mg but I know guys who only use 0.6ml.

[dirtybrd]

The only reason i use more water is to make controlling the dose easier. but if u say use less I will.

[GunSlingR]

I'm currently using ghrp6 along with cjc1293. Getting good results so far. I didnt notice anything aside from increased hunger for 3 weeks. I am leaning out alot and muscle gained on a test cycle seems to be really solidifying. I have found a difference in quality from one supplier over another. Do do not need more than 100-150mcg for saturation. i noticed no difference from 100-200. Think over 100 its just a waste.
Warchild, what are your goals with the ghrp? Are you running any other gear?

[dirtybrd]

I'm currently using ghrp6 along with cjc1293. Getting good results so far. I didnt notice anything aside from increased hunger for 3 weeks. I am leaning out alot and muscle gained on a test cycle seems to be really solidifying. I have found a difference in quality from one supplier over another. Do do not need more than 100-150mcg for saturation. i noticed no difference from 100-200. Think over 100 its just a waste.
Warchild, what are your goals with the ghrp? Are you running any other gear?

What difference is quaility are you noticing and how?

[DCannon]

I'm currently using ghrp6 along with cjc1293. Getting good results so far. I didnt notice anything aside from increased hunger for 3 weeks. I am leaning out alot and muscle gained on a test cycle seems to be really solidifying. I have found a difference in quality from one supplier over another. Do do not need more than 100-150mcg for saturation. i noticed no difference from 100-200. Think over 100 its just a waste.
Warchild, what are your goals with the ghrp? Are you running any other gear?

Saturation is at 1mcg/kg that's why most people go with 100mcg.

[M302_Imola]

I'm currently using ghrp6 along with cjc1293. Getting good results so far. I didnt notice anything aside from increased hunger for 3 weeks. I am leaning out alot and muscle gained on a test cycle seems to be really solidifying. I have found a difference in quality from one supplier over another. Do do not need more than 100-150mcg for saturation. i noticed no difference from 100-200. Think over 100 its just a waste.
Warchild, what are your goals with the ghrp? Are you running any other gear?

good post...are you injecting both 3 times per day (100mcg each)? I have been injecting twice per day, morning and before bed...I wonder how much more benefit I would get from adding in another injection mostly like pwo?

[GunSlingR]

The quality it seems can be held accountable as just the overall feeling of effect I'm getting. Gone through two more vials from extreme and I'm feeling more energized, sleeping better just overall feeling I have is real good.
I inject at least three times a day. 5am about 130pm and before bed. On work out days I usually pin PWO as well. So I get 4 in on workout days. 100mcg per hit each. I really believe these peptides with accent the cycle I'm starting today. I'll have a log starting on it all tomorrow.

[M302_Imola]

The quality it seems can be held accountable as just the overall feeling of effect I'm getting. Gone through two more vials from extreme and I'm feeling more energized, sleeping better just overall feeling I have is real good.
I inject at least three times a day. 5am about 130pm and before bed. On work out days I usually pin PWO as well. So I get 4 in on workout days. 100mcg per hit each. I really believe these peptides with accent the cycle I'm starting today. I'll have a log starting on it all tomorrow.

thanks...I will be following

[THE-DET-OAK]

Seems after a bit of searching there's mixed opinions which are great to have but im a lot more comfortable with the ppl on these forums than others. Here's my boggle....


5mg vial--how much BW. I've seen 2.5 and 3ml as recommendations. Need to know if you guys think these are accurate. Secondly.....

Shooting 250-300 into the rat daily. Im no math wiz so how many shots per vial would that be?

Even just little help on this would go along way.

are you running a ghrh with your ghrp-6???? if not its kind of a waste. ghrp-6 stimulates GH secretion. our body has a blocker that stops the secretion though, thats how it regulates secretion, GHRH impedes this blocker. you need to do both in order for it to be effective.

[DCannon]

are you running a ghrh with your ghrp-6???? if not its kind of a waste. ghrp-6 stimulates GH secretion. our body has a blocker that stops the secretion though, thats how it regulates secretion, GHRH impedes this blocker. you need to do both in order for it to be effective.

You've got that backwards. GHRP's are fine on their own.

[PK-V]

can it make you go hypo?

I got tunnel vision after 100mcg's for about 10-20 min's after I took my first shot

but I wasn't weak/dizzy/shaky hand etc


also

some people say eating food with it is a bad idea as it will only turn into adipose tissue?

so they say avoid carbs and fat 1/2 hour before and after pinning?

are they right or wrong?

[DCannon]

can it make you go hypo?

I got tunnel vision after 100mcg's for about 10-20 min's after I took my first shot

but I wasn't weak/dizzy/shaky hand etc


also

some people say eating food with it is a bad idea as it will only turn into adipose tissue?

so they say avoid carbs and fat 1/2 hour before and after pinning?

are they right or wrong?

I've never had tunnel vision from GHRP6, did you take anything else with it?

The reason you're not supposed to have fat or carbs near you injection is not because it turns to adipose tissue but because they blunt gh release.

[THE-DET-OAK]

I love empty post's

GH-releasing peptide (GHRP-6; His-D Trp-Ala-Trp-D Phe-Lys-NH2) is a synthetic compound that releases GH in a specific and dose-related manner through mechanisms and a point of action that are mostly unknown but different from those of GHRH. In man, GHRP-6 is more efficacious than GHRH, and a striking synergistic action on GH release is observed when GHRP-6 and GHRH are administered simultaneously.

http://jcem.endojournals.org/cgi/con...tract/80/3/942

it was late when i posted that so i got it backwards, if you read the study you will see GH secretion is almost tripled when the 2 are taken together, rather than GHRP-6 on its own.

But hey, im taking something to maximize results, so why not just take one and do it half-assed.

so yea your right, taking just 1 works, but not that well.

[PK-V]

I've never had tunnel vision from GHRP6, did you take anything else with it?

The reason you're not supposed to have fat or carbs near you injection is not because it turns to adipose tissue but because they blunt gh release.

just took my second shot since making that post and everything was fine

the first time I took the GHRP was a few hours after a workout, it only dawned on me now that it was pprobablyjust low blood sugar levels

interestingly enough I just read an article and it states exactly what you just posted abou the blunting of GH release

Here's the article, it will fit right in with THE-DET-OAK's post

A Brief Summary of Dosing and Administration

Dosing GHRPs

The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin side-effects.

Ipamorelin is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range.

GHRP-2 is a little more efficacious then GHRP-6 at causing GH release but at the saturation dose or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing an increase in GH release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal.
Desensitization

GHRP-6 can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 probably at saturation dose several times a day will not result in desensitization.

Hexarelin has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these GHRPs simply stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed several times a day every day will not cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) all are basically GHRH and have a short half-life in plasma because of quick cleavage between the 2nd & 3rd amino acid. This is no worry naturally because this hormone is secreted from the hypothalamus and travels a short distance to the underlying anterior pituitary and is not really subject to enzymatic cleavage. The release from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

However when injected into the body it must circulate before finding its way to the pituitary and so within 3 minutes it is already being degraded.

That is why GHRH in the above forms must be dosed high to get an effect.

GHRH analogs

All GHRH analogs swap Alanine at the 2nd position for D-Alanine which makes the peptide resistant to quick cleavage at that position. This means analogs will be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or referred to by me as modified GRF(1-29) has other amino acid modifications. They are a glutamine (Gln or Q) at the 8-position, alanine (Ala or A) at the 15-position, and a leucine (Leu or L) at the 27-position.

The alanine at the 8th position enhances bioavailability but the other two amino substitutions are made to enhance the manufacturing process (i.e. create manufacturing stability).

For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide with a half-life probably 30+ minutes.

That is long enough to be completely effective.

The saturation dose is also defined as 100mcg.

Problem w/ Using any GHRH alone

The problem with using a GHRH even the stronger analogs is that they are only highly effective when somatostatin is low (the GH inhibiting hormone). So if you unluckily administer in a trough (or when a GH pulse is not naturally occurring) you will add very little GH release. If however you luckily administer during a rising wave or GH pulse (somatostatin will not be active at this point) you will add to GH release.

Solution is GHRP + GHRH analog

The solution is simple and highly effective. You administer a GHRH analog with a GHRP. The GHRP creates a pulse of GH. It does this through several mechanisms. One mechanism is the reduction of somatostatin release from the hypothalamus, another is a reduction of somatostatin influence at the pituitary, still another is increased release of GHRH from the brain and finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a way of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH is not additive it is synergistic. By that I mean:

If GHRH by itself will cause a GH release valued at 2
and GHRP itself will cause a GH release valued at 5

Together the GH is not 7 (5+2) it turns out to say 16!
A solid protocol

A solid protocol would be to use a GHRP + a GHRH analog pre-bed (to support the nightime pulse) and once or twice throughout the day.

For anti-aging, deep restful restorative sleep, the once at night dosing is all you need. For an adult aged 40+ it is enough to restore GH to youthful levels.

However for bodybuilding or fatloss or injury repair multiple dosings can be effective.

The GHRH analog can be used at 100mcg and as high as you want without problems.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg will probably be fine as well.

Again desensitization is something to keep an eye on particularly with the highest doses of GHRP-2 and all doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together will be effective.
This may be dosed several times a day to be highly effective.

A solid approach is a bit more conservative at 100mcg of GHRP-6 + 100mcg of a GHRH analog dosed either once, twice, three or four times a day.
When dosing multiple times a day at least 3 hours should separate the administrations.

The difference is once a day dosing pre-bed will give a youthful restorative amount of GH while multiple dosing and or higher levels will give higher GH & IGF-1 levels when coupled with diet & exercise will lead to muscle gain & fatloss.

Dose w/o food

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 minutes (no more then 30 but no less then 15 minutes) to eat. AT that point the GH pulse has about hit the peak and you can eat what you want.

[THE-DET-OAK]

nice post bro

[M302_Imola]

PK-V thanks for the post...learned a lot!

[DCannon]

just took my second shot since making that post and everything was fine

the first time I took the GHRP was a few hours after a workout, it only dawned on me now that it was pprobablyjust low blood sugar levels

interestingly enough I just read an article and it states exactly what you just posted abou the blunting of GH release

Here's the article, it will fit right in with THE-DET-OAK's post

A Brief Summary of Dosing and Administration

Dosing GHRPs

The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin side-effects.

Ipamorelin is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range.

GHRP-2 is a little more efficacious then GHRP-6 at causing GH release but at the saturation dose or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing an increase in GH release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal.
Desensitization

GHRP-6 can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 probably at saturation dose several times a day will not result in desensitization.

Hexarelin has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg three times a day will likely lead to some down regulation within 14 days.

If desensitization were to ever occur for any of these GHRPs simply stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed several times a day every day will not cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) all are basically GHRH and have a short half-life in plasma because of quick cleavage between the 2nd & 3rd amino acid. This is no worry naturally because this hormone is secreted from the hypothalamus and travels a short distance to the underlying anterior pituitary and is not really subject to enzymatic cleavage. The release from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

However when injected into the body it must circulate before finding its way to the pituitary and so within 3 minutes it is already being degraded.

That is why GHRH in the above forms must be dosed high to get an effect.

GHRH analogs

All GHRH analogs swap Alanine at the 2nd position for D-Alanine which makes the peptide resistant to quick cleavage at that position. This means analogs will be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or referred to by me as modified GRF(1-29) has other amino acid modifications. They are a glutamine (Gln or Q) at the 8-position, alanine (Ala or A) at the 15-position, and a leucine (Leu or L) at the 27-position.

The alanine at the 8th position enhances bioavailability but the other two amino substitutions are made to enhance the manufacturing process (i.e. create manufacturing stability).

For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide with a half-life probably 30+ minutes.

That is long enough to be completely effective.

The saturation dose is also defined as 100mcg.

Problem w/ Using any GHRH alone

The problem with using a GHRH even the stronger analogs is that they are only highly effective when somatostatin is low (the GH inhibiting hormone). So if you unluckily administer in a trough (or when a GH pulse is not naturally occurring) you will add very little GH release. If however you luckily administer during a rising wave or GH pulse (somatostatin will not be active at this point) you will add to GH release.

Solution is GHRP + GHRH analog

The solution is simple and highly effective. You administer a GHRH analog with a GHRP. The GHRP creates a pulse of GH. It does this through several mechanisms. One mechanism is the reduction of somatostatin release from the hypothalamus, another is a reduction of somatostatin influence at the pituitary, still another is increased release of GHRH from the brain and finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a way of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH is not additive it is synergistic. By that I mean:

If GHRH by itself will cause a GH release valued at 2
and GHRP itself will cause a GH release valued at 5

Together the GH is not 7 (5+2) it turns out to say 16!
A solid protocol

A solid protocol would be to use a GHRP + a GHRH analog pre-bed (to support the nightime pulse) and once or twice throughout the day.

For anti-aging, deep restful restorative sleep, the once at night dosing is all you need. For an adult aged 40+ it is enough to restore GH to youthful levels.

However for bodybuilding or fatloss or injury repair multiple dosings can be effective.

The GHRH analog can be used at 100mcg and as high as you want without problems.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg will probably be fine as well.

Again desensitization is something to keep an eye on particularly with the highest doses of GHRP-2 and all doses of Hexarelin.

So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together will be effective.
This may be dosed several times a day to be highly effective.

A solid approach is a bit more conservative at 100mcg of GHRP-6 + 100mcg of a GHRH analog dosed either once, twice, three or four times a day.
When dosing multiple times a day at least 3 hours should separate the administrations.

The difference is once a day dosing pre-bed will give a youthful restorative amount of GH while multiple dosing and or higher levels will give higher GH & IGF-1 levels when coupled with diet & exercise will lead to muscle gain & fatloss.

Dose w/o food

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 minutes (no more then 30 but no less then 15 minutes) to eat. AT that point the GH pulse has about hit the peak and you can eat what you want.

This is an article by "DatBtrue", who many consider a guru on peptides. He is who I learned everything I now about peptides from.

[blacksmoke]

Do you mix both of these compounds in the same syringe for injects? Or one for each compound?

[M302_Imola]

Every 10 mark on your slin pin (or 0.1ml) is 200mcg. It doesn't take very much water.

This would make every 5 mark equal to 100mcg, correct?

[PK-V]

This is how I done mine

7 X 0.5ML SHOTS OF BAC IN THE GHRP VIAL
3.5ML'S OF BAC IN TOTAL
7 UNITS WILL GIVE YOU 100 MCG'S

[DCannon]

Do you mix both of these compounds in the same syringe for injects? Or one for each compound?

You can mix them if you are injecting right away. You can't store them mixed together.

[DCannon]

This is how I done mine

7 X 0.5ML SHOTS OF BAC IN THE GHRP VIAL
3.5ML'S OF BAC IN TOTAL
7 UNITS WILL GIVE YOU 100 MCG'S

If you add 2.5ml instead of 3.5ml it will make the math easier.

[M302_Imola]

If you add 2.5ml instead of 3.5ml it will make the math easier.

I agree...so by adding 2.5ml the 5 mark on the slin pin is equal to 100mcg, correct?

[DCannon]

I agree...so by adding 2.5ml the 5 mark on the slin pin is equal to 100mcg, correct?

That is correct sir.

[M302_Imola]

^^^thanks...you the man!

[jay_duz]

hey sorry for random bump, but i thinking of getting on cjc 1295 and ghrp-6. will 100mcg of each 3 times a day work well?