Insulin effects on adrenergic system

**fiddlesticks** · 01-11-2019, 03:12 PM

This is a topic I am extremely interested in because there are conflicting experiences from medical literature and real life experience having drastically different outcomes a lot of the time, it would appear insulin potentiates and also dampens certain adrenergic functions. Personally I notice a potentiation of dopaminergic and beta adrenergic activity when using decent insulin doses. When I inject albuterol with insulin for example the effects are much more potent than albuterol alone. If the idea that insulin increases beta adrenergic activity is accurate it just shows how useful it could be for cutting fat.

**Quester** · 01-14-2019, 06:59 PM

Could you please post links to the medical literature? It is an interesting concept.

**fiddlesticks** · 01-14-2019, 10:29 PM

Originally Posted by Quester

Could you please post links to the medical literature? It is an interesting concept.

https://scholar.google.com/scholar?h...3DwlH0B40Oy-cJ

If we are to believe this study, the results of gh and insulin seriously are the fountain of youth. Unbelievable really. This study also doesn't mention t4>t3 conversion, vasorelaxation effects and general healing ability of the two hormones either. Insulin is far more than just the most potent anabolic , perhaps its the most potent neurogenic as well.

I always have thought lower insulin activity was one of the main hallmarks of aging and this pretty much shows it clear as day.

**fiddlesticks** · 02-03-2019, 12:42 PM

I can say with 100 percent certainty I always feel like shit after discontinuing insulin , mentally I just have no energy at all.

**Obs** · 02-03-2019, 07:15 PM

I get sleepy as hell and lethargic during uptake but feel powerful and great afterward

**Quester** · 02-03-2019, 08:29 PM

Originally Posted by fiddlesticks

https://scholar.google.com/scholar?h...3DwlH0B40Oy-cJ

If we are to believe this study, the results of gh and insulin seriously are the fountain of youth. Unbelievable really. This study also doesn't mention t4>t3 conversion, vasorelaxation effects and general healing ability of the two hormones either. Insulin is far more than just the most potent anabolic , perhaps its the most potent neurogenic as well.

I always have thought lower insulin activity was one of the main hallmarks of aging and this pretty much shows it clear as day.

This is a link to google scholar, which of the list is pertinent?

**fiddlesticks** · 02-03-2019, 09:01 PM

Oh for me it 'links to

Adrenergic, dopaminergic and serotonergic gene expression in low dose, long time insulin and somatotropin treatment to ageing rats: rejuvenation of brain function

**Proximal** · 02-10-2019, 01:28 PM

Nice article. Always a bit sceptical though when looking at the age of articles and a lack of newer research that follows up and confirms the findings. But still, nice read.

**fiddlesticks** · 02-10-2019, 03:49 PM

Originally Posted by Proximal

Nice article. Always a bit sceptical though when looking at the age of articles and a lack of newer research that follows up and confirms the findings. But still, nice read.

I am surprised more people don't discuss how you usually will feel going off insulin after cycling it.. It makes me feel worse than having low test. Completely debilitating. When you think about it going from insulin levels 50x+ higher than normal to normal is far more dramatic than test levels 2-6 times higher.

**Proximal** · 02-10-2019, 04:12 PM

There is something that you might be overlooking. The possibility that the receptors for insulin on the body cells in seeing this excess insulin, start to shut down and refuse more & more of it, as in diabetes type 2. But again, nice article.

**fiddlesticks** · 02-11-2019, 01:11 PM

Originally Posted by Proximal

There is something that you might be overlooking. The possibility that the receptors for insulin on the body cells in seeing this excess insulin, start to shut down and refuse more & more of it, as in diabetes type 2. But again, nice article.

What I'm trying to say is the body will not make even remotely close (ive read studies of BW adjusted doses raising insulin levels around 80x) levels of insulin ever. Even if the receptors upregulate, sensitivity increases etc it's still a massive deficit of insulin action. I'm honestly surprised the whole coming off insulin thing isn't talked about more, it's very brutal for your muscle gains and your energy levels. If insulin has ANY minor effect on neurochemical stuff it will be totally messed up post-use.