Raloxifene: The Ultimate Gyno Treatment??

[RUI-Products]

Raloxifene is a SERM , Selective Estrogen Receptor Modulator, much like tamoxifen and toremifene as well as clomiphene.. Serms, just as their name indicates, bind selectively to estrogen receptors in different tissues eliciting some interesting responses.

In order to understand how to treat gyno we first need to understand exactly what it is. Gynecomastia is abnormal development of breast tissue in males. The primary cause of this is high levels of estrogen. This excess estrogen begins eliciting its effects on the estrogen receptors in the breast tissue, causing tissue growth and development.

There have been many approaches to the prevention and treatment of gyno. More recently the use of an aromatase inhibitor has been advocated for such a purpose. An ai lowers circulating estrogen levels – therefore less estrogen – less binding to breast tissue. Absence of estrogen at the receptor site in breast tissue causes tissue cell death. That is one approach – however alone it may not be most effective.

Tamoxifen was/is another traditional approach to the treatment of gyno. Tamox acts as an estrogen, binding more strongly to selective estrogen receptors, like the receptors in breast tissue. This prevents the estrogen from exerting any effects on the receptor and the tissue effected. Pretty good treatment and it does work. There is plenty of data to support its effectiveness.

So we already said raloxifene is in the same family of compounds as tamoxifen. So what makes it any better for gyno treatment. Well raloxifene, it turns out, has about 10x the binding affinity for the estrogen receptor in breast tissue than tamoxifen does. It binds much more strongly to the receptor site, virtually eliminating the possibility of any estrogen reaching a receptor and exerting the undesired effect. There are head to head studies proving raloxifene is more effective at treating and relieving gyno than tamoxifen is.

Again there are different approaches to the treatment of gyno, but the approach of using a serm is definitely the most effective. It may be prudent to combine this with the use of an ai to lower estrogen as well, lessening the likelihood of the occurrence. However, for treatment a serm, specifically raloxifene , cannot be beat. Remember if no estrogen reaches the recptor in the brest tissue – the tissue dies. There is no way using an ai to eliminate all estrogen, however with a potent serm like raloxifene , you can prevent any from exerting its effects . If gyno is an issue in your research, it would be very wise to look into this often overlooked but valuable serm.

Get it here >> Raloxifene 120


Refs:
*Vogel, Victor; Joseph Constantino, Lawrence Wickerman et al. (2006-06-21). "Effects of Tamoxifen vs. Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes". The Journal of the American Medical Association 295 (23): 2727–2741. doi:10.1001/jama.295.23.joc60074. PMID 16754727
*Biochem Pharmacol. 2001 Oct 1;62(7):953-61. Transcriptional activities of estrogen receptor alpha and beta in yeast properties of raloxifene. Jisa E, Dornstauder E, Ogawa S, Inoue S, Muramatsu M, Jungbauer A. Source Institute of Applied Microbiology, University of Agricultural Sciences, Vienna, Austria.
*J Pediatr. 2004 Jul;145(1):71-6. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.SourceDepartment of Pediatrics, University of Ottawa, Ontario, Canada. [email protected]
*Molecular Characterization of the Microsomal Tamoxifen Binding Site*Blandine Kedjouar, Philippe de Médina, Mustapha Oulad-Abdelghani‡,Bruno Payré, Sandrine Silvente-Poirot, Gilles Favre, Jean-Charles Faye and Marc Poirot§ E-mail: [email protected].
*http://humupd.oxfordjournals.org/con...3/212.full.pdf – Pharmacological Review of Selective Estrogen Recptor Modulators


Raloxifene 120

[jimmyinkedup]

I just recently posted about this in a gyno thread. Raloxi is the best gyno treatment avail. That + ai = best chances of success imo.
Nice write up arr.
If you have gyno - this is the compound for you.

[Swifto]

Yes, Rolax is top of the pile for gynecomastia .

Tore and Tamoxifen are actually the same, but Tore should be chosen due to being generally a lot less toxic than Tamoxifen.

[RUI-Products]

Thanks for the support guys. :-)

[RUI-Products]

Get it here >> Raloxifene 120

[RUI-Products]

Raloxifene is a SERM , Selective Estrogen Receptor Modulator, much like tamoxifen and toremifene as well as clomiphene.. Serms, just as their name indicates, bind selectively to estrogen receptors in different tissues eliciting some interesting responses.

In order to understand how to treat gyno we first need to understand exactly what it is. Gynecomastia is abnormal development of breast tissue in males. The primary cause of this is high levels of estrogen. This excess estrogen begins eliciting its effects on the estrogen receptors in the breast tissue, causing tissue growth and development.

There have been many approaches to the prevention and treatment of gyno. More recently the use of an aromatase inhibitor has been advocated for such a purpose. An ai lowers circulating estrogen levels – therefore less estrogen – less binding to breast tissue. Absence of estrogen at the receptor site in breast tissue causes tissue cell death. That is one approach – however alone it may not be most effective.

Tamoxifen was/is another traditional approach to the treatment of gyno. Tamox acts as an estrogen, binding more strongly to selective estrogen receptors, like the receptors in breast tissue. This prevents the estrogen from exerting any effects on the receptor and the tissue effected. Pretty good treatment and it does work. There is plenty of data to support its effectiveness.

So we already said raloxifene is in the same family of compounds as tamoxifen. So what makes it any better for gyno treatment. Well raloxifene, it turns out, has about 10x the binding affinity for the estrogen receptor in breast tissue than tamoxifen does. It binds much more strongly to the receptor site, virtually eliminating the possibility of any estrogen reaching a receptor and exerting the undesired effect. There are head to head studies proving raloxifene is more effective at treating and relieving gyno than tamoxifen is.

Again there are different approaches to the treatment of gyno, but the approach of using a serm is definitely the most effective. It may be prudent to combine this with the use of an ai to lower estrogen as well, lessening the likelihood of the occurrence. However, for treatment a serm, specifically raloxifene , cannot be beat. Remember if no estrogen reaches the recptor in the brest tissue – the tissue dies. There is no way using an ai to eliminate all estrogen, however with a potent serm like raloxifene , you can prevent any from exerting its effects . If gyno is an issue in your research, it would be very wise to look into this often overlooked but valuable serm.

Get it here >> Raloxifene 120


Refs:
*Vogel, Victor; Joseph Constantino, Lawrence Wickerman et al. (2006-06-21). "Effects of Tamoxifen vs. Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes". The Journal of the American Medical Association 295 (23): 2727–2741. doi:10.1001/jama.295.23.joc60074. PMID 16754727
*Biochem Pharmacol. 2001 Oct 1;62(7):953-61. Transcriptional activities of estrogen receptor alpha and beta in yeast properties of raloxifene. Jisa E, Dornstauder E, Ogawa S, Inoue S, Muramatsu M, Jungbauer A. Source Institute of Applied Microbiology, University of Agricultural Sciences, Vienna, Austria.
*J Pediatr. 2004 Jul;145(1):71-6. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.SourceDepartment of Pediatrics, University of Ottawa, Ontario, Canada. [email protected]
*Molecular Characterization of the Microsomal Tamoxifen Binding Site*Blandine Kedjouar, Philippe de Médina, Mustapha Oulad-Abdelghani‡,Bruno Payré, Sandrine Silvente-Poirot, Gilles Favre, Jean-Charles Faye and Marc Poirot§ E-mail: [email protected].
*http://humupd.oxfordjournals.org/con...3/212.full.pdf – Pharmacological Review of Selective Estrogen Recptor Modulators


Raloxifene 120

Read this ^^^

Get it here >> Raloxifene 120

Then research it ^^^

[Bjwr]

What would the dosage be if u have some rebound gyno and u want it gone?
Hard lump under left nipple, little bit puffy. Sub 12%BF so it's not a fatty deposit

[jimmyinkedup]

What would the dosage be if u have some rebound gyno and u want it gone?
Hard lump under left nipple, little bit puffy. Sub 12%BF so it's not a fatty deposit

60-80mg/day.

[RUI-Products]

Great product....

[RUI-Products]

Keep on researching and learning.

[RUI-Products]

Quality product.

[RUI-Products]

Follow us on twitter @arrchems to get the latest research article and special promos!

[horse_boy]

any chance of getting this in australia?

[horse_boy]

Raloxifene is a SERM , Selective Estrogen Receptor Modulator, much like tamoxifen and toremifene as well as clomiphene.. Serms, just as their name indicates, bind selectively to estrogen receptors in different tissues eliciting some interesting responses.

In order to understand how to treat gyno we first need to understand exactly what it is. Gynecomastia is abnormal development of breast tissue in males. The primary cause of this is high levels of estrogen. This excess estrogen begins eliciting its effects on the estrogen receptors in the breast tissue, causing tissue growth and development.

There have been many approaches to the prevention and treatment of gyno. More recently the use of an aromatase inhibitor has been advocated for such a purpose. An ai lowers circulating estrogen levels – therefore less estrogen – less binding to breast tissue. Absence of estrogen at the receptor site in breast tissue causes tissue cell death. That is one approach – however alone it may not be most effective.

Tamoxifen was/is another traditional approach to the treatment of gyno. Tamox acts as an estrogen, binding more strongly to selective estrogen receptors, like the receptors in breast tissue. This prevents the estrogen from exerting any effects on the receptor and the tissue effected. Pretty good treatment and it does work. There is plenty of data to support its effectiveness.

So we already said raloxifene is in the same family of compounds as tamoxifen. So what makes it any better for gyno treatment. Well raloxifene, it turns out, has about 10x the binding affinity for the estrogen receptor in breast tissue than tamoxifen does. It binds much more strongly to the receptor site, virtually eliminating the possibility of any estrogen reaching a receptor and exerting the undesired effect. There are head to head studies proving raloxifene is more effective at treating and relieving gyno than tamoxifen is.

Again there are different approaches to the treatment of gyno, but the approach of using a serm is definitely the most effective. It may be prudent to combine this with the use of an ai to lower estrogen as well, lessening the likelihood of the occurrence. However, for treatment a serm, specifically raloxifene , cannot be beat. Remember if no estrogen reaches the recptor in the brest tissue – the tissue dies. There is no way using an ai to eliminate all estrogen, however with a potent serm like raloxifene , you can prevent any from exerting its effects . If gyno is an issue in your research, it would be very wise to look into this often overlooked but valuable serm.

Get it here >> Raloxifene 120


Refs:
*Vogel, Victor; Joseph Constantino, Lawrence Wickerman et al. (2006-06-21). "Effects of Tamoxifen vs. Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes". The Journal of the American Medical Association 295 (23): 2727–2741. doi:10.1001/jama.295.23.joc60074. PMID 16754727
*Biochem Pharmacol. 2001 Oct 1;62(7):953-61. Transcriptional activities of estrogen receptor alpha and beta in yeast properties of raloxifene. Jisa E, Dornstauder E, Ogawa S, Inoue S, Muramatsu M, Jungbauer A. Source Institute of Applied Microbiology, University of Agricultural Sciences, Vienna, Austria.
*J Pediatr. 2004 Jul;145(1):71-6. Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia.Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.SourceDepartment of Pediatrics, University of Ottawa, Ontario, Canada. [email protected]
*Molecular Characterization of the Microsomal Tamoxifen Binding Site*Blandine Kedjouar, Philippe de Médina, Mustapha Oulad-Abdelghani‡,Bruno Payré, Sandrine Silvente-Poirot, Gilles Favre, Jean-Charles Faye and Marc Poirot§ E-mail: [email protected].
*http://humupd.oxfordjournals.org/con...3/212.full.pdf – Pharmacological Review of Selective Estrogen Recptor Modulators


Raloxifene 120

hello, great info, thankyou. will Raloxifene cure or better my pea size gyno lumps, they are 6 months old?

[jimmyinkedup]

hello, great info, thankyou. will Raloxifene cure or better my pea size gyno lumps, they are 6 months old?

Its your best bet in my opinion. I just replied in your other thread re: this topic.

[Combatant]

So taking this product while on cycle mixed with an AI is alright or better to take as an AI without Arimidex or Aromasin .

[Juced_porkchop]

So taking this product while on cycle mixed with an AI is alright or better to take as an AI without Arimidex or Aromasin.

If on cycle you should always stay on AI to control estrogen levels. if gyno pops up and you are upping AI dose to correct the estrogen/gyno issues then add a low dose SERM to cycle WITH the AI and after a few weeks if being on higher AI dose, drop SERM and see how you do, I rec going for blood work just before dropping SERM though if possible, IMO.
if OFF cycle then just use the SERM for trying to rid gyno and your estrogen levels are good.