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Thread: Pct science question

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    641
    641 is offline Junior Member
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    Question Pct science question

    New to the world of anabolics and trying to learn,

    During pct our estrogen receptors are blocked (?) So how does estrogen get to do its job if the receptors are blocked?

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    numbere is offline RETIRED- Knowledgeable member
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    There are many factors but the short answer to your question is the active life of a compound. The active life of a compound is the period of time in which an amount of a compound in the body is enough that it will produce the desired effect. Clomid and nolva have an active life of about 5-7 days. Compounds in the body (e.g. nolva, estrogen) are actively competing for binding sites. When one compound is no longer active another takes it's place.
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    WhiteBoy18's Avatar
    WhiteBoy18 is offline Junior Member
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    Quote Originally Posted by 641 View Post
    New to the world of anabolics and trying to learn,

    During pct our estrogen receptors are blocked (?) So how does estrogen get to do its job if the receptors are blocked?
    You have to experiment with blood work and find your sweet spot. Nova will block it from attaching to the receptor, but will not eliminate it. So when you are off of it, the sides will start to show from high est. This is why people use Arimidex or Aromasin . Arimidex is a POWERFUL AI and can hinder your gains drastically if you do not find the right dosage. Arimidex stops the production of E almost completely (which is not a good thing).

    So to sum it up, estrogen wont do its job if its blocked completely. BW is needed to perfect this.

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    stronger1986 is offline New Member
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    Estrogen doesn't take effect fully in the presence of SARMs

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    PrettyPlease? is offline Banned
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    Quote Originally Posted by 641 View Post
    New to the world of anabolics and trying to learn,

    During pct our estrogen receptors are blocked (?) So how does estrogen get to do its job if the receptors are blocked?
    Which job in specific are you referring to? Keep in mind we use SERMs to competitively bind to the estrogen receptor. The "SER" in SERM stands for "Selective Estrogen Receptor" meaning it is only binding to certain estrogen receptors and blocking estrogen, in other receptor sites it is actually acting as an agonist.

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