DHEA: What you should know.

[steroid.com 1]

Dehydroepiandrosterone: DHEA
As presented by Dr. Neal Rouzier, M.D.

Here's a great reason to add DHEA to your protcol.

DHEA is a hormone secreted primarily by the adrenal glands. It results in a shift of a catabolic state to an anabolic or protein building state.

 It reduces cardiovascular risks by increasing lipolyses (decrease visceral fat).
 It stimulates the immune system, restores sexual vitality, improves moods, decreases cholesterol and body fat.
 It improves memory, increases energy, and has anti-cancer properties by enhancing the immune system.
 It is an endocrine precursor to other hormones, prevents immuno-senescence, loss of sleep, osteoporosis, atherosclerosis.
 DHEA reduces insulin requirement
 Adrenal hormone anabolic vs. catabolic metabolism
 Restores immunity
 Prevents osteoporosis, increases bone density
 Prevents cancer in lab animals
 Prevents diabetes & heart disease
 Decreases visceral fat
 Improves mood & well-being
 Improves energy & memory
 Slows aging process in lab animals
 Prevents lipid peroxidation =
antioxidant
 Endocrine precursor to T.P.E.
 7-keto DHEA is not a precursor to other HRT = avoid
 Neurotransmitter (recently discovered)
 Presently pending FDA approval for Lupus (Prasterone)

Clinically substantiated uses of DHEA include replacement for:
 Low DHEA levels
 Chronic disease
 Adrenal exhaustion or corticosteroid therapy
 SLE
 Improving bone density
 Improving depression & mood disorders
 Enhancing immune response by activating T-cells
 Improving well-being
 Decreasing cardiovascular risk
 Improving erectile dysfunction
 Anyone over 40
 DHEA has never been shown to reverse the aging process
 Nevertheless DHEA is important for preventive medicine
 DHEA inhibits synthesis of thromboxane A2, reduces plasminogen activator inhibitor, and tissue plasminogen activator
– all decreasing platelet aggregation and ischemia.

Administraiton:
Men<200lb: 50mg AM
Men>200lb: 75-100mg AM

Women <50yo: 10-15mg AM
Women >50yo: 25mg AM

IMPORTANT:
DHEA Serum Levels
 MEN
 Range 100-600
 Optimal 500-600
WOMEN
 Range 50-300
 Optimal 200-250

Higher levels in women predispose them to side effects – therefore stay low
 Monitor monthly until optimal
 Assure correct dose and compliance
 Measure DHEA-S and not DHEA

 Side effects: acne, hirsutism
 Tx: Lower dose or take QOD Spironolactone 100 mg/day
 Contraindicated in sex hormone responsive tumors – breast, ovarian, uterine, prostate
 Conversion to T.P.E.?
 DHEA raises testosterone levels in women slightly, yet not in men
 DHEA raises estradiol slightly in men

Indications:
 Over age 40 for health protection
 Preventive medicine and well-being
 Symptoms of aging, mood & depression
 ‘Cause the medical literature suggests it if we want to live longer, happier, healthier

DHEA – S04
 MEN Blood levels
 Optimal : 500-600 ug/ml
 Side effects rare in men
WOMEN
 Optimal : 200-250 ug/ml
 Dose based on side effects
 Side effects very common in women

DHEA Dose
 MEN
 Capsule – SR micronized
 50 mg Q am
 >200 lbs – 75 - 100 mg Q am

WOMEN
 Capsule – SR micronized
 10 mg Q am if over 40
 15 mg Q am if over 50
 25 mg Q am if over 60
 If under age 40, do not prescribe due to sensitivity causing side effects.

[Brazensol]

Great post! Do you think micronized is better than sublingual? Do you use it and do you have a reliable manufacturer if you do?

[xtitan1]

GD, thank you for this great information.

Would you recommend that a male within normal reference range limits but low compared to the optimal range of 500-600, for example 350, should add DHEA to their protocol?

[Sheven]

 7-keto DHEA is not a precursor to other HRT = avoid

could you explain to me what does that mean ? 7-keto DHEA is the precursor of DHEA

[jimmyinkedup]

Great info as usual Gdev !!

[steroid.com 1]

Great post! Do you think micronized is better than sublingual? Do you use it and do you have a reliable manufacturer if you do?

Yes, I use both a 15mg of transdermal and 50mg of micronized DHEA. If you noticed where Dr. Rouizer recommends DHEA-S to be at the top of the reference range...this is huge. My last BW had be just below mid range and my Doc wants me at the top so we've added in 50mg of micronized DHEA on top of the transdermal.

[steroid.com 1]

GD, thank you for this great information.

Would you recommend that a male within normal reference range limits but low compared to the optimal range of 500-600, for example 350, should add DHEA to their protocol?

My Doc, an excellent A4M TRT Physician, wants his men as close to 600 as possible now!!!

[steroid.com 1]

could you explain to me what does that mean ? 7-keto DHEA is the precursor of DHEA

You can Google this and get a ton of information.

Simply put, 7-Keto DHEA is not DHEA and can't be substituted for it if one is looking for the benefits of DHEA supplementation; why the Doc's comment.

[steroid.com 1]

Great info as usual Gdev !!

Thanks bro, means a lot coming from you.

BTW, half sleeve on right is done and now working on the left half sleeve...many more sessions to go!

[Sheven]

You can Google this and get a ton of information.

Simply put, 7-Keto DHEA is not DHEA and can't be substituted for it if one is looking for the benefits of DHEA supplementation; why the Doc's comment.

i can understand that 7-Keta DHEA (CAS 566-19-8) is different to Dehydroepiandrostenorone (CAS 53-43-0). Yes is different but what does that coment mean, that "7-keto DHEA is not a precursor to other HRT = avoid"

7-keto dhea is the step before synthesis DHEA, 7-keto DHEA is the precursor of DHEA, so what's the remark wanting to say ?

[Times Roman]

and this is in addition to trt, right?

[startingnew]

I didn't really see the need to take DHEA....until now.I guess that's why my TRT Dr had such a hard on that I take it.He wanted my levels to be at 600,and this was on top of my weekly test injections.I've been taking it,when I remember to do so but will make sure to take it daily now.Also said to take 4-5000mgs of fish oil a day.

[xtitan1]

I was just looking at LabCorp's reference range and the top end is only 492 ug/dL for DHEA-S?

[Brazensol]

Is the product your using come from the pharmacy or do you buy otc? If otc can you say what it is or, if not, pm me?

[stpete]

Good read. I take it everyday.

[steroid.com 1]

i can understand that 7-Keta DHEA (CAS 566-19-8) is different to Dehydroepiandrostenorone (CAS 53-43-0). Yes is different but what does that coment mean, that "7-keto DHEA is not a precursor to other HRT = avoid"

7-keto dhea is the step before synthesis DHEA, 7-keto DHEA is the precursor of DHEA, so what's the remark wanting to say ?

My understanding is that 7-keto DHEA is NOT naturally found in the human body and because of the structure of 7-keto DHEA, the natural enzymes in the human body cannot convert it to estrogen or testosterone .

[steroid.com 1]

and this is in addition to trt, right?

Yes.

Plus, it's just good to back-fill the pathways when a man is on a TRT protocol.

[steroid.com 1]

Is the product your using come from the pharmacy or do you buy otc? If otc can you say what it is or, if not, pm me?

I like Life Extension Foundation's DHEA. www.lef.org

All of their DHEA supplements are micronized for higher uptake rates.

[HRTstudent]

Does everyone take it just once in the AM?

How is the body's natural DHEA released throughout a 24 hour day?

I'm taking pregnenolone just now, but my doctor who focuses on wellness said he wanted my DHEA just a little higher. Its not that low, unlike my testosterone which was low.

[steroid.com 1]

As noted, Dr. Rouzier like to see men at the top of the reference range = 500-600 ug/ml.

Seems to be the consensus amoung TRT Physicians who are in the know.

[Allaaro]

Wish Canada wasn't retarded with their DHEA laws....stuff is insane priced at pharmacy for TRT.

I've heard different things on twice per day or once. Once it will peak then go down by the evening, so some say that is better and gives more energy during day. Others say twice per day to keep levels constant. I got bloods on twice, trying once this time see what changes there are.

Upper range is best, especially since being on TRT for a long time will lower DHEA levels in the body, so eventually most should be supplementing it.

[makingwaves]

I read that dhea when taken before a workout spares T. This means you have T for recovery from workout. I can't find this article so I am doubting my memory. I did not see this in the dhea benefits listed here.

The backfilling idea comes from Crisler et al.

Lef says 50mg daily for men. What is normal range in non TRT men?

[MickeyKnox]

excellent post GD! thank you

[SEOINAGE]

i know you mentioned taking preg with dhea, do you have a pregnenolone thread? I was looking for preg and dhea is a lot easier to find.

[Brohim]

Life Extension website has pregnenolone.

[steroid.com 1]

i know you mentioned taking preg with dhea, do you have a pregnenolone thread? I was looking for preg and dhea is a lot easier to find.

Top sticky on the forum: http://forums.steroid.com/showthread...ou-should-know.

[steroid.com 1]

I read that dhea when taken before a workout spares T. This means you have T for recovery from workout. I can't find this article so I am doubting my memory. I did not see this in the dhea benefits listed here.

The backfilling idea comes from Crisler et al.

Lef says 50mg daily for men. What is normal range in non TRT men?

The same dosage for non TRT men.

[gixxerboy1]

You can Google this and get a ton of information.

Simply put, 7-Keto DHEA is not DHEA and can't be substituted for it if one is looking for the benefits of DHEA supplementation; why the Doc's comment.

My doctor recommended the 7-keto. My dhea levels where almost non existent. I just started 100mg ed

[jimmyinkedup]

7 keto is a dhea metabolite. dhea converts to it in the body.
It doesnt increase e like dhea can. Some say its better. I personally think its probably only good for cortosol control / mangement.
Gix your Dr may have recommended it because of its effects on immune system function.

Oh also if u are using a dhea cream it increases the conversion to 7 keto dhea because if i recall correctly that conversion takes place believe it or not in the skin (and kidney i believe).

[gixxerboy1]

thanks, jimmy. That makes sense since all my autoimmune issues