
Originally Posted by
Merc.
Man I miss the old days with these good debates .( which we can all learn from )..
Anyways keep in mind that about 50% of published articles on Pubmed are wrong ( I work in a lab and this number comes from some of the top Scientist we have working there ).. I will start a thread that has tons of info on determing if a study is legit or not..
So I am sure we could go back and forth on studies all day .. That said check out this one ..
Testosterone suppression of the HPT axis.MacIndoe JH, Perry PJ, Yates WR, Holman TL, Ellingrod VL, Scott SD.
Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, USA.
BACKGROUND: Although studies have demonstrated the suppression of normal gonadal function in the experimental setting, the specific mechanisms by which androgenic-anabolic steroids impact male gonadal function remain ill defined. Following 2 consecutive weekly injections of an identically appearing testosterone cypionate (TC) placebo, subjects were randomized to a TC dose of 100 mg/wk, 250 mg/wk, or 500 mg/wk. Following the last weekly injection of active agent the subjects received 12 consecutive weeks of TC placebo injections. RESULTS: Spermatogenesis was impaired by each of the doses of TC employed in this study, but the observed decreases in, sperm count were neither strictly dose dependent nor consistent between individuals treated with the same dose. Basal leuteinizing hormone (LH) and follicle stimulating hormone (FSH) became undetectable 2 weeks after the start of 250 and 500 mg/wk TC injections and were lost within 5 to 6 weeks of starting 100 mg doses. Pituitary gonadotropin responses to leutinizing hormone releasing hormone (LHRH) disappeared more slowly with FSH responses being lost 1 to 3 weeks after the loss of basal FSH activity. Leuteinizing hormone responses to LHRH appeared to be suppressed last, disappearing 4 to 6 weeks after FSH responses to LHRH. CONCLUSIONS: Exogenous testosterone-mediated inhibitory influences on the hypothalamic-pituitary-testicular axis were reversed following the cessation of drug treatment.
PMID: 9394096 [PubMed - indexed for MEDLINE]..........
I didnt highlight any part of the study because I wanted you to read the whole thing ..
So this study states that one hundred mgs of test per week takes about 5-6 weeks to shut down HPTA... and 250-500mgs shuts you down by week two ..
Great Discussion Swifto ...
Merc.