*Creatine blocks Myostatin*

[Mr.Rose]

Actually, its not from neither ATP or water in the muscle cells, but due to the fact on induction of myogenic cell differentiation

Here is a snippet of an article i wrote in my first year at Uni,

3.3 Physiologic effects of creatine on muscle growth

Muscle growth can be directly related to muscle hypertrophy. Increases in muscle size related to the extended ingestion of creatine have been examined in a number of other studies. These findings were examined by Willoughby and Rosene (2001) who described as follows:

"...it was observed that creatine supplementation resulted in significantly greater increases in type I and II myosin heavy-chain (MHC) mRNA abundance and protein content after 12 wk of resistance training, suggesting that an increase in MHC synthesis may account in part for the greater increases in muscle size with creatine supplementation.”

Further research was then undertaken to observe the effect of creatine on various biological systems within the body and its effects on the expression of various genes related to muscle growth. MRF4 is a protein involved in inducing myogenic cell differentiation and is expressed in developing muscle as it is directly related to muscle growth.

Hespel et al. (2001) showed that an increase in muscle hypertrophy due to the supplementation of creatine is directly related to the protein expression of MRF4. A further study conducted by Willoughby and Rosene (2003) reported that creatine supplementation increased the MRNA expression and consequently the content of MRF4. Collectively, these studies could explain the increases in muscle size and strength that results in the supplementation of creatine compounds.

Now lets discus, .

[MuscleScience]

Actually, its not from neither ATP or water in the muscle cells, but due to the fact on induction of myogenic cell differentiation

Here is a snippet of an article i wrote in my first year at Uni,

3.3 Physiologic effects of creatine on muscle growth

Muscle growth can be directly related to muscle hypertrophy. Increases in muscle size related to the extended ingestion of creatine have been examined in a number of other studies. These findings were examined by Willoughby and Rosene (2001) who described as follows:

"...it was observed that creatine supplementation resulted in significantly greater increases in type I and II myosin heavy-chain (MHC) mRNA abundance and protein content after 12 wk of resistance training, suggesting that an increase in MHC synthesis may account in part for the greater increases in muscle size with creatine supplementation.”

Further research was then undertaken to observe the effect of creatine on various biological systems within the body and its effects on the expression of various genes related to muscle growth. MRF4 is a protein involved in inducing myogenic cell differentiation and is expressed in developing muscle as it is directly related to muscle growth.

Hespel et al. (2001) showed that an increase in muscle hypertrophy due to the supplementation of creatine is directly related to the protein expression of MRF4. A further study conducted by Willoughby and Rosene (2003) reported that creatine supplementation increased the MRNA expression and consequently the content of MRF4. Collectively, these studies could explain the increases in muscle size and strength that results in the supplementation of creatine compounds.

Now lets discus, .

How can you further differentiate a already terminally differentiated cell such as in the case of a muscle cell.?

[IM708]

How can you further differentiate a already terminally differentiated cell such as in the case of a muscle cell.?

lol...

[dec11]

Actually, its not from neither ATP or water in the muscle cells, but due to the fact on induction of myogenic cell differentiation

Here is a snippet of an article i wrote in my first year at Uni,

3.3 Physiologic effects of creatine on muscle growth

Muscle growth can be directly related to muscle hypertrophy. Increases in muscle size related to the extended ingestion of creatine have been examined in a number of other studies. These findings were examined by Willoughby and Rosene (2001) who described as follows:

"...it was observed that creatine supplementation resulted in significantly greater increases in type I and II myosin heavy-chain (MHC) mRNA abundance and protein content after 12 wk of resistance training, suggesting that an increase in MHC synthesis may account in part for the greater increases in muscle size with creatine supplementation.”

Further research was then undertaken to observe the effect of creatine on various biological systems within the body and its effects on the expression of various genes related to muscle growth. MRF4 is a protein involved in inducing myogenic cell differentiation and is expressed in developing muscle as it is directly related to muscle growth.

Hespel et al. (2001) showed that an increase in muscle hypertrophy due to the supplementation of creatine is directly related to the protein expression of MRF4. A further study conducted by Willoughby and Rosene (2003) reported that creatine supplementation increased the MRNA expression and consequently the content of MRF4. Collectively, these studies could explain the increases in muscle size and strength that results in the supplementation of creatine compounds.

Now lets discus, .

bollocks, of course it is. i'd be thinkin a sports degree would cover the same in Aus as in ireland

[Mr.Rose]

Actually, it does...creatine supplementation increases PCr donates phosphate to ADP to create ATP.

Source: Nutrition in sport by Ronald J. Maughen, page 374 2nd paragraph down

No, Im not saying that creatine does not increase PCr and hence donation or phosphate ions to ADP to form ATP. That i know happens. What i did say was that is not the reason for the muscle growth.

bollocks, of course it is. i'd be thinkin a sports degree would cover the same in Aus as in ireland

I dont do a sports degree, I am a Aerospace Mechatronics Engineer, biology is just a hobby, just like chemistry and quantum mechanics. That paper was a first, year first semester thing, where we had to pick a subject that we were not familiar with and write a speech.

How can you further differentiate a already terminally differentiated cell such as in the case of a muscle cell.?

MuscleScience, This is a question: I thought that myogenic cells were like "blank cells" and then they differentiate into the different fiber types. Well that is what the study by Willoughby and Rosene indicated and due to the "significantly greater increases in type I and II myosin heavy-chain (MHC) mRNA abundance and protein content ", that the increased expression of MRF4 "induced myogenic cell differentiation and is expressed in developing muscle as it is directly related to muscle growth.".

I would like to know if that is right or wrong? Phate? MuscleScience? Want to explain?

[IM708]

No, Im not saying that creatine does not increase PCr and hence donation or phosphate ions to ADP to form ATP. That i know happens. What i did say was that is not the reason for the muscle growth.

More ATP = you can lift longer = more force can be put on muscles over a longer period of time = causing greater hypertrophy.

[IM708]

I thought that myogenic cells were like "blank cells" and then they differentiate into the different fiber types.

Ugh, you can't simply switch between slow (I) and fast (II) fibers. There are physical differences between the two types of skeletal muscle fiber, concentration of mitochondria, density of fibers per unit, size of motor neurons surrounding the tissue, capillary concentration, sheer size of the fiber units, enzyme content/concentration

[MuscleScience]

No, Im not saying that creatine does not increase PCr and hence donation or phosphate ions to ADP to form ATP. That i know happens. What i did say was that is not the reason for the muscle growth.



I dont do a sports degree, I am a Aerospace Mechatronics Engineer, biology is just a hobby, just like chemistry and quantum mechanics. That paper was a first, year first semester thing, where we had to pick a subject that we were not familiar with and write a speech.



MuscleScience, This is a question: I thought that myogenic cells were like "blank cells" and then they differentiate into the different fiber types. Well that is what the study by Willoughby and Rosene indicated and due to the "significantly greater increases in type I and II myosin heavy-chain (MHC) mRNA abundance and protein content ", that the increased expression of MRF4 "induced myogenic cell differentiation and is expressed in developing muscle as it is directly related to muscle growth.".

I would like to know if that is right or wrong? Phate? MuscleScience? Want to explain?

Ok there was a key point left out there. It is talking about the developing muscle cell apparently. A myogenic cell or a Myogenic progenitor cell is basically a stem cell that is on its way to becoming a mature adult muscle cell.

For example satellite cells are mononuclear progenitor cells. They are basically a stem cell that is half way between a true none-differentiated stem cell and a mature muscle cell. Remember also that skeletal muscle fibers are multi-nuclear.