First clen cycle ever!!!!

[Mooseman33]

Greek,
who cares if u loose strength at this point. strip it down, then build it back even stronger.
u are trying to do to much at a time, start with loosing weight, stay on that diet and find a way to get some cardio in. yoga is not cardio.
give it time brother, then i promiss once u start to build the muscle again, u will be stronger then before....

[GREAKWESSNIPES]

Greek,
who cares if u loose strength at this point. strip it down, then build it back even stronger.
u are trying to do to much at a time, start with loosing weight, stay on that diet and find a way to get some cardio in. yoga is not cardio.
give it time brother, then i promiss once u start to build the muscle again, u will be stronger then before....

Yo MM.

I CARE!!!!!!!!

It took me longer 2 do my weights n I am a bit down coz of it!

Ashtanga n power yoga r full aerobic cardio workouts!

I am thinking of taking a PH to keep strength....

I read u can use them on less calz than aas!

I cannot run voz I have muscular lower back problems n i am scarted I will damage my eyes wit boxin/kickboxin!

I was thinkin of askin 4 a new diet with carbs!

RESPECT

[Phate]

Would u recommend ketotifen with clen?

Why does this forum's clen n clim profiles say to use Benadryl with em if it does didly squat with them?

What scientific studies have you found debunking this? I have seen many that explain the "up-regulating" actions of benedryl on beta-receptors...which is counteracts the "down-regulating" actions of clen on beta-receptors.

So why wouldn't this work? It makes perfect sense scientifically...

Here is a post by Ronnie Rowland from a thread he made a while ago

Clenbuterol can also cause a downregulation in testicular androgen receptors and in pulmonary, cardiac and central nervous system beta-adrenergic receptors(6.) possibly making steroids less effective (if there is androgen receptor downregulation elsewhere as well, then it´s highly probable) while you are on clen; but definitely making clen less effective as time goes on and you keep taking it. To counteract this, you can take some ketotifen every 3rd or 4th week that you remain on clen. It´s a prescription anti-histimines, so it´ll make you drowsy (take before bedtime). Basically, the way this works is to reduce beta-2 receptor activity, and restore receptor function (15).

Another option, if you are worried about receptor downgrade, is taking Benadryl, at around 50-100mgs/night before bed (every 3rd week or so, for that week). Benadryl is sold as an anti-histamine in the United States, and/or a sleep aid elsewhere in the world. However, Beta receptors are embedded in the cell´s outer phospholipid membrane. The stability of the membrane has a lot to do with the proper function of the receptors. Methylation of the phospholipids is stimulated by the binding of beta agonists to their receptors. Methylated phospholipids are foreign to the body, and when the body recognizes them as foreign, it breaks them down with phospholipase A2. This changes the structure of the outer membrane which results in desensitization of the beta receptors. On the other hand, agents that inhibit phospholipase A2 slow desensitization.

Cationic ampiphylic drugs are known for their ability to inhibit phospholipase A2. Benadryl (diphenhydramine) is a cationic ampiphylic drug.

Ergo, Benadryl slows desensitization of Beta receptors (i.e. Upgrades them) by inhibiting phospholipase A2, which is the enzyme that breaks down methylated phospholipids, and this action in turn keeps the phospholipid membrane stable, and thus keeps the receptors functioning properly. (7). This will allow you to use clen for much longer and it´ll still have the same effects. Also, since Benadryl is an anti-histamine, and histamines have a direct effect on beta-adrenoreceptors (not just Beta-2´s but all of them), using an anti-histamine will have a direct effect on reducing beta-receptor stimulation (16), and thus upregulating your beta-receptors.


MY RESPONSE TO THE ABOVE ARTICLE BELOW IN RED:

Methylation of phospholipids? Beta 1 and 2 receptors operate through a G-s transmembrane protein receptor which when activated by binding of a ligand results in stimulating Adenylate Cyclase. This 2nd messenger cascade converts ATP --> cAMP. The inc cAMP activates Protein Kinase A which then causes the physiological response observed in beta receptors. Beta 1 stimulation which are inc heart contractility, inc heart rate, inc lipolysis and inc renin release. Beta 2 stimulation results in inc heart contractility, inc heart rate, vasodilation of peripheral vessels, bronchodilation, inc lipolysis and inc glucagon release. Here's the funny thing....Renin release is associated with inc Angiotensin 2 levels which inc Aldosterone which is involved in Na+ and water retention.

[GREAKWESSNIPES]

Greek,
who cares if u loose strength at this point. strip it down, then build it back even stronger.
u are trying to do to much at a time, start with loosing weight, stay on that diet and find a way to get some cardio in. yoga is not cardio.
give it time brother, then i promiss once u start to build the muscle again, u will be stronger then before....

Yo MM.

I CARE!!!!!!!!

It took me longer 2 do my weights n I am a bit down coz of it!

Ashtanga n power yoga r full aerobic cardio workouts!

I am thinking of taking a PH to keep strength....

I read u can use them on less calz than aas!

I cannot run voz I have muscular lower back problems n i am scarted I will damage my eyes wit boxin/kickboxin!

I was thinkin of askin 4 a new diet with carbs!

RESPECT