The Scientific Research Thread For Anabolic Steroids

[Sauced_Up]

I wouldn't got that far as to think that its without bias and outside influence. I have been in primary research a long time and I can tell you there is considerable human influence in what gets published and what does not, regardless of the science. Case in point, the whole fiasco with the climate change data.
Granted I am not/was not involved in AAS research.

BTW, excellent thread!

Ok I may have overstated the possibility of influence and used my own experiences with research being conducted. Im sure you can agree that for research conducted by universities(as much of the worlds research is done in) and peer reviewed then published into medical journals, that there is a high regard for quality and accuracy in the experiments. Anyways thanks for the props on the thread!

[MuscleScience]

Ok I may have overstated the possibility of influence and used my own experiences with research being conducted. Im sure you can agree that for research conducted by universities(as much of the worlds research is done in) and peer reviewed then published into medical journals, that there is a high regard for quality and accuracy in the experiments. Anyways thanks for the props on the thread!

Yes, for the most part I agree with you. As you get farther along in the scientific field you will find, like other professions, that there is a certain degree of favoritism to towards certain ideas, concepts, labs, techniques and so on. A very famous snub as you may recall, is the work of Rosalind Franklin for no reason other than she was a women in a male dominated profession. This I think illustrates my point and shows that science is not devoid of the human element.

The peer-review process is the best and most methodical way to gain and verify information. I am in no way knocking it, its that fact that politics still interjects time to time in research and it can be from many different levels. From the grad student doing the grunt work all the way up to the organization providing funding to the lab. Knowing the limitations in the process makes one a better scientist and skeptic alike.

[Sauced_Up]

Thank you my Endo likes to see real studies and then we discuss it send it to him see what he has to say.

No prob, ill keep updating this thread so if you got any other requests, throw them at me

Yes, for the most part I agree with you. As you get farther along in the scientific field you will find, like other professions, that there is a certain degree of favoritism to towards certain ideas, concepts, labs, techniques and so on. A very famous snub as you may recall, is the work of Rosalind Franklin for no reason other than she was a women in a male dominated profession. This I think illustrates my point and shows that science is not devoid of the human element.

The peer-review process is the best and most methodical way to gain and verify information. I am in no way knocking it, its that fact that politics still interjects time to time in research and it can be from many different levels. From the grad student doing the grunt work all the way up to the organization providing funding to the lab. Knowing the limitations in the process makes one a better scientist and skeptic alike.

Very true, thanks again MS

[MuscleScience]

No prob, ill keep updating this thread so if you got any other requests, throw them at me



Very true, thanks again MS

No Thank You!

This is one of the most thought provoking threads we have had in awhile. I can say myself, that some of these studies got my wheels turning in my head.

[Sauced_Up]

Testosterone Threshold Levels and Lean Tissue Mass Targets Needed to Enhance Skeletal Muscle Strength and Function: The HORMA Trial.

Sattler F, Bhasin S, He J, Chou CP, Castaneda-Sceppa C, Yarasheski K, Binder E, Schroeder ET, Kawakubo M, Zhang A, Roubenoff R, Azen S.

Department of Medicine, University of Southern California, 2020 Zonal Avenue, Room 434, Los Angeles, CA 90033.
J Gerontol A Biol Sci Med Sci. 2010 Nov 8.

Abstract
BACKGROUND: In the HORMA (Hormonal Regulators of Muscle and Metabolism in Aging) Trial, supplemental testosterone and recombinant human growth hormone (rhGH) enhanced lean body mass, appendicular skeletal muscle mass, muscle performance, and physical function, but there was substantial interindividual variability in outcomes.

METHODS: One hundred and twelve men aged 65-90 years received testosterone gel (5 g/d vs 10 g/d via Leydig cell clamp) and rhGH (0 vs 3 vs 5 μg/kg/d) in a double-masked 2 × 3 factorial design for 16 weeks. Outcomes included lean tissue mass by dual energy x-ray absorptiometry, one-repetition maximum strength, Margaria stair power, and activity questionnaires. We used pathway analysis to determine the relationship between changes in hormone levels, muscle mass, strength, and function.

RESULTS: Increases in total testosterone of 1046 ng/dL (95% confidence interval = 1040-1051) and 898 ng/dL (95% confidence interval = 892-904) were necessary to achieve median increases in lean body mass of 1.5 kg and appendicular skeletal muscle mass of 0.8 kg, respectively, which were required to significantly enhance one-repetition maximum strength (≥30%). Co-treatment with rhGH lowered the testosterone levels (quantified using liquid chromatography-tandem mass spectrometry) necessary to reach these lean mass thresholds. Changes in one-repetition maximum strength were associated with increases in stair climbing power (r = .26, p = .01). Pathway analysis supported the model that changes in testosterone and insulin-like growth factor 1 levels are related to changes in lean body mass needed to enhance muscle performance and physical function. Testosterone's effects on physical activity were mediated through a different pathway because testosterone directly affected Physical Activity Score of the Elderly.

CONCLUSIONS: To enhance muscle strength and physical function, threshold improvements in lean body mass and appendicular skeletal muscle mass are necessary and these can be achieved by targeting changes in testosterone levels. rhGH augments the effects of testosterone. To maximize functional improvements, the doses of anabolic hormones should be titrated to achieve target blood levels.