Quote Originally Posted by Lemonada8 View Post
That doesnt make sense... beta1 and beta2 have the same 2nd messanger cAMP. How can it be agonist for one and no agonist properties for the other? If beta selective were so selective for no cross activation, then why arent all asthma meds a pill? thats cuz they arent. They can modify it so its not as selective but there will be some cross activation. also, thermo genics is mainly beta3 receptor which clen is a thermogenic.
^^^ How can it not make sense - its called selective - not exclusive - look at the bigger picture and think about it for a minute. There are a slew of selective beta receptor agents (think beta blaockers). These agents exist for b1 - b2 - b3 receptors. Some are so selective ( even exclusive) that they are used in experimentation due to there extreme specificity. Also stop think in absolutes such as "no agonist" and stick to what i said "virtually no agonist" - ie - no clinically significant agonist activity. Also the same can be said for clens b3 agonist effects. While they exist it is to a lesser degree. Also just because cAMP is second messeneger for b1 and b2 far from means the same agonist activity is exerted on boith - you know that. I personally would say clens effects are primarily exerted on b2 ...then to a lesser extent b3 ...then minimally on b1 . Thats just my opinion - but I think its pretty damn sound based on science and experience.