My first cycle. Will log each pinning day. AI questions

[ZoomyR6]

I’m no authority on this, but it’s my understanding that an AI won’t make gyno symptoms go away. Nolva would be used for that, assuming the symptoms haven’t been present for a long period of time.

This is what I have been confused about. If e2 is responsible for gyno, and you eventually bring e2 down via AI before lumps appear, how could it not???

[cousinmuscles]

This is what I have been confused about. If e2 is responsible for gyno, and you eventually bring e2 down via AI before lumps appear, how could it not???

Nolvadex antagonizes the effects of estrogen in breast tissue specifically. Bringing down E2 with an AI would mean bringing down serum E2 (systemic not local) probably means you have to keep your estrogen too low. Why let E2 go so high to begin with?

[ZoomyR6]

Nolvadex antagonizes the effects of estrogen in breast tissue specifically. Bringing down E2 with an AI would mean bringing down serum E2 (systemic not local) probably means you have to keep your estrogen too low. Why let E2 go so high to begin with?

Well the nolva reasoning I get.
Some people, myself included, would rather do without an AI unless absolutely needed. As soon as symptoms of elevated e2 appear (ie; bloating, libido issues, irritability, hot flashes, facial flushing), then start taking it. I for one had my e2 at 113 (15-29) when I was having those symptoms from trt and hcg until I went on an AI and had no gyno symptoms at that level.

Wouldn't gyno symptoms stop once the e2 in under control, regardless if it's lowered systemic or not?

[cousinmuscles]

Well the nolva reasoning I get.
Some people, myself included, would rather do without an AI unless absolutely needed. As soon as symptoms of elevated e2 appear (ie; bloating, libido issues, irritability, hot flashes, facial flushing), then start taking it. I for one had my e2 at 113 (15-29) when I was having those symptoms from trt and hcg until I went on an AI and had no gyno symptoms at that level.

Wouldn't gyno symptoms stop once the e2 in under control, regardless if it's lowered systemic or not?

A friend of mine once wanted to take the letrozole route for gyno. It helped only a little and didn't get rid of his gyno completely. He ended up getting gyno again later. I'd use the search function for more info...