To the DIET drinkers... and the rest aswell

[Ziggywizz]

http://video.google.com/videoplay?do...37323833021886

for you guys who likes to drink diet stuff. its a long film and kinda slow at the beggining but if you see the thing you will know wht i mean. acutually i,m living proof. 1 suicide attempt, and an all out social and general anxeity after getting diabetes and going on the diett shit...

flame me all you want i dont give a shit... i,m just saying this is it. some of you wont believe it, thats fine but its ruined my life. maybe posting this film can prevent some wouldbe poor bastard of making the same mistakes i did... then i,ve done the right thing.

[*Narkissos*]

*reaches for diet coke and watches*

[Ziggywizz]

well then i hope you enjoy it

[BajanBastard]

Is this more 'diet drinks are deadly' propaganda by the sugar industry?

[*Narkissos*]

Is this more 'diet drinks are deadly' propaganda by the sugar industry?

I think it started talking about aspartame's danger to individuals unable to metabolise phenylalanine.

Then i got bored (sorry short attention span) and switched to something else.

It's 1 hour and 30 minutes long for pete's sake.

[hardgainer12]

i hate this crap.......sorry

[stunner5000pt]

I think it started talking about aspartame's danger to individuals unable to metabolise phenylalanine.

Then i got bored (sorry short attention span) and switched to something else.

It's 1 hour and 30 minutes long for pete's sake.

that's TOO DAMN LONG

for now diet coke is how im going to satisfy my sweet tooth

[ascendant]

see, this is the kind of sh*t i've been telling people about for about a year now. ever since i researched aspartame, i've found all kinds of information from innumerable sources indicating it's toxicity. even the fda themselves admitted to me that the animal testing done indicated numerous health problems. of course they failed to answer why it is that it made it to the market despite those tests indicating potential serious dangers, but that's the fda for you.

when there's as much controversial concerns over a product as there is over this one, you can just about guarantee there is something to be concerned about. the concerns with smoking began very similarly. eventually, it got to the point where so many people knew it could no longer be hidden from the general public. in time, we'll find the same with aspartame. my only concern is how much damage it will cause before that happens. the saddest thing is you know even after the company admits to their being health issues associated with their product, the fda will still not remove it from the market. there's too much money to be lost, just as there was with removing cigarettes from the market. just like cigarettes as well, sadly there will still be people out there knowing without question the kind of health issues aspartame causes drinking it regardless.

what i'd like to know for all those that think aspartame is harmless is what makes you think it is? what information provided by someone other than those having a financial interest in the aspartame has claimed they know without question it does not cause health issues?

in every single study in every test done with the product, it has always caused numerous serious health issues in test subjects. even those supporting it's use can't deny that, they simply try to justify it with "well the average human doesn't consume as much as we used in the tests". regardless, the tests showed potential dangers and it was still released onto the market, and year after year the fda continues to disregard complaints from consumers regarding side-effects from it's consumption. when you look into it and find out what went down with all of it, it's a really sick story.

[Warrior]

*reaches for diet coke and watches*

Hehe

This aspartame thing is all hype - you need to drink a lot of it to get the potential health risk... and as we all know, too much of anything is simply not healthy.

In all honestly I don't think you can target drinking diet sodas for your anxiety problems and suicidal tendencies. Used in moderation, artificial sweetners are very helpful in regulating calorie intake for managing body mass. But I guess as any good guniea pig I can't completely rule out the possiblity...

[ascendant]

alright, just realized that prior to me putting up my last post, there were several people posting that they thought the negative health claims regarding aspartame were bs. no offense to anyone, but what in your right mind made you think that?

again, show me one single study that has shown it to be safe? go ahead and call the fda yourself and ask them about the animal testing done with aspartame and you can hear first hand all the negative health effects it had on the animals.

i don't understand why so many of you just blow this information off? do you guys still think cigarettes are safe for you too? you think that's just hype as well? cmon.

why would anyone have such an interest in shooting down just one particular company like this? other than msg, hydrogenated oils, and aspartame, tell me of what else is criticized this much? msg and hydrogenated oils BOTH started out as rumors which were later proven to be true. aspartame has been proven to be dangerous ever since the beginning, yet the general public has disregarded that fact. i ask why?

[BajanBastard]

What's causing the most health problems in the USA? Artificial sweeteners? Or high fructose corn syrup and other sugars?

[ascendant]

Hehe

This aspartame thing is all hype - you need to drink a lot of it to get the potential health risk... and as we all know, too much of anything is simply not healthy.

In all honestly I don't think you can target drinking diet sodas for your anxiety problems and suicidal tendencies. Used in moderation, artificial sweetners are very helpful in regulating calorie intake for managing body mass. But I guess as any good guniea pig I can't completely rule out the possiblity...

sorry bro but i have to completely disagree. it is not hype and once again, just call the fda and you'll find my statements to be accurate. again, every single study done on aspartame has shown serious potential health risks.

as far as using it in moderation, a toxin in moderation is still a toxin. cigarettes carry literally over 100 toxins in them in very minute doses. now according to the companies, they claimed for years that since it was such miniscule doses, it was ok. however, countless studies later brought out the innevitable truth about it.

there are plenty of artifical sweeteners that are completely safe. stevia extract is a perfect example of one.

i would have to ask you guys why would so many biochemists, doctors, and others who specialize in fields with exceptional knowledge about products like this be so focused on attacking just this one particular food additive? you really think you guys know better than a biochemist when it comes to chemicals?

oh, had to edit to add this in as well in regards to your remark about having to consume a lot to get the potential health risk. first, if you need to consume THAT much, why are so many people having so many reported negative health effects associated with aspartame? additionally, ever look into how long it takes for the by-products of aspartame to be completely removed from your body? they build up over time bro. just as cigarette toxins build up over time, so does the toxins from aspartame. it's all a matter of time.

[Ziggywizz]

What's causing the most health problems in the USA? Artificial sweeteners? Or high fructose corn syrup and other sugars?

who has said anything about sugar beeing any better? and also what do you mean propaganda from the sugar industry.. coka cola dont make diet and regular soda drinks?? c,mon man....

[ascendant]

What's causing the most health problems in the USA? Artificial sweeteners? Or high fructose corn syrup and other sugars?

well the corn syrup and other sugars cause a predictable negative health effect, obesity. when overconsuming products with sugars in them, you see the negative side-effects first hand in weight gain.

with the artificial sweeteners, how can you know when you're consuming too much? though two of the three ingredients in it are amino's, one is an excitotoxin. this allows the protein to enter neural pathways of the brain unhindered, which is why the negative health effects of this product is so unpredictable.

if you simply research the chemicals that aspartame breaks down into, it's clear as day what kinds of negative health effects they can cause. though the effects are highly unpredictable, they are clearly a potential danger.

[Warrior]

Are you saying Aspartame should be avoided at all costs? In the video (toward the end) they do mention that the studies need to be improved to create a real conclusion to it all. If Aspartame becomes a major toxin - I am sure the surgeon general would intervene... or at least make a statement on all products containing the additive...

how you live your life in general is a major health variable. Being inactive, unproductive, unsuccessful, out-of-shape and fat, too many trans/saturated fats, an overload of fructose and simple sugars... this is an accumulative major health risk.

[abcde]

see, this is the kind of sh*t i've been telling people about for about a year now. ever since i researched aspartame, i've found all kinds of information from innumerable sources indicating it's toxicity. even the fda themselves admitted to me that the animal testing done indicated numerous health problems. of course they failed to answer why it is that it made it to the market despite those tests indicating potential serious dangers, but that's the fda for you.

when there's as much controversial concerns over a product as there is over this one, you can just about guarantee there is something to be concerned about. the concerns with smoking began very similarly. eventually, it got to the point where so many people knew it could no longer be hidden from the general public. in time, we'll find the same with aspartame. my only concern is how much damage it will cause before that happens. the saddest thing is you know even after the company admits to their being health issues associated with their product, the fda will still not remove it from the market. there's too much money to be lost, just as there was with removing cigarettes from the market. just like cigarettes as well, sadly there will still be people out there knowing without question the kind of health issues aspartame causes drinking it regardless.

what i'd like to know for all those that think aspartame is harmless is what makes you think it is? what information provided by someone other than those having a financial interest in the aspartame has claimed they know without question it does not cause health issues?

in every single study in every test done with the product, it has always caused numerous serious health issues in test subjects. even those supporting it's use can't deny that, they simply try to justify it with "well the average human doesn't consume as much as we used in the tests". regardless, the tests showed potential dangers and it was still released onto the market, and year after year the fda continues to disregard complaints from consumers regarding side-effects from it's consumption. when you look into it and find out what went down with all of it, it's a really sick story.

You are right on...unfortunately, it has everything to do with $$$ and the "out-of-control" lack of ethics/morals in our present economic system.

[ascendant]

Are you saying Aspartame should be avoided at all costs? In the video (toward the end) they do mention that the studies need to be improved to create a real conclusion to it all. If Aspartame becomes a major toxin - I am sure the surgeon general would intervene... or at least make a statement on all products containing the additive...

how you live your life in general is a major health variable. Being inactive, unproductive, unsuccessful, out-of-shape and fat, too many trans/saturated fats, an overload of fructose and simple sugars... this is an accumulative major health risk.

well, just as a cigarette every couple of days or so will most likely not cause any serious health issues, most likely aspartame in very low consumption wouldn't either. but honestly is it worth the risk?

to be honest, i didn't watch that movie all the way to the end yet. i watched about half and had already heard all this information from other sources already. my advice to you bro is if you're gonna keep consuming it, just do the research yourself and at least make an informed decision. i'm just trying to look out for you guys here.

as far as the surgeon general intervening, look at how well that did with cigarettes. aspartame won't be removed from the market so long as the fda has such a financial interest in it. besides, look how long cigarettes were on the market until the truth finally came out about them. sorry to keep making the comparison to cigarettes, but it's the best basis of comparison to the current situation that i have.

as far as it being an accumulative health risk, for most people that is true. however, it all depends on your sensitivity to the product. remember that one of the aminos in it is an excitotoxin which is permitted to travel into the neural pathways. also the methanol (think that's what it's called?) product in it converts into fermaldehyde in the body. you really don't know what your tolerance levels will be until you're already suffering the side-effects.

[Warrior]

What's causing the most health problems in the USA? Artificial sweeteners? Or high fructose corn syrup and other sugars?

SURGEON GENERALS WARNING: Living you life is a major cause of death. Killing yourself now may reduces serious risks to your health.

The irony is artificial sweetners were developed to solve health issues related to high sugar intake. It seems no matter what comes out - wait a few years and it will be linked to your death. Moderation is and will always be key.

You can live your entire life on whole natural foods with plenty of exercise and a successful life. And then your neighbor thinks bacon is too lean and filtered cigarettes are too weak - outlives you! Pfft...

For example...

My father (a German farm kid turned city slicker): smoking Pall Mall nonfilter cigarettes since he was about 9 years old, drinking Johhny Walker Whiskey everyday for years (certified alcholic), loves eating the fat off of steak, was active and strong but is now overweight and basically lazy, never remarried and has lived a life of an unpredictable salesman... currently, no major health issues.

My step-father (raised in an all American suburb), eats a lot of natural and "health" foods, active outdoors man (hunter, fishing) and lives a stress free successful marriage and life. He has been successfully fighting prostate cancer for 10 years now but recently just got diagnosed with a malignant stomach tumor and has spent the last several weeks walking around with a cathader...

[Ziggywizz]

some people are just born up thight... drink away and enjoy... like i have anything to gain by less sales of diet products...

[Warrior]

Phenylalanine - Aspartame

Nutrition fact about Phenylalanine in aspartame:

The 1976 Groliers encyclopedia states cancer cannot live without phenylalanine. Phenylalanine makes up 50% of aspartame.

Phenylalanine is one of the essential amino acids found in proteins, but I am one of the believers that amino acids should be eaten in combination, not in isolated form. Nature provides amino acids in combination; only man isolates them for processing purposes.

Phenylalanine is found naturally in foods such as eggs, milk, bananas, and meat. If you are PKU (Phenylketonuric) or sensitive to phenylalanine, you will react to the phenylalanine in aspartame. You may want to get a blood test to check for this condition. Over the past 20 years, humans have become more aware of PKU reactions because human beings began using isolated phenylalanine to the degree it is harmful to some individuals, many as aspartame side effects. My suggestion would be to research PKU and phenylalanine extensively. Phenylalanine can be very harmful to diabetics.
Read all food labels and avoid anything with isolated amino acids. You want to buy products with at least eight amino acids in combination.

Aspartame Myths: Phenylketonuria

Phenylketonuria (PKU) is a rare inherited disease that prevents the essential amino acid phenylalanine from being properly metabolized. (An essential amino acid is required for normal growth, development, and body functioning and must be obtained from the diet, as the body cannot make it.) Because of this, phenylalanine can accumulate in the body and cause health problems including mental retardation. In the U.S. and many other countries, routine screening for PKU is required for all newborns. In the U.S., about 1 in 15,000 babies is born with PKU. People with PKU are placed on a special diet with a severe restriction of phenylalanine from birth to adolescence or after. Women with PKU must remain on the special diet throughout pregnancy. Since individuals with PKU must consider aspartame as an additional source of phenylalanine, aspartame-containing foods must state "Phenylketonurics: Contains Phenylalanine" in the U.S.

[Mizfit]

ok here is the deal.. you drink too much sugar your gonna die.. you drink asparatame.. your gonna die..

You have to make choices.. I make choices that reflect my lifestyle and the quality of life i want to lead... i like diet coke and crystal lite and i do not drink water.. do you hear me YES I hate the taste of water.. fine i realize that this is unheard of.. but i just can not drink it and will not drink it even if it is the only thing that is offered to me.

Live you life in fear poster

[Mizfit]

Hey just a question.. i left my house and used a metal key - will i die of lead poisnoning - please do some research for me...

[Ziggywizz]

Hey just a question.. i left my house and used a metal key - will i die of lead poisnoning - please do some research for me...

stupid question. are you trying to be funny.. the problem here is that aspartame is beeing sold as something harmless, when it is not.

[Mizfit]

stupid question. are you trying to be funny.. the problem here is that aspartame is beeing sold as something harmless, when it is not.

There is harm everywhere.. and no it is not being sold as completely harmeless.. its an option..

Are there warnings on sugar? Are there warnings on other foods.. no .. so why on asparatame?

[Ziggywizz]

like i said enjoy then.. still no way you can compare it with sugar..
debate all you want, but i still recommend taking the time to see the video if you do consume diet products so you have some more informasjon besides the official studies financed by the same companies making these products.

[SwoleCat]

What's causing the most health problems in the USA?

Threads like this.

~SC~

[STYLE74]

I think it's true...i just drank a diet snapple and i wanna jump off a bridge!!!

[Dave321]

what would you say about sucralose? same hazards? or other "diet form sugars?"

[SwoleCat]

I just had 2 cups of coffee w/splenda......

Time to slit the wrists.

~SC~

[oldman]

Okay let me ask this because this is along the same line. My parents and grandmother (she was diabetic) used SweetNLow (saccharin) for ever and ever and never got sick from it.. Hell its be out since the 50's and all the gloom and doom about it causing cancer. Well I have been using it since I was a little kid too, my parents did not want to give us a lot of sugar when we drank ice tea and stuff and now 30+ years of that stuff I am still healthy.

I guess my family is just lucky? On just about every product on the market there will be people for and against it on health concerns.

Let me ask this to those against sweeteners do you eat pickles or anything pickled?

~Old

[Mizfit]

like i said enjoy then.. still no way you can compare it with sugar..
debate all you want, but i still recommend taking the time to see the video if you do consume diet products so you have some more informasjon besides the official studies financed by the same companies making these products.

hmm women give men headaches.. but they keep comin back

[anaBROLIC]

Threads like this.

~SC~

..

[ascendant]

i just don't get the majority of the mentalities on this matter.

you guys will tear someone up for having a bad diet which could be something as simple as them having too much fat or too little protein, but you disregard warnings about potentially deadly substances? i'm finding a lot of people i normally see eye to eye with being quite ignorant to the facts here.

the justification of aspartames consumption by indicating anything can kill you is ridiculous. it's cumulative guys. the more things you do that are serious risks to your health, the greater the chances of something happening. cigarettes and aspartame are both serious risks to your health. just as smokers try to blow off the consequences of their addiction to justify it's use, it seems many of you are blowing off the concerns about aspartame to justify it's consumption as well.

also, lets try to stick with better basis of comparison here guys. not to mention names, but some of you seem to be acting like you shouldn't worry about aspartame cause anything can kill you. well, it's about probabilities. if i drive my car to work at an average speed of 55mph, there's a very slight probability i'll get in a fatal accident on the way. however, if i decide to drive an average speed of 140mph on the way to work as i'm driving, i'm greatly increasing that probability of me getting in a fatal accident. common sense tells you that even though anything can kill you, doing certain things can greatly increase that probability. why do so many of you try to make a joke out of it by comparing aspartame to for example, a key? it's not about living in fear, it's about living sensibly.

for me personally, there are a select few things that i avoid in foods cause of how bad the health risks are. they are msg, hydrogenated oils, and aspartame. now, if avoiding those 3 things cause i know how bad they are for you is "living in fear", then go ahead and call it that.

though many of you can say you've consumed aspartame for years and have had no serious side-effects, what about the minor ones? how can you really know it isn't affecting your quality of life in some way? the excitoxin in it does have a direct impact on your brain, so as far as you know it could affect something such as your short-term or long term memory, but you'd never really notice unless you stopped taking it and watched your memory improve. also, the side effects of aspartame are so varied that it's very hard to pinpoint exactly what's related to it and what isn't. for all you know, those headaches you get are from the aspartame, or the stomach aches, the occasional depression, anxiety, etc.

for those of you who think avoiding things cause of health risks is ridiculous, go ahead and smoke, drink alcohol, drink aspartame, eat foods with msg and hydrogenated oils, and enjoy. you may very well live a long, full life. however, as i already stated, you'll greatly decrease your probability of it by consuming these things. there are some things that i do believe people worry too much about. however, aspartame is far from one of them.

if they put something with minute amounts of arsenic on the market, would you same people taking aspartame take arsenic as well? they're both toxins, so why not? use your heads guys, this isn't something that people are being overconcerned about. it's a genuine concern of something on the market that is deadly that's concealed as something healthy.

there are plenty of artificial sweetener alternatives to aspartame that are completely safe, so it's not like you have to choose between aspartame or sugar. additionally, you don't even have to choose any at all! you can consume something entirely different. however, if your lack of will or desire inhibits you to do so, then maybe that's part of your justification behind blowing off the health concerns of aspartame? regardless, the "choice" of aspartame or sugar is not a justification for it's marketing cause there doesn't have to be a choice. you don't need either one and can do perfectly fine without it.

look, before you go blowing off the health claims, just do the research. that's all you need to do. for you to blow off the health concerns of aspartame is like blowing off the concerns of cigarettes. seriously, aspartame is no better than them. if anything, it's worse.

if you don't care to look into it cause you wanna keep taking it and are concerned of what you'd learn if you seriously looked into it, then just simply state that you don't care and leave it at that. but i have to request that you guys please stop making a joke out of it as you're not "funny", not "cool", and despite that being the seemingly popular thing to do here, it's not the smartest and you're exposing that every time you post without justification behind your statements.

this post and the information accompanying it can seriously help a lot of people realize a seroius potential danger in many food products on the market nowadays, and by you mocking it, you may very well make someone overlook that fact and end up suffering the health consequences down the road because of it. is that what you want to do to your fellow members here? i sure don't cause i'm trying to help.

[SwoleCat]

One day you hear "this" in the media, tomorrow you hear "that".

EX:

Eggs were once thought to be horrible for you, now we know that not to be true. Your body produces 1/2 of it's cholesterol on it's own, so dietary intake is not where the issue lies.

I don't spend too much time worrying over things like this, but if it's something you are passionate about, then please enjoy.

~SC~

[oldman]

Well your concerns to you are valid to others they are not. Basically if we do not agree with your views we are stupid, clueless and/or just are not bright enough to care based on your first sentence above.

Come on bro you and 90+% of the people on this site stick all kinds of other chemicals into our bodies and you are not saying anything about that. Is Tren , VAR, DBOL , DROL, HCG , all good for you or does it have some sort of side effect (other than growing big)? It can have an effect on blood lipid profile and cause heart disease if you do not keep things in check and with adbuse or none proper use of PCT it could cause more problems than a diet coke every will. What about eating fried foods? What about Pickles that have been proven to be carcinogenic, what about those here that smoke pot? what about those that drink alcohol is that good for you? what about all those things?

Dude it is great you are trying to put your side and thoughts here but don't preach to people that don't want to be preached to. If you have an idea post it but don't get mad when everyone does not agree with you.

~Old

[SwoleCat]

For real, well said Oldman!



~SC~

[STYLE74]

SURGEON GENERALS WARNING: Living you life is a major cause of death. Killing yourself now may reduces serious risks to your health.

The irony is artificial sweetners were developed to solve health issues related to high sugar intake. It seems no matter what comes out - wait a few years and it will be linked to your death. Moderation is and will always be key.

You can live your entire life on whole natural foods with plenty of exercise and a successful life. And then your neighbor thinks bacon is too lean and filtered cigarettes are too weak - outlives you! Pfft...

For example...

My father (a German farm kid turned city slicker): smoking Pall Mall nonfilter cigarettes since he was about 9 years old, drinking Johhny Walker Whiskey everyday for years (certified alcholic), loves eating the fat off of steak, was active and strong but is now overweight and basically lazy, never remarried and has lived a life of an unpredictable salesman... currently, no major health issues.

My step-father (raised in an all American suburb), eats a lot of natural and "health" foods, active outdoors man (hunter, fishing) and lives a stress free successful marriage and life. He has been successfully fighting prostate cancer for 10 years now but recently just got diagnosed with a malignant stomach tumor and has spent the last several weeks walking around with a cathader...

You are right on warrior!!! My grandfather smoked his whole life and lived until 86 years old yet Dana Reeves who never smoked a cigarette in her live died of lung cancer at such an early age. When it's time to go it's time to go and only god knows who's going next. Everything that we enjoy is bad for us so as long as we enjoy things in moderation we should be fine.

[STYLE74]

Well your concerns to you are valid to others they are not. Basically if we do not agree with your views we are stupid, clueless and/or just are not bright enough to care based on your first sentence above.

Come on bro you and 90+% of the people on this site stick all kinds of other chemicals into our bodies and you are not saying anything about that. Is Tren , VAR, DBOL , DROL, HCG , all good for you or does it have some sort of side effect (other than growing big)? It can have an effect on blood lipid profile and cause heart disease if you do not keep things in check and with adbuse or none proper use of PCT it could cause more problems than a diet coke every will. What about eating fried foods? What about Pickles that have been proven to be carcinogenic, what about those here that smoke pot? what about those that drink alcohol is that good for you? what about all those things?

Dude it is great you are trying to put your side and thoughts here but don't preach to people that don't want to be preached to. If you have an idea post it but don't get mad when everyone does not agree with you.

~Old

BUMP

[novastepp]

i like to discuss things and read opinions, butthat's what everything is now...speculation. we eat food that s grwn from artificial hormones, water that has a high level of radiation exposed to it to purify it...like good ol' Forest Gump said, "Sh*t Happens". nd it is always a personal choice ow you live with it.

[DNoMac]

I use Sucralose, but for those who like aspartame, this is what I found:

Cesare Maltoni Cancer Research Center, European Ramazzini Foundation of Oncology and Environmental Sciences, Bologna, Italy. [email protected]

The Cesare Maltoni Cancer Research Center of the European Ramazzini Foundation has conducted a long-term bioassay on aspartame (APM), a widely used artificial sweetener. APM was administered with feed to 8-week-old Sprague-Dawley rats (100-150/sex/group), at concentrations of 100,000, 50,000, 10,000, 2,000, 400, 80, or 0 ppm. The treatment lasted until natural death, at which time all deceased animals underwent complete necropsy. Histopathologic evaluation of all pathologic lesions and of all organs and tissues collected was routinely performed on each animal of all experimental groups. The results of the study show for the first time that APM, in our experimental conditions, causes a) an increased incidence of malignant-tumor-bearing animals with a positive significant trend in males (p < or = 0.05) and in females (p < or = 0.01), in particular those females treated at 50,000 ppm (p < or = 0.01); b) an increase in lymphomas and leukemias with a positive significant trend in both males (p < or = 0.05) and females (p < or = 0.01), in particular in females treated at doses of 100,000 (p < or = 0.01), 50,000 (p < or = 0.01), 10,000 (p < or = 0.05), 2,000 (p < or = 0.05), or 400 ppm (p < or = 0.01); c) a statistically significant increased incidence, with a positive significant trend (p < or = 0.01), of transitional cell carcinomas of the renal pelvis and ureter and their precursors (dysplasias) in females treated at 100,000 (p < or = 0.01), 50,000 (p < or = 0.01), 10,000 (p < or = 0.01), 2,000 (p < or = 0.05), or 400 ppm (p < or = 0.05); and d) an increased incidence of malignant schwannomas of peripheral nerves with a positive trend (p < or = 0.05) in males. The results of this mega-experiment indicate that APM is a multipotential carcinogenic agent, even at a daily dose of 20 mg/kg body weight, much less than the current acceptable daily intake. On the basis of these results, a reevaluation of the present guidelines on the use and consumption of APM is urgent and cannot be delayed.