Gene mutation makes baby super strong

**Devils Mentor** · 07-31-2007, 07:56 AM

I original Posted this in another Forum that I am a Member of, because it relates to an Article that was posted about a Double Muscle Dog... I included that Article as well...

Enjoy...

This is on the lines of the Arnold Dog with Double Muscles:

http://alinboard.com/showthread.php?t=9785

I was just doing some research into finding one of the Whipple Dog from the above thread, which led me into looking up info on Myostatin Blockers, which led me to the Baby... Blah... Now that that is over, lol...

Here is the Article:

http://www.chinadaily.com.cn/english...ent_342496.htm

Gene mutation makes baby super strong
(Agencies)
Updated: 2004-06-25 09:00

Somewhere in Germany is a baby Superman, born in Berlin with bulging arm and leg muscles. Not yet 5, he can hold seven-pound weights with arms extended, something many adults cannot do. He has muscles twice the size of other kids his age and half their body fat.

DNA testing showed why: The boy has a genetic mutation that boosts muscle growth.

The discovery, reported in Thursday's New England Journal of Medicine, represents the first documented human case of such a mutation.

Many scientists believe the find could eventually lead to drugs for treating people with muscular dystrophy and other muscle-destroying conditions. And athletes would almost surely want to get their hands on such a drug and use it like steroids to bulk up.

The boy's mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. The news comes seven years after researchers at Johns Hopkins University in Baltimore created buff "mighty mice" by "turning off" the gene that directs cells to produce myostatin.

"Now we can say that myostatin acts the same way in humans as in animals," said the boy's physician, Dr. Markus Schuelke, a professor in the child neurology department at Charite/University Medical Center Berlin. "We can apply that knowledge to humans, including trial therapies for muscular dystrophy."

Disease relief

Given the huge potential market for such drugs, researchers at universities and pharmaceutical companies already are trying to find a way to limit the amount and activity of myostatin in the body. Wyeth has just begun human tests of a genetically engineered antibody designed to neutralize myostatin.

A seven-month old baby with a genetic mutation that boosts muscle growth is seen in an undated black and white image released by the New England Journal of Medicine on Wednesday June 23, 2004. The discovery, reported in Thursday's New England Journal of Medicine, represents the first documented human case of such a mutation. The boy's mutant DNA segment was found to block production of a protein called myostatin that limits muscle growth. [AP]
Dr. Lou Kunkel, director of the genomics program at Boston Children's Hospital and professor of pediatrics and genetics at Harvard Medical School, said success is possible within several years.

"Just decreasing this protein by 20, 30, 50 percent can have a profound effect on muscle bulk," said Kunkel, who is among the doctors participating in the Wyeth research.

Muscular dystrophy is the world's most common genetic disease. There is no cure and the most common form, Duchenne's, usually kills before adulthood. The few treatments being tried to slow its progression have serious side effects.

Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS.

"If you could find a way to block myostatin activity, you might slow the wasting process," said Dr. Se-Jin Lee, the Johns Hopkins professor whose team created the "mighty mice."

Lee said he believes a myostatin blocker also could suppress fat accumulation and thus thwart the development of diabetes. Lee and Johns Hopkins would receive royalties for any myostatin-blocking drug made by Wyeth.

Boy's background, future

Dr. Eric Hoffman, director of Children's National Medical Center's Research Center for Genetic Medicine, said he believes a muscular dystrophy cure will be found, but he is unsure whether it will be a myostatin-blocking drug, another treatment or a combination, because about a dozen genes have some effect on muscles.

He said a mystotatin-blocking drug could help other groups of people, including astronauts and others who lose muscle mass during long stints in zero gravity or when immobilized by illness or a broken limb.

Researchers would not disclose the German boy's identity but said he was born to a somewhat muscular mother, a 24-year-old former professional sprinter. Her brother and three other close male relatives all were unusually strong, with one of them a construction worker able to unload heavy curbstones by hand.

In the mother, one copy of the gene is mutated and the other is normal; the boy has two mutated copies. One almost definitely came from his father, but no information about him has been disclosed. The mutation is very rare in people.

The boy is healthy now, but doctors worry he could eventually suffer heart or other health problems.

In the past few years, scientists have seen great potential in myostatin-blocking strategies.

Internet marketers have been hawking "myostatin-blocking" supplements to bodybuilders, though doctors say the products are useless and perhaps dangerous.

Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

Ciao,

DM

**K.Biz** · 07-31-2007, 08:05 AM

I have read both of these, im still waiting for the myostatin blocker myself.... in 2004 they said its only a couple of years away... well it been a couple years lol

**IronReload04** · 07-31-2007, 09:48 AM

this is the second baby i have heard about

THe other buddy is an american i believe, looks liek he is of african decent. his legs and arms have insane muscle density and thickness. he had basically very low bodyfat........He was also quite sick for awhile after birth....He couldnt hold food down at all, I think he might have had heart problems too. IF these kids get to average height, we are going to have some freaks on our hands

**IronReload04** · 07-31-2007, 09:50 AM

I really hope the m blocker never makes it to bodybuilding.......At least with roids and whats out now, you still need elite genetics to look elite

**Lexed** · 07-31-2007, 10:20 AM

dam thats crazy

**crazyhorse666** · 07-31-2007, 01:05 PM

wow I hope some day I can get some

**lightwaytbaby** · 07-31-2007, 03:42 PM

Originally Posted by K.Biz

I have read both of these, im still waiting for the myostatin blocker myself.... in 2004 they said its only a couple of years away... well it been a couple years lol

x2!!!

**PEWN** · 07-31-2007, 03:49 PM

sign me up for the first perscription....

**RBD85** · 07-31-2007, 04:31 PM

Pshhh I could take him...

**lightwaytbaby** · 07-31-2007, 06:29 PM

Originally Posted by R**85

Pshhh I could take him...

That baby would kick your ass and you know it!

**RBD85** · 07-31-2007, 09:42 PM

Originally Posted by lightwaytbaby

That baby would kick your ass and you know it!

true...

**lightwaytbaby** · 08-01-2007, 12:28 AM

lol...

**auslifta** · 08-01-2007, 01:32 AM

Originally Posted by Devils Mentor

Muscle wasting also is common in the elderly and patients with diseases such as cancer and AIDS.

Some researchers are trying to turn off the myostatin gene in chickens to produce more meat per bird. And several breeds of cattle have natural variations in the gene that, aided by selective breeding, give them far more muscle and less fat than other steer.

DM

mmmmmmmmm decca and tren come to mind. i hope something good comes from this especially something the help kids with muscular dystriphy