Does pain relivers affect muscle building.

**gst528i** · 10-13-2008, 08:23 PM

Just something that poped in my head. I am sore and never take pain relivers weather im sick or wait unless i really even need prescribed medicine.

So question is can you workout harder with pain relivers the next day so you can carry on working out and going about your day after gym days.

if yes than would it affect your end result of muscle growth.

**IronReload04** · 10-13-2008, 08:32 PM

the rumor is that either tylenol or advil, cant remember which one but I think it is advil, can **** with tRNA I think which can I interfere with muscle growth

I am not really sure how true that is, but that is the rumor. Its something i should know being a bios major, but i never really looked into it.

**Amorphic** · 10-13-2008, 08:45 PM

Originally Posted by IronReload04

the rumor is that either tylenol or advil, cant remember which one but I think it is advil, can **** with tRNA I think which can I interfere with muscle growth

I am not really sure how true that is, but that is the rumor. Its something i should know being a bios major, but i never really looked into it.

ive heard this as well but i dont know if its rumor or in fact confirmed. i usually never use painkillers

**Dizz28** · 10-13-2008, 09:01 PM

i've posted this a few times on here...

Motrin and other NSAIDs have an influence on protien synthesis after exercise, in other words - yes it can effect your gains

"Neither drug had any influence on whole body protein breakdown, as
measured by rate of phenylalanine appearance, on serum
creatine kinase, or on rating of perceived muscle soreness
compared with PLA. These results suggest that over-thecounter
doses of both ibuprofen and acetaminophen suppress
the protein synthesis response in skeletal muscle after eccentric
resistance exercise

Ibuprofen and acetaminophen are purported to relieve
muscle soreness and pain through separate mechanisms.
Ibuprofen is known to block cyclooxgenase (EC
1.14.99.1), which then reduces metabolites produced by
this enzyme, such as prostaglandins, that are at least
partially responsible for inflammation and algesia (14,
35, 36). However, prostaglandins have also been shown
to regulate protein metabolism, and NSAIDs similar to
ibuprofen have been shown to blunt protein metabolism
in animal skeletal muscle (24, 30). Therefore,
skeletal muscle protein metabolism may be influenced
in individuals who consume ibuprofen after unaccustomed
exercise. The mechanism of analgesic action of
acetaminophen, also known as paracetamol, is less
clear; however, it is believed to have its analgesic
action within the central nervous system (8, 11, 15, 32,
36). Thus acetaminophen would not be expected to
interfere with muscle protein metabolism after exercise.

......However, long-term use of
these drugs may inhibit the normal hypertrophic response
to resistance training. Future studies on the
impact of chronic consumption of over-the-counter
doses of these drugs on skeletal muscle are warranted"

**Jenseno9** · 10-13-2008, 09:06 PM

no shit heh

**novastepp** · 10-13-2008, 09:20 PM

exactly, some can effect protein synthesis. However, I haven't received a good response on amounts. I once was referenced to an article explaining negative correlations of 3g a day use. which is doctor prescribed amounts, not OTC use.

**stpete** · 10-13-2008, 09:53 PM

I use painkillers. I just keep it to a mimimum. Everything in moderation man.

**Angel of death** · 10-13-2008, 09:57 PM

I've heard painkillers like vicodin and tylenol are known to put you in a catabolic state

**MuscleScience** · 10-13-2008, 10:03 PM

There are papers that say that nsaids negatively impact muscle growth because of the chronic retardation of the inflammatory process essential for muscle repair.

Other papers show no impact positive or negative

While others show that there is a positive effect on muscle growth. The latest paper that I have seen on the subject showed that large prolonged doses of acetaminophen (tylenol) caused an statistically significant increase in muscle growth in conjunction with resistance training vs control groups.

Then again i would rather not take Tylenol for prolonged periods since acetaminophen kill close to 8000 people a year and injures close to 20,000.

**novastepp** · 10-13-2008, 10:15 PM

Originally Posted by Angel of death

I've heard painkillers like vicodin and tylenol are known to put you in a catabolic state

if you're talking about catabolic to fat tissue, sign me up.

i hate that word.

**Nicotine** · 10-13-2008, 11:25 PM

i heard it about Ibuprofin (advil) - that it can be catabolic to muscle tissue and hinder protein synth......

truth tho? dunno.

**gst528i** · 10-14-2008, 12:11 AM

Intresting. So than i take it most people that workout stay away from it.
Well good to know coz i was just gonna pop 2 a day and workout harder. Geuss i'll just have to stay with the pain.
Thanks for the info..

**Nicotine** · 10-14-2008, 12:19 AM

embrace the pain.

i like it, lets me know im hitting it. you'll learn to love it eventually.

**Dizz28** · 10-14-2008, 07:51 AM

Originally Posted by Angel of death

I've heard painkillers like vicodin and tylenol are known to put you in a catabolic state

Because it doesn't, that study clearly states that: " Thus acetaminophen would not be expected to interfere with muscle protein metabolism after exercise."

Tylenol and Ibuprofen are two didfferent things

Originally Posted by Nicotine

i heard it about Ibuprofin (advil) - that it can be catabolic to muscle tissue and hinder protein synth......

truth tho? dunno.

Did you read my previous post at all....

**Johny-too-small** · 10-14-2008, 08:12 AM

If youre on anabolics...and Id assume everyone here is...then dont worry about it. If youre a chronic user of NSAIDS off cycle too...then you might have some hindered growth.

**gst528i** · 10-14-2008, 11:54 AM

^^^ Nah still not on them. Waiting for perhaps another year.

**Angel of death** · 10-14-2008, 02:14 PM

Ok, I was saying what I've heard. Maybe it's wrong...

**40plusnewbie** · 10-14-2008, 04:43 PM

Pain killers that require a prescription like percocet, etc drop testosterone levels .

**KatsMeow** · 10-14-2008, 05:32 PM

my trainer used to take asprin before his workouts...his bodybuilding coach told him to, I can't really remember why I think because it thins the blood and allows more oxygen to get to the muscles. He is a natty BBer and takes a ton of supps all day long, I don't know if there is any truth in it but it seemed to work for him.

**thegodfather** · 10-14-2008, 07:36 PM

Originally Posted by KatsMeow

my trainer used to take asprin before his workouts...his bodybuilding coach told him to, I can't really remember why I think because it thins the blood and allows more oxygen to get to the muscles. He is a natty BBer and takes a ton of supps all day long, I don't know if there is any truth in it but it seemed to work for him.

I took Aspirin once......ONCE...and then I couldn't eat for 2 weeks...That shit is nasty if you're allergic to it.

This topic has been debated before. I would avoid continued use of just about any exogenous substance other than food and vitamins. Continued use of NSAIDs, as stated previously by MS, causes many deaths due to renal failure. It is also possible to overdose on NSAIDs and induce renal failure or liver failure.