Dopamine Deficiency / easily borred / demotivated?

**hammerheart** · 08-13-2016, 06:22 AM

Who doesn't feel amazing on modafinil... nope those works in a totally different manner. Piracetam is an actual drug while alpha-GPC is a precursor for ACh, so it's a "natural" option. It's effective since it's lipophilic and can cross the BBB readily.

Nicotine for example also acts as a ACh agonist.

**marcus300** · 08-19-2016, 07:18 AM

Originally Posted by bizzarro

Who doesn't feel amazing on modafinil... nope those works in a totally different manner. Piracetam is an actual drug while alpha-GPC is a precursor for ACh, so it's a "natural" option. It's effective since it's lipophilic and can cross the BBB readily.

Nicotine for example also acts as a ACh agonist.

I didn't feel anything on modifinil but I've had great feedback from others think it's amazing

**hammerheart** · 08-19-2016, 07:29 AM

Originally Posted by marcus300

I didn't feel anything on modifinil but I've had great feedback from others think it's amazing

Well there are some genotypes that won't respond to modafinil due to polymorphysm in the enzymes that catabolize neurotransmitters.

If that is your case, it means you already have more DA than you need.

**marcus300** · 08-19-2016, 07:32 AM

Originally Posted by bizzarro

Well there are some genotypes that won't respond to modafinil due to polymorphysm in the enzymes that catabolize neurotransmitters.

If that is your case, it means you already have more DA than you need.

Interesting and good to know.

**almostgone** · 08-19-2016, 07:46 AM

Originally Posted by bizzarro

Who doesn't feel amazing on modafinil... nope those works in a totally different manner. Piracetam is an actual drug while alpha-GPC is a precursor for ACh, so it's a "natural" option. It's effective since it's lipophilic and can cross the BBB readily.

Nicotine for example also acts as a ACh agonist.

I like modafanil/armodafanil but have to limit it to an occasional use as it has an effect on my BP, which may be related to prior cardiac events or perhaps from CNS stimulation. I'm a night shift worker, so it can be a huge help. However, it also to tends to affect my sleep so the occasional 100mg is plenty for me.