Anybody know Pinnacle? Or Bill Roberts Personally?

**marcus300** · 10-09-2006, 01:11 AM

If you cant gain on any type of AAS or even respond then i think its time to stop trying, i really don't think your going to get an answer because you have tried and it looks like a few people are getting bored with your problem, id seek a doctors help because i don't think any user will have the answer for you and to be truthful if you cant gain with AAS/training and diet i would just forget about the AAS and concentrate on being natural,

You have asked many times and your still don't have an answer to why you don't respond so id give up and seek advice with a doctor,

I'am sure if you posted your diet and training program the answer would be around them areas IMHO

**Warrior21** · 10-09-2006, 07:26 AM

This weekend I sent out over 40 emails to different doctors specializing in endocrinology. Given that it was weekend, no one responded. I did however get 2 replies this morning. One guy says he wants nothing to do with anabolics.
The other guy who wrote an article on increasing steroid -mediated gene transcription suggested I use the treatment he wrote in his acrticle. He also hinted that I may have an androgen receptor mutation. But this must mean then that synthetic testosterone binds to a different androgen receptor than natural test. Because I don't gain on synthetic test, so if that were the case it would make sense. Otherwise the answer lies in lack of recruitment of coactivators, or too much histone deacetylation.

**stupidhippo** · 10-09-2006, 08:56 AM

what kind of treatment he suggested?

**Warrior21** · 10-09-2006, 11:41 AM

Originally Posted by stupidhippo

what kind of treatment he suggested?

Large doses of Tamoxifen citrate, and a histone deactylase inhibitor. Histone deacetylators reduce gene transcription in muscle tissue. Basically getting the steroids to work is all about activating gene transcription. Theres tons of stuff that activate, and tons of stuff that deactivate gene transcription. Its up to me and the help of some endos to figure it out.

**Swifto** · 10-09-2006, 12:15 PM

I recall Anthony Roberts stating Vit-B6 greatly reduces gene transcription in muscle tissue. May want to adjust your diet or vitamin intake accordingly.

**stupidhippo** · 10-09-2006, 12:17 PM

Originally Posted by Warrior21

Large doses of Tamoxifen citrate, and a histone deactylase inhibitor. Histone deacetylators reduce gene transcription in muscle tissue. Basically getting the steroids to work is all about activating gene transcription. Theres tons of stuff that activate, and tons of stuff that deactivate gene transcription. Its up to me and the help of some endos to figure it out.

ive heard many ppl argue nolva on cycle reduces gains... good luck in ur quest.. btw wherea re ur pics? i must have missed them..

**Warrior21** · 10-09-2006, 12:19 PM

Originally Posted by stupidhippo

ive heard many ppl argue nolva on cycle reduces gains... good luck in ur quest.. btw wherea re ur pics? i must have missed them..

I have a thread called "O/T Warrior21's pics!". It should be on first or second page.

**Warrior21** · 10-09-2006, 12:21 PM

Originally Posted by Swifto

I recall Anthony Roberts stating Vit-B6 greatly reduces gene transcription in muscle tissue. May want to adjust your diet or vitamin intake accordingly.

I'll definately look into this. I'm glad I'm getting some responses besides the traditional, "Your diet and training is the key" answers.

We all know it's not normal to gain 2-5 lbs on an 8 week cycle despite eating 5-6000 cals and training like theres no tommorow.

**Warrior21** · 10-09-2006, 12:24 PM

Originally Posted by Swifto

I recall Anthony Roberts stating Vit-B6 greatly reduces gene transcription in muscle tissue. May want to adjust your diet or vitamin intake accordingly.

Yep he's right. You learn something new everyday. I actually take mutlivitamin 2-3x daily for good luck. I better check out my diet to see which foods are big on B-6. Thanks Swifto. Heres a study showing so;

Modulation of steroid receptor-mediated gene expression by vitamin B6.

Tully DB, Allgood VE, Cidlowski JA.

Department of Physiology, University of North Carolina at Chapel Hill 27599-7545.

Gene transcription mediated by steroid hormones has become one of the most extensively characterized model systems for studying the regulation of gene expression in eukaryotic cells. However, specific details of gene regulation by steroid hormones are often complex and may be unique in specific cell types. Diverse regulatory mechanisms leading to either activation or repression of particular genes frequently involve interactions between steroid hormone receptors and other ubiquitous and/or cell-specific transcription factors that act on the complex promoter of the regulated gene. Interplay between steroid receptor-mediated and other signal transduction pathways may also be involved. In addition, recent novel results indicate that moderate variations in the intracellular concentration of pyridoxal 5'-phosphate (PLP), the biologically active form of vitamin B6, can have pronounced modulatory effects on steroid-induced gene expression. Specifically, elevation of intracellular PLP levels leads to decreased transcriptional responses to glucocorticoid, progesterone, androgen, or estrogen hormones. Conversely, cells in a vitamin B6-deficient state exhibit enhanced responsiveness to steroid hormones. One aspect of the mechanism by which these transcriptional modulatory effects of PLP occur has recently been shown to involve interruption of functional interactions between steroid hormone receptors and the nuclear transcription factor NF1. These findings--that the vitamin B6 nutritional status of cells modulates their capacity to respond to steroid hormones--impose an additional level of cell-specific control over steroid hormone regulation of gene expression and will serve as the focal point for this review.