Ibuprofen’s effect on protein synthesis

**M302_Imola** · 03-06-2008, 08:43 AM

I don’t make a regular practice out of consuming Ibuprofen on a daily basis but here lately my lower back has been giving me some problems, mostly associated with the common pain common with d-bol. I have heard that Ibuprofen slows down protein synthesis, which is obviously not good for us body builders, but will popping a few of these before a workout, maybe three times a week slow down protein synthesis that dramatically?

**kick6** · 03-06-2008, 10:12 AM

Why not use aspirin instead?

**M302_Imola** · 03-06-2008, 10:24 AM

Originally Posted by kick6

Why not use aspirin instead?

I use Ibuprofen for its anti-inflammatory properties, I wasn't aware that aspirin was an anti-inflammatory.

**Bigmax** · 03-06-2008, 10:45 AM

I seriously dont think taking ibuprofen will hinder growth bro...i mean I know countless BBers and other athletes that live on it...I take them when My joints are flared too...remember Tom Prince???..he was HUGE and and lived on them I mean it was reported that he took 12-15 at a a time...they did end his career when he devolped Kidney problemss..point being maybe they do slow down synthesis but not enuff to hurt your growth.

**Dizz28** · 03-06-2008, 11:37 AM

I've posted this study a few times on here. All you had to do was a search for Ibuprofen...

Motrin and other NSAIDs have an influence on protien synthesis after exercise, in other words - yes it can effect your gains

"Neither drug had any influence on whole body protein breakdown, as
measured by rate of phenylalanine appearance, on serum
creatine kinase, or on rating of perceived muscle soreness
compared with PLA. These results suggest that over-thecounter
doses of both ibuprofen and acetaminophen suppress
the protein synthesis response in skeletal muscle after eccentric
resistance exercise

Ibuprofen and acetaminophen are purported to relieve
muscle soreness and pain through separate mechanisms.
Ibuprofen is known to block cyclooxgenase (EC
1.14.99.1), which then reduces metabolites produced by
this enzyme, such as prostaglandins, that are at least
partially responsible for inflammation and algesia (14,
35, 36). However, prostaglandins have also been shown
to regulate protein metabolism, and NSAIDs similar to
ibuprofen have been shown to blunt protein metabolism
in animal skeletal muscle (24, 30). Therefore,
skeletal muscle protein metabolism may be influenced
in individuals who consume ibuprofen after unaccustomed
exercise. The mechanism of analgesic action of
acetaminophen, also known as paracetamol, is less
clear; however, it is believed to have its analgesic
action within the central nervous system (8, 11, 15, 32,
36). Thus acetaminophen would not be expected to
interfere with muscle protein metabolism after exercise.

......However, long-term use of
these drugs may inhibit the normal hypertrophic response
to resistance training. Future studies on the
impact of chronic consumption of over-the-counter
doses of these drugs on skeletal muscle are warranted"

PT · 03-06-2008, 11:39 AM

i think i read that same articel before. i guess it may not of been the same but it stated the same things

**Kratos** · 03-06-2008, 11:44 AM

Taking them everyday can lead to stomach ulcers. I know a girl who took way too may around that time of the month, then she started shitting coffee grinds and lost so much blood to her stomach she needed blood transfusions.

**mick86** · 03-06-2008, 12:00 PM

Originally Posted by Kratos

Taking them everyday can lead to stomach ulcers. I know a girl who took way too may around that time of the month, then she started shitting coffee grinds and lost so much blood to her stomach she needed blood transfusions.

Thats awfell

**M302_Imola** · 03-06-2008, 01:17 PM

Thanks for the feedback guys, I guess I am only going to take it I have to. I mean if the pain is so unbearable that it hinders my workout. Def. wouldn't take 12-15 I guess like most other things, moderation is the key.

**mick86** · 03-06-2008, 01:25 PM

I take tablets containing proxen for inflamatory problems, there great but prescription only. you could always try something else besides ibuprofen to help with the problem. Alternate between a few meds so as not to over use any individual. Just a thought.

**M302_Imola** · 03-07-2008, 08:48 AM

Originally Posted by mick86

I take tablets containing proxen for inflamatory problems, there great but prescription only. you could always try something else besides ibuprofen to help with the problem. Alternate between a few meds so as not to over use any individual. Just a thought.

sounds good bro, I will give it a try

**im83931** · 03-07-2008, 10:35 AM

naproxen and ibuprofen are both nsaids. I would use Ibuprofen. I used to run marathons and we called it vitamin I. The thing about ibuprofen is that it builds up in your system and works better after a couple of doses.
You should also remember that nsaids were designed to be theraputic and not just for an occasional dose. If you have inflamation in one of your joints then 3-4 doses can reduce the inflamation to such a degree that the body can heal itself and you wont get tendonitus.
And yes aspirin has anit-inflamatory properties. You can also use ice packs and drink more water.

20 minutes ice followed by 10 minutes heat can help too.
Ice reduces swelling and inflamation by vasoconstriction
Heat will cause blood to flow more readily to a site it is applied to by vasodilation.

**Lemonada8** · 03-07-2008, 10:55 AM

These results suggest that over-thecounter
doses of both ibuprofen and acetaminophen suppress
the protein synthesis response in skeletal muscle after eccentric
resistance exercise

eccentric resistance... aka negative reps, true you do get more of a work out doing these kinds of reps but if you primarily concentrate on concentric (shorting of muscles), what happens then? i didnt see anything about it... and i'd bet that if you take a minimal dosage that it wouldnt effect it much...

**M302_Imola** · 03-08-2008, 11:27 AM

Originally Posted by im83931

naproxen and ibuprofen are both nsaids. I would use Ibuprofen. I used to run marathons and we called it vitamin I. The thing about ibuprofen is that it builds up in your system and works better after a couple of doses.
You should also remember that nsaids were designed to be theraputic and not just for an occasional dose. If you have inflamation in one of your joints then 3-4 doses can reduce the inflamation to such a degree that the body can heal itself and you wont get tendonitus.
And yes aspirin has anit-inflamatory properties. You can also use ice packs and drink more water.

20 minutes ice followed by 10 minutes heat can help too.
Ice reduces swelling and inflamation by vasoconstriction
Heat will cause blood to flow more readily to a site it is applied to by vasodilation.

great info, thanks