lowering prolactin levels to increase sex drive

[operationgetbig]

I've used 19-nor's in a lot of my cycles and know that they'll increase your prolactin levels alot which will reduce sexual function. right now im running this cycle:

wk1-10:100mg/ed test prop
wk1-8: 75mg/ed tren ace
week5-10: 50mg/ed winny

even tho im taking a high dose of testosterone my sex drive still seems kinda weak considering the dose im taking. I just got on high bp meds because my blood pressure spiked. I've read that high bp can give u erectile dysfunction. I'm hoping after a couple weeks on the meds my sex drive will come back. I was given a calcium channel blocker which is a high bp med least likely to have ED as a side effect. If my sex drive doesnt come back to normal I think it is my prolactin level affecting it. what is good at lowering prolactin?

ive read that b-6 will help and bromo. but what doses? any words of advice.

[peachfuzz]

The How To Use Caber Thread

[johnnybigguns]

Caber is a good start

[peachfuzz]

i already said that :

[Hephens]

I'm on tren now and when i first started off i felt shutdown straight away than a few weeks later i notice my sex drive went up heaps because of the test but also the tren, i feel more horny on tren than test lol.

[operationgetbig]

Caber is a good start

any opinions on bromo? i can get my hands on really cheap human grade bromo.

[Ernst]

B6 does reduce prolactin, but is not nearly as effective as bromo or caber. Anecdotal evidence suggests that bromo comes with more negative sides when used in this capacity. I read up on them both a lot when I was faced with the same decision. I went with research caber and hg bromo as backup just in case since I could also get it cheap. I don't know about you, but I feel weird relying on research chems. Still, the caber has done the trick, and with no negative sides that I've noticed. The bromo sits safely at the bottom of my bag of tricks.

[operationgetbig]

B6 does reduce prolactin, but is not nearly as effective as bromo or caber. Anecdotal evidence suggests that bromo comes with more negative sides when used in this capacity. I read up on them both a lot when I was faced with the same decision. I went with research caber and hg bromo as backup just in case since I could also get it cheap. I don't know about you, but I feel weird relying on research chems. Still, the caber has done the trick, and with no negative sides that I've noticed. The bromo sits safely at the bottom of my bag of tricks.

yeah after researching this stuff i ended up ordering caber from a research chem site. normally i only use human grade stuff but this stuff is just too expensive to order and i need it quick so it's being shipped domestically from a research company. i think im gonna run .5mg twice a week. hopefully this will help me out. deca dick and tren dick is not pleasant especially if u bang chicks on a regular basis. i got some viagra on hand so hopefully that will get me through things till the caber comes.

[spywizard]

sexual desire (libedo)
and
ED are 2 different things..

ED from high bp is treated one way...

sexual desire from too much prolactin is another..
seems like you are suffering from both.

[jimmyinkedup]

It would appear that caber from a research chem site isnt the best idea due to its instability suspended in a liquid. Just an FYI

[Swifto]

Again, there is NO evidence 19-Nor's increase prolactin, or progesterone. Infact, studies in primates state PgR is lowered.

You shouldnt lose your sex drive if you use a form of testosterone .

Use a powerful AI and you shouldnt have problems with gyno when using 19-Nor's.

[Swifto]

B6 does reduce prolactin, but is not nearly as effective as bromo or caber. Anecdotal evidence suggests that bromo comes with more negative sides when used in this capacity. I read up on them both a lot when I was faced with the same decision. I went with research caber and hg bromo as backup just in case since I could also get it cheap. I don't know about you, but I feel weird relying on research chems. Still, the caber has done the trick, and with no negative sides that I've noticed. The bromo sits safely at the bottom of my bag of tricks.

Vit B6 reduces PgR (progesterone), not PRL (prolactin).

It also reduces steroid gene-transcription and isnt a good idea IMHO when wanting to reduce PgR.

[Swifto]

It would appear that caber from a research chem site isnt the best idea due to its instability suspended in a liquid. Just an FYI

Exaclty right.

You need to use legit pharma. grade compounds here.

Same with T3 IMHO.

[Merc.]

Hi Swifto ( sup man ) I couldn't find it but you had posted a very valid study about high dose b-6 causing brain damage( I think it was brain damage not positive ) ....

It was a long time ago and I had it forever , but I can find it now .. Do you remember that one ??


Merc.

[Swifto]

Hi Swifto ( sup man ) I couldn't find it but you had posted a very valid study about high dose b-6 causing brain damage( I think it was brain damage not positive ) ....

It was a long time ago and I had it forever , but I can find it now .. Do you remember that one ??


Merc.

I do, I'll have a look.

I dont remember if it was brain damage or CNS damage...

Either way, I remember.

[Merc.]

Also fellas keep in mind that ALL steroids increase prolactin ( and can decrease sex drive)..


AAS lower t-3 which in turn increases prolactin ...


Merc.

[Merc.]

I do, I'll have a look.

I dont remember if it was brain damage or CNS damage...

Either way, I remember.

AHHH.. I think you are right .. It was CNS damage ... Good shot mate .... Great memory man ..



Merc.

[Swifto]

AHHH.. I think you are right .. It was CNS damage ... Good shot mate .... Great memory man ..



Merc.

Just looked but cant find it.

It was neuropathy. I think it was doses over 200-250mg/ED.

[Swifto]

Also fellas keep in mind that ALL steroids increase prolactin ( and can decrease sex drive)..

AAS lower t-3 which in turn increases prolactin ...


Merc.

Tell me why you think this Merc?

[Ernst]

Swifto, if you don't mind I'd love a PM of the article or source of that info. I have found numerous articles from good sources supporting the argument that b6 lowers prolactin. I only recall one instance where pgr was mentioned and it actually was raised (but this was in pregnant women so... take that with a grain of salt).




Suppression of pimozide-induced prolactin secretion by piridoxine (vitamin B6).

Full Abstract
I.V. administration of 300 mg. Pyridoxine caused an acute fall in prolactin (PRL) plasma levels in six normal subjects. Like levodopa, pyridoxine suppressed the increase in PRL secretion induced by treatment with pimozide, a specific dopamine receptor blocking agent. These findings further support the hypothesis that vitamin B6 stimulates dopaminergic activity at hypothalamic and/or hypophyseal level.

Author information
Author/s: Delitala, G (G); Masala, A (A); Alagna, S (S);

Journal and publication information
Publication Type: Journal Article

Journal: Biomedicine / [publiée pour l'A.A.I.C.I.G.] (Biomedicine), published in FRANCE. (Language: eng)

Reference: 1977-Jul; vol 27 (issue 5) : pp 191-2

Dates: Created 1978/01/27; Completed 1978/01/27; Revised 2004/11/17;

PMID: 562688, status: MEDLINE (last retrieval date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

[Swifto]

Swifto, if you don't mind I'd love a PM of the article or source of that info. I have found numerous articles from good sources supporting the argument that b6 lowers prolactin. I only recall one instance where pgr was mentioned and it actually was raised (but this was in pregnant women so... take that with a grain of salt).




Suppression of pimozide-induced prolactin secretion by piridoxine (vitamin B6).

Full Abstract
I.V. administration of 300 mg. Pyridoxine caused an acute fall in prolactin (PRL) plasma levels in six normal subjects. Like levodopa, pyridoxine suppressed the increase in PRL secretion induced by treatment with pimozide, a specific dopamine receptor blocking agent. These findings further support the hypothesis that vitamin B6 stimulates dopaminergic activity at hypothalamic and/or hypophyseal level.

Author information
Author/s: Delitala, G (G); Masala, A (A); Alagna, S (S);

Journal and publication information
Publication Type: Journal Article

Journal: Biomedicine / [publiée pour l'A.A.I.C.I.G.] (Biomedicine), published in FRANCE. (Language: eng)

Reference: 1977-Jul; vol 27 (issue 5) : pp 191-2

Dates: Created 1978/01/27; Completed 1978/01/27; Revised 2004/11/17;

PMID: 562688, status: MEDLINE (last retrieval date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

I've never seen that study before, I've learnt something today, thank-you.

Was this study on males or females?

Although this study states PRL was lowered, b6 is detrimental to ones cycle in more ways than one. When one starts to exceed 200-250mg/ED nueropathy begins to occur and you can ruduce androgen gene-transcription by about 35-40%.

[operationgetbig]

It would appear that caber from a research chem site isnt the best idea due to its instability suspended in a liquid. Just an FYI

even if u shake it up real good? Im assuming its kinda like winny where if u let it sit it will settle. i know the dosage wont be as exact as it would if i were to use human grade. but i already ordered it so i'll just see how it goes.

[Phate]

It would appear that caber from a research chem site isnt the best idea due to its instability suspended in a liquid. Just an FYI

Exaclty right.

You need to use legit pharma. grade compounds here.

Same with T3 IMHO.

could you two expand on this? are you referring to molecular instability or solubility issues?

[operationgetbig]

sexual desire (libedo)
and
ED are 2 different things..

ED from high bp is treated one way...

sexual desire from too much prolactin is another..
seems like you are suffering from both.

yeah it does seem like that...well im already a week in on my hp med (amlodipine 10mg/ed). so hopefully my bp will drop back to normal soon if it hasnt already.

and the caber is on it's way so hopefully i can reduce my prolactin to get my libido back.

[Swifto]

could you two expand on this? are you referring to molecular instability or solubility issues?

I'll look into it more. But I've seen it posted numerous times with Caber by some very intelligent members elsewhere.

Thats why I found myself a source of legit pharm. grade caber and T3.

[Merc.]

Tell me why you think this Merc?

I cant find the studies right now .... but Big-K and I were doing some research( like back in 06 I think) and found some solid evidence confirming it ( again as you know research has its place , but it not the end all be all .. you basically can find a study stating anything you want to .. I would say like 50 % of pubmed stuff is inaccurate in some way or the other .( as you know you have to know what your looking for .. true science and research is a skill ) .. But this came from a VERY solid source .. and IMO was very valid at the time ....

Anyways it started with this thread back in 06 ... Whats the real reason?? about the prolactin lower t-3 research thing ).. see Big K post ..



Merc.

[Merc.]

Just looked but cant find it.

It was neuropathy. I think it was doses over 200-250mg/ED.

cooll .. thanks ... It just came to mind when I was reading this thread ...




Merc.

[Phate]

I'll look into it more. But I've seen it posted numerous times with Caber by some very intelligent members elsewhere.

Thats why I found myself a source of legit pharm. grade caber and T3.

i'll look as well, i have sources for pharm grade t3 but research chem is so much cheaper so i've always used it, might have to switch

[Swifto]

I cant find the studies right now .... but Big-K and I were doing some research( like back in 06 I think) and found some solid evidence confirming it ( again as you know research has its place , but it not the end all be all .. you basically can find a study stating anything you want to .. I would say like 50 % of pubmed stuff is inaccurate in some way or the other .( as you know you have to know what your looking for .. true science and research is a skill ) .. But this came from a VERY solid source .. and IMO was very valid at the time ....

Anyways it started with this thread back in 06 ... Whats the real reason?? about the prolactin lower t-3 research thing ).. see Big K post ..



Merc.

Thats just BigK stating a decrease in T3 causes an increase in PRL. There is no evidence.

I've been looking at this for a while now and have come up with nothing to state andorgens increase PRL, at all. Infact, a member over at CEM (Oswaldo) got BW done on Deca alone ramping to 800m/wk with no increase in PRL, only a slight increase in E.

[DSM4Life]

Go check out the homo goodness thread, that might help

[operationgetbig]

i found this on the research chem site i ordered my caber from

Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.

the caber they sell is an aqueous solution. so this means that their product will settle at the bottom. will shaking the solution up before you draw it be good enough to mix the solution to get a dose accurate enough.

[Merc.]

Thats just BigK stating a decrease in T3 causes an increase in PRL. There is no evidence.

I've been looking at this for a while now and have come up with nothing to state andorgens increase PRL, at all. Infact, a member over at CEM (Oswaldo) got BW done on Deca alone ramping to 800m/wk with no increase in PRL, only a slight increase in E.

NO NO my bad man .. I was just stating thats what started the AAS increasing prolactin thing .. which lead to further research .. my bad for the mis -understanding on that ... I cant find the exact paper I am referring to right now ... I am not sure if it was something that was online of if we had to actually go to the university to get it ....

Thats interesting about Oswaldo .. Defiantly a very interesting topic to further look into ..

In the case of no peer reviewed journals I have been taught that the best way to determine research quality is generally considered to assess impact factor AND check the credibility of the institution that published the data.

At least 50% of studies available at Pubmed are pretty much worthless although impact factor may be an imperfect design I've been taught that its much better than trusting sales articles or random hits at Pubmed to help determine if something is correct or not . Just saying in general ....

This is a good topic IMO ..

Merc.

[Merc.]

Go check out the homo goodness thread, that might help

sup DSM

[Merc.]

For those interested in impact factor you can check this if you would like to ...

http://en.wikipedia.org/wiki/Impact_Factor just including this because i mentioned it in my above post .....



Merc.

[Swifto]

NO NO my bad man .. I was just stating thats what started the AAS increasing prolactin thing .. which lead to further research .. my bad for the mis -understanding on that ... I cant find the exact paper I am referring to right now ... I am not sure if it was something that was online of if we had to actually go to the university to get it ....

Thats interesting about Oswaldo .. Defiantly a very interesting topic to further look into ..

In the case of no peer reviewed journals I have been taught that the best way to determine research quality is generally considered to assess impact factor AND check the credibility of the institution that published the data.

At least 50% of studies available at Pubmed are pretty much worthless although impact factor may be an imperfect design I've been taught that its much better than trusting sales articles or random hits at Pubmed to help determine if something is correct or not . Just saying in general ....

This is a good topic IMO ..

Merc.

I agree, its a great topic and I dont think anyone has a difinitive correct answer yet. Were debating things that arnt fully understood here IMHO.

I also agree that there is usually a contradicting study somewhere, but there is, so far, no evidence on pubmed, stating Deca (Nandrolone ) or Trenbolone difinitively increase PRL to my knowledge. Thats why I'm always intrested in users BW on these compounds.

Good topic.

[Merc.]

I agree, its a great topic and I dont think anyone has a difinitive correct answer yet. Were debating things that arnt fully understood here IMHO.

I also agree that there is usually a contradicting study somewhere, but there is, so far, no evidence on pubmed, stating Deca (Nandrolone ) or Trenbolone difinitively increase PRL to my knowledge. Thats why I'm always intrested in users BW on these compounds.

Good topic.

Totally agree mate..

So I retract my statement , or shall I say instead ... it is possible that ALL AAS lower t-3 which in turn could increase prolactin levels ... or something to that effect ... hehehehhee




Merc.

[Phate]

i found this on the research chem site i ordered my caber from

Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.

the caber they sell is an aqueous solution. so this means that their product will settle at the bottom. will shaking the solution up before you draw it be good enough to mix the solution to get a dose accurate enough.

i know the source you are talking about, what you could do if you wanted is this

take the caber they give you, which should be 0.5mg/mL, get another bottle and add 30mL of everclear(which is 95% ethyl alcohol, or you can convert it to 100%, i'll provide a thread to do this)

this will give you a solution of 60mL with 15mg of caber, or 0.25mg/mL, ethyl alcohol and water are infinitely soluable in each other, and the caber will bond with the ethyl alcohol, which in turn bonds via polar bonds to the water

now you have a completely soluble solution, at least in theory


everclear to ethanol
http://forums.steroid.com/showthread.php?t=171159

[operationgetbig]

i know the source you are talking about, what you could do if you wanted is this

take the caber they give you, which should be 0.5mg/mL, get another bottle and add 30mL of everclear(which is 95% ethyl alcohol, or you can convert it to 100%, i'll provide a thread to do this)

this will give you a solution of 60mL with 15mg of caber, or 0.25mg/mL, ethyl alcohol and water are infinitely soluable in each other, and the caber will bond with the ethyl alcohol, which in turn bonds via polar bonds to the water

now you have a completely soluble solution, at least in theory


everclear to ethanol
http://forums.steroid.com/showthread.php?t=171159

i ended up emailing the company asking to cancel my order. im going to go with human grade caber instead. i'll just have to wait a lil longer cause it's gonna be shipped internationally.

[jimmyinkedup]

could you two expand on this? are you referring to molecular instability or solubility issues?

caber is crystaline in structure...in order to create any stability even in aqueous suspension the solution needs to be very alkaline in ph and even them to suggest it would remain stable for over IMO 20-25 days is unlikely. How long do u think its been on the shelves and how long will you store it.
To tell you the truth even dissolving in ethanol would imo not reduce instability one bit...in fact of all things to try dissolve it in that MAY and i say MAY work it would be mct oil...but then you would need caber powder. (unless you have access to fluoroalkyl hydrocarbons - which im sure is not an option)

[peachfuzz]

^Nerds