Active-life vs. Half-life question..

[ythrashin]

I posted this question here in the educational thread but not many people check it so I'm posting it here...

Understanding Esters, Active-Life and Half-Life


I wondering about this part in the article...

Active Life versus Half Life

The confusion comes from the 2 terms being used synonymously when they should not be. "Half-life is not a reference for the total time a drug will be found active in the body. It may take several half-lives before the drug is completely inactive."

Half-life: The period of time required for the concentration or amount of drug in the body to be reduced to exactly one-half of a given concentration or amount.

Example: The half-life of anavar is 9 hours+/- (9 hours after oral administration of 50 mg of anavar, 25mg is still present in the body).

Active life: Refers to the period in which the amount of a drug in the body is enough that it will still produce the desired effects for which it was administered. Or conversely, inhibit natural recovery of normal bodily function. It is dose dependent.

Example: The active life of 1,000mg of testosterone decanoate would be more than one month. At day 30 after injection, 250mg or more of this drug would still be present in the body.

If active-life is dose dependent...

Wouldnt a lot of our protocols on when whe start PCT be wrong?

For example say we are running 800mg of Test C per week.
After 12 days according to this you would still have 400mg active in your body...
So that is obviously to much active Test to start PCT...

So what gives?
I have a vet telling me that this article is wrong on another forum?

Your thoughts?

[Phate]

I posted this question here in the educational thread but not many people check it so I'm posting it here...

Understanding Esters, Active-Life and Half-Life


I wondering about this part in the article...



If active-life is dose dependent...

Wouldnt a lot of our protocols on when whe start PCT be wrong?

For example say we are running 800mg of Test C per week.
After 12 days according to this you would still have 400mg active in your body...
So that is obviously to much active Test to start PCT...

So what gives?
I have a vet telling me that this article is wrong on another forum?

Your thoughts?

the measures we use are kind of "rule of thumb", you could calculate out exactly when to start pct but how would you know what the amount of active test should be? not all active test is free test and the efficiency is not 100% when it's being metabolized

in short, the average starting cycle is 500mg/wk, when you start pct ~250mg will be left if using enth/cyp, this dosage(250mg) is prescribed by doctors for testosterone replacement therapy so it's a good guideline to go by, but you can adjust as needed