Is constant AA levels needed?

[Kärnfysikern]

After the small discussion in the other thread I decided to get my thumb out of my ass and do a search. I found this

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

1. The aim of this study was to describe the time course of the response of human muscle protein synthesis (MPS) to a square wave increase in availability of amino acids (AAs) in plasma. We investigated the responses of quadriceps MPS to a approximately 1.7-fold increase in plasma AA concentrations using an intravenous infusion of 162 mg (kg body weight)(-1) h(-1) of mixed AAs. MPS was estimated from D3-leucine labelling in protein after a primed, constant intravenous infusion of D3-ketoisocaproate, increased appropriately during AA infusion. 2. Muscle was separated into myofibrillar, sarcoplasmic and mitochondrial fractions. MPS, both of mixed muscle and of fractions, was estimated during a basal period (2.5 h) and at 0.5-4 h intervals for 6 h of AA infusion. 3. Rates of mixed MPS were not significantly different from basal (0.076 +/- 0.008 % h(-1)) in the first 0.5 h of AA infusion but then rose rapidly to a peak after 2 h of approximately 2.8 times the basal value. Thereafter, rates declined rapidly to the basal value. All muscle fractions showed a similar pattern. 4. The results suggest that MPS responds rapidly to increased availability of AAs but is then inhibited, despite continued AA availability. These results suggest that the fed state accretion of muscle protein may be limited by a metabolic mechanism whenever the requirement for substrate for protein synthesis is exceeded.

[Kärnfysikern]

So that means to me if I interpret it right(might draw the wrong conclusion offcourse) that we dont realy have to sweat having our meals evenly spaced out and always having some protein in us.
The body is limited in how much it will do with the AA we give it so it wont make a difference. A meal every 4 hours seems to do the trick with the figures given above. If we consider only protein synthesis and not the metabolic advantage of more closely spaced meals.

[Kärnfysikern]

What I would want to know is if I have a meal then wait and let protein synthesis drop down to baseline levels again after maby 3-4 hours. Then I have another meal.
Will this second meal also cause a increase in protein synthesis or will it have zero effect because the respons to AA is still blunted by the first meal.

How long must the body be "deprived" of aminoacids for it to responds to them again?

[perfectbeast2001]

interesting stuff, I wish I was intelligent enough to answer your question.

[zodiac666]

interesting stuff, I wish I was intelligent enough to answer your question.

ditto, lol

[Jakspro]

interesting stuff, though i think there are a few confounds in that study. Bump for thoughts