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  1. #41
    ecdysone is offline Knowledgeable Member
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    Safe? You want safe???

    Consider, if you will, that two (HCG , AI) of the three substances we use are definately "off-label."

    And the third, test, is used contrary to the manufactures specifications (every two weeks).

    The way I see it, our chances of survival are dim, at best!

  2. #42
    bass's Avatar
    bass is offline HRT Specialist ~ Knowledgeable Member
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    Quote Originally Posted by gdevine View Post
    To put 1 mg AI daily in perspective; below is from the FDA on AI use in women with diagnosed breast Cancer:

    Anastrozole Dosage and Administration

    Recommended Dose


    The dose of Anastrozole is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Anastrozole should be continued until tumor progression. Anastrozole can be taken with or without food.

    For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial Anastrozole was administered for five years. [see CLINICAL STUDIES (14.1)]

    No dosage adjustment is necessary for patients with renal impairment or for elderly patients. [see USE IN SPECIFIC POPULATIONS (8.6)]

    1 mg per day is a chemotherapeutic dosage in the case above at least.

    I don't think I'd want to take 1 mg of an AI daily for any reason unless of course I had breast cancer
    that is scary!

  3. #43
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    Quote Originally Posted by bass View Post
    that is scary!
    Yes. Puts in perspective how powerful this drug really is b!

  4. #44
    Fred40 is offline Associate Member
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    Quote Originally Posted by ecdysone View Post
    Safe? You want safe???

    Consider, if you will, that two (HCG , AI) of the three substances we use are definately "off-label."

    And the third, test, is used contrary to the manufactures specifications (every two weeks).

    The way I see it, our chances of survival are dim, at best!

    "On a long enough timeline, the survival rate for everyone drops to zero"

  5. #45
    ecdysone is offline Knowledgeable Member
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    Quote Originally Posted by gdevine View Post
    To put 1 mg AI daily in perspective; below is from the FDA on AI use in women with diagnosed breast Cancer:

    Anastrozole Dosage and Administration

    Recommended Dose


    The dose of Anastrozole is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Anastrozole should be continued until tumor progression. Anastrozole can be taken with or without food.

    For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial Anastrozole was administered for five years. [see CLINICAL STUDIES (14.1)]

    No dosage adjustment is necessary for patients with renal impairment or for elderly patients. [see USE IN SPECIFIC POPULATIONS (8.6)]

    1 mg per day is a chemotherapeutic dosage in the case above at least.

    I don't think I'd want to take 1 mg of an AI daily for any reason unless of course I had breast cancer

    Yes, but if you want another perspective on dosing, according to this statement, studies were conducted using 10 mg/day doses with no adverse effects, apparently after 3 years.

    Single doses of 60 mg were tolerated and there was no toxic dose known.

    However, my favor warning is: the drug should not be taken by men or children!
    Last edited by ecdysone; 12-08-2011 at 12:00 PM.

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