Estradiol and Therapeutic Management: What you should know.

[steroid.com 1]

That chart is a hoot!

Damn, that guy's it too ripped for his age!

I do luv ya bro

[junk2222yard]

Wow, xtitan1, thanks for the writeup. Offhand, I *sort of* understand, but I will re-read it until I get it, and check out the link you have, too. Just wanted to say thanks for taking the time!

...Hope that helps. By the way, I have found that my E2 (regular test) has been very accurate and Shippen does not bother with the ultrasensitive assay, but that's just anecdotal.

Yes, I appreciate the anecdotes! There is much anecdotal evidence that suggests you can get by with a regular E2 tests (there are various methods used in Canada and elsewhere), so I do appreciate your personal experience and mention of Shippen. I will look over my bookmarks related to this and add to this thread. So possibly saying anything but the sensitive assay is "useless" may be overstating things. (Though the original E2 writeup is terrific and much appreciated -- not trying to be a jerk! -- the stickies here are amazing.)

[kelkel]

I knew I was forgetting something...


Attachment 130344

That's hysterical XT!


ps: You calling me "old" GD? If so, say it louder please....

[Moparman]

Ok so I read all this and have some questions. My clinic prescribed me anastazole in 1mg pills and I was instructed to take them twice a week- Monday and thursday.

That seems like a lot compared to what I see others taking. My T is dosed at 200 mg a week and I'm splitting that so 100 mg Friday morn and 100 mg Monday night.

So I'm taking 2 mg of anastazole a week

Is that too much??


Second concerning the regular Estradiol test at Quest labs- I've heard the sensitive test is better because the ranges for the regular test are set for women. Are you sure about this cause the range on my estradiol test is <=39 pg/ML while on my wife's test from the same lab it's a completely different range

For her the ranges are:
Follicular range 19-144
Midcycle range 64-357
Luteal phase 56-214
Post menopausal <=31

So her ranges are definitely geared towards a woman and are different than mine. So is it really a bell curve range issue?

[steroid.com 1]

Ok so I read all this and have some questions. My clinic prescribed me anastazole in 1mg pills and I was instructed to take them twice a week- Monday and thursday.

That seems like a lot compared to what I see others taking. My T is dosed at 200 mg a week and I'm splitting that so 100 mg Friday morn and 100 mg Monday night.

So I'm taking 2 mg of anastazole a week

Is that too much??
Rule of thumb on a start protocol is 1 mg of an AI per 100 mg of Testosterone IM. So, it's about right to be honest and you will need to confirm E2 on 6 weeks labs. If it were me, I'd go with .5 mg 24 hours after each injection and see where you at in 6 weeks (I like the start low and go slow approach). Make sure, either way, to take the AI 24 hours after your injection.


Second concerning the regular Estradiol test at Quest labs- I've heard the sensitive test is better because the ranges for the regular test are set for women. Are you sure about this cause the range on my estradiol test is <=39 pg/ML while on my wife's test from the same lab it's a completely different range.
Absolutely. The standard/default E2 lab is designed for women as explained in this thread. It over estimates a males E2 serum level and hence makes it inaccurate...you could be taking more of an AI than you need otherwise.

For her the ranges are:
Follicular range 19-144
Midcycle range 64-357
Luteal phase 56-214
Post menopausal <=31

So her ranges are definitely geared towards a woman and are different than mine. So is it really a bell curve range issue?
Yes.

Bold.

[Vettester]

Mopar, IMHO, 2mg is way too much for a 200mg protocol, unless you just have a really high rate of conversion of test to E2. We really need the sensitive assay to make a better assessment, but even if your E2 was a bit high, I'd start out with no more than 1mg/wk, then run labs 4 to 6 weeks later to see what adjustments need to be made. Everyone metabolizes differently, but I know 2mg would crash me (been there, it's not fun), or at best take me to the single digits with a 200mg/wk protocol. Just my .02 and food for thought.

BTW, I helped a member here a few years ago who was taking a little more; 2.5mg/wk with a 200mg of test protocol. Not only did it crash him, but he got real sick and was down and out for months!!. His immune system was tanked for a few months, lipids were shot, and his enzymes were elevated. If memory serves correct, he was also developing some thyroid issues at that point, and some various autoimmune disorders were being looked into by his doctors. Just saying, nothing good happens when E2 tanks.

[msmopar]

What happens when u crash?

Is it just being tired? Feeling bad?? Both?

[bethdoth]

After reading all of this post and what others had to say I am concerned. I think I may be taking to much liquid exemestane and crashing my E2. My E2 was 52 on March 6th (see pic with lab results) I s there anyway to tell from this lab result if it was a "Sensitive test"?

The stane is standard 30ml bottle where 25mg/ml. I have been using the 1ml syringe provided that is divided into 10 units. So to the 10th line would be 25mg, the first line would be 2.5mg (25/10= 2.5mg per unit) I have been taking to the 2nd line (2 units) 5mg daily!!! !! So if I was to take .25mg 24 hours after test, how would I do that since just 1/5th of 1 unit ... basically the end of the syringe (green line) is .5mg?

I am leaving for Jamaica Saturday morning and have labs scheduled for the 17th to check everything again. Should I just stop taking an AI while on vacation? I have been feeling a bit fatigued (same as msmopar) but, my libido and joints and all other things are fine.

Please advise! I have an appointment with yet a 5th doctor on the 24th back to Endro after the urologists wouldn't prescribe HCG or an AI.

[jumpingout]

Thanks very much, most helpful.