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Thread: 5 weeks on TRT and still NOTHING....at all

  1. #1
    Remington's Avatar
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    5 weeks on TRT and still NOTHING....at all

    Going into 5 weeks of this and still nothing?
    Started out like this:
    Testosterone , Serum---264 ng/dl
    Estradoil---21.0 pg/ml
    Prostate -Specific Ag--0.5
    Hemoglobin---14.6 g/dl

    New labs show this:
    Estradoil--52.7
    Test--682

    They started me on Anastrazole---so far a week of that.
    Nothing.
    Nothing at all.
    I think I need more Test---but what do I know?

    Any ideas?
    I know when they see the next labs---the TRT clinic I go to is going to say to give it time.
    I understand that...but..come on...I should feel SOMETHING now.

    How do I go about getting more T from the doc?

  2. #2
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    Quote Originally Posted by Remington View Post
    Going into 5 weeks of this and still nothing?
    Started out like this:
    Testosterone , Serum---264 ng/dl
    Estradoil---21.0 pg/ml
    Prostate -Specific Ag--0.5
    Hemoglobin---14.6 g/dl

    New labs show this:
    Estradoil--52.7
    Test--682

    They started me on Anastrazole---so far a week of that.
    Nothing.
    Nothing at all.
    I think I need more Test---but what do I know?

    Any ideas?
    I know when they see the next labs---the TRT clinic I go to is going to say to give it time.
    I understand that...but..come on...I should feel SOMETHING now.

    How do I go about getting more T from the doc?
    is it an anti aging clinic? they are usually money pits and will give you as much test as you want...and they usually believe in high t numbers. Your estrogen went up a lot so maybe that's why you dont feel different. 682 is not the best test number in the world but still where most 20 year olds are close to.

  3. #3
    bass's Avatar
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    how much anastrozole? everyone is different, but generally one will start noticing the effects from 2-8 weeks.

  4. #4
    Remington's Avatar
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    It's a mens Testosterone clinic. I'm taking one half Anastrazole a week.
    I dunno how much they subscribe to that "will give you as much test as you want...and they usually believe in high t numbers". The vibe I'm getting from them is they make small increases and never go above 200 Test /week.
    Which is okay---if it worked.
    I don't want to have to wait 5 MORE weeks for yet another 10mg Test dosage increase.
    I'd prefer to just go right to 200mg next week.

  5. #5
    FRDave's Avatar
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    5 weeks is way too soon. Your blood levels will continue to raise another good 3-5 weeks, and your test levels will also raise once your E2 is in check.

    Patience is the key here, your jumping the gun and it will take you forever to get dialed in if you start making changes. Even people on cycle say they don't usually start feeling the effects till week 6 and they are taking 400mg + per week.

  6. #6
    Remington's Avatar
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    Quote Originally Posted by FRDave View Post
    Even people on cycle say they don't usually start feeling the effects till week 6 and they are taking 400mg + per week.
    Doesn't that contradict the "Stickey" here where it says generally 3 weeks SOME effects start to appear??
    Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
    Changes in erections/ejaculations may require up to 6 months.
    Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
    Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
    First effects on erythropoiesis after 3 months, peaking at 9-12 months.
    Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
    Effects on lipids appear after 4 weeks, maximal after 6-12 months.
    Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
    Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
    Effects on inflammation occur within 3 to 12 weeks.
    Effects on bone detectable after 6 months but continue at least for 3 years.


  7. #7
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    Quote Originally Posted by Remington View Post
    It's a mens Testosterone clinic. I'm taking one half Anastrazole a week.
    I dunno how much they subscribe to that "will give you as much test as you want...and they usually believe in high t numbers". The vibe I'm getting from them is they make small increases and never go above 200 Test /week.
    Which is okay---if it worked.
    I don't want to have to wait 5 MORE weeks for yet another 10mg Test dosage increase.
    I'd prefer to just go right to 200mg next week.
    are you doing it sub q? frdave said it takes 9 weeks to reach peak numbers. Either way 6 weeks is usually when most people get bloods so 5 weeks is a little earlier. Not to get into your personal life, but im sure the clinic is charging you a few thousand per year, so if you aren't happy you can find another.

  8. #8
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    Quote Originally Posted by Remington View Post
    Doesn't that contradict the "Stickey" here where it says generally 3 weeks SOME effects start to appear??
    Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
    Changes in erections/ejaculations may require up to 6 months.
    Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
    Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
    First effects on erythropoiesis after 3 months, peaking at 9-12 months.
    Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
    Effects on lipids appear after 4 weeks, maximal after 6-12 months.
    Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
    Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
    Effects on inflammation occur within 3 to 12 weeks.
    Effects on bone detectable after 6 months but continue at least for 3 years.

    all it says is inflammation and sex drive benefits occur. If you have no inflammation that's hard to tell, and you may just be one of the guys who takes longer for libido issues.

    everyone's different, my tt is 339 and my libido is ok and i can get hard.

  9. #9
    FRDave's Avatar
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    Quote Originally Posted by Remington

    Doesn't that contradict the "Stickey" here where it says generally 3 weeks SOME effects start to appear??
    Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.
    Changes in erections/ejaculations may require up to 6 months.
    Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.
    Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.
    First effects on erythropoiesis after 3 months, peaking at 9-12 months.
    Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.
    Effects on lipids appear after 4 weeks, maximal after 6-12 months.
    Insulin sensitivity may improve within few days, but effects on gly***ic control become evident only after 3-12 months.
    Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.
    Effects on inflammation occur within 3 to 12 weeks.
    Effects on bone detectable after 6 months but continue at least for 3 years.

    I felt very little for the first couple months and is seems most will agree regardless of what the sticky states. Until your blood levels are fully saturated and your E2 is dialed in, which it's not, your not going to feel much if at all.

    Give it some time.... I am 6 months in and just finally got my E2 dialed in, which made the biggest difference. I have lost over 10lbs in the last two weeks, libidio has sky rocketed and I have energy like there is no tomorrow. Prior to getting my E2 in check, I felt much better but it was not night and day like it is now :-D
    Last edited by FRDave; 07-16-2013 at 07:44 PM.

  10. #10
    Remington's Avatar
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    FRDave...what did you do specifically to get your E2 in check?

    Oh...and hey thanks a bunch for all the replies everybody.

  11. #11
    johnhenry is offline Junior Member
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    Quote Originally Posted by FRDave View Post
    I felt very little for the first couple months and is seems most will agree regardless of what the sticky states. Until your blood levels are fully saturated and your E2 is dialed in, which it's not, your not going to feel much if at all.

    Give it some time.... I am 6 months in and just finally got my E2 dialed in, which made the biggest difference. I have lost over 10lbs in the last two weeks, libidio has sky rocketed and I have energy like there is no tomorrow. Prior to getting my E2 in check, I felt much better but it was not night and day like it is now :-D
    It's good to be reminded that this needs time - I am about 5 weeks on. There is slight improvement, but going on FRDave's comments I will delay blood testing until week 9 or so. I guess it takes time for the body to reach homeostasis.

  12. #12
    FRDave's Avatar
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    Quote Originally Posted by Remington
    FRDave...what did you do specifically to get your E2 in check?

    Oh...and hey thanks a bunch for all the replies everybody.
    I take .75mg of Arimidex twice a week (1.5mg total), 24hrs after my test injections. This is more than most will need as I seem to aromatize more than the norm :-/

    I started out slowly though... No arimidex at first. I then dropped test dosage from 100mg to 80mg weekly. I then changed up HCG from 400iu twice weekly to 250iu 3x per week. I then tried 150mg zinc daily. Once all of the above failed to lower E2, I added arimidex at .5mg after each injection. Lastly bumping it to .75mg after each injection.

    Being that I change one thing at a time and get follow-up blood work every 6 weeks, it took a good 7 months as of this July and I will not know if I am dialed in for another 4 weeks. I feel great now that I upped the Arimidex so I'm assuming I'm good now... Hopefully.
    Last edited by FRDave; 07-16-2013 at 11:16 PM.
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  13. #13
    HRTstudent's Avatar
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    I never "felt" anything from being on TRT... even after a year now of having youthful testosterone levels .

    It takes time for stereotypes to fade ... but eventually I did look back and say, "Hey... that got better" or "This affliction is gone"... stuff like that.

    But I never woke up one day and said Aha! I'm superman!
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  14. #14
    FRDave's Avatar
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    Quote Originally Posted by johnhenry

    It's good to be reminded that this needs time - I am about 5 weeks on. There is slight improvement, but going on FRDave's comments I will delay blood testing until week 9 or so. I guess it takes time for the body to reach homeostasis.
    My blood levels rose for a good 10 weeks injecting via sub-Q. I believe IM may be a little quicker, but I personally would wait a good 8-10 weeks after the initial start date before making any changes to protocol.

  15. #15
    Remington's Avatar
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    Does anybody else think a 10mg increase is a waste? I mean--I understand the doctors want to give JUST ENOUGH to get you there...and that makes sense to me.
    But 10mg??

    KINDA seems like they're trying to milk me as a customer...giving me just a little at a time.

  16. #16
    FRDave's Avatar
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    Quote Originally Posted by Remington
    Does anybody else think a 10mg increase is a waste? I mean--I understand the doctors want to give JUST ENOUGH to get you there...and that makes sense to me.
    But 10mg??

    KINDA seems like they're trying to milk me as a customer...giving me just a little at a time.
    10mg can make a big difference, depending on the individual. 20mg lowered me a good 200 points (went from 100 to 80mg of test weekly), so I would assume every 10mg is good for ~100 points in my body.

  17. #17
    LowT Mike is offline HRT Specialist, P.A. - LowTestosterone.com
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    You need to watch the E2. Your E2 is competing for test and High E2 has the same symptoms of andropause and can mask the underlying issue. get the E2 under control. Youll feel better. Anastrozole can give a 20% bump in your T levels as well. Think about it. If you control E2 conversion then it goes along the Testosterone enzematic pathway and not the E2 conversion pathway.

  18. #18
    laser's Avatar
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    Quote Originally Posted by Remington View Post
    Going into 5 weeks of this and still nothing?
    Started out like this:
    Testosterone , Serum---264 ng/dl
    Estradoil---21.0 pg/ml
    Prostate -Specific Ag--0.5
    Hemoglobin---14.6 g/dl



    New labs show this:
    Estradoil--52.7
    Test--682

    They started me on Anastrazole---so far a week of that.
    Nothing.
    Nothing at all.
    I think I need more Test---but what do I know?

    Any ideas?
    I know when they see the next labs---the TRT clinic I go to is going to say to give it time.
    I understand that...but..come on...I should feel SOMETHING now.

    How do I go about getting more T from the doc?
    When the clinic started my treatment they told me they would get me back to my old young self again, so to speak. What did your clinic say to you? During my physical, they noted my Fatigue, muscle loss, etc, etc, etc.
    Everyone is different, like the pro's are saying you may need to give it more time. I was surprised I felt a huge difference with the 1st pin. My energy level is up, sharper vision, reflexes getting better, better appetite, libido is getting better. Do not get me wrong, I was in bad shape for a long time, and T was in the 200 range early morning test, and dropped lower in the afternoon.
    I would give it time like the vets are saying. Although, could be the clinic, and T brand/type. I am still learning as we all are, but if a clinic, or doctor does not listen to the patient, and your not feeling better...later you may think about changing clinics. I am happy with my DOC, and Clinic, I have a problem with the long drive. When I started I did not expect to feel any changes until about 6 weeks. Like I said, I started feeling better the same day. I really wish the best for you, and hope it kicks in soon. I understand.

  19. #19
    Metalject's Avatar
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    Quality therapy isn't just about your testosterone levels , its about the balance between your testosterone and estradiol.

    Your test levels have improved, which is noted by your blood work. Your estradiol has also gotten high, again noted by your blood work. High estradiol levels can cause you to feel like garbage regardless of how high your testosterone levels are. Conversely, estradiol levels that are too low can make you feel like absolute crap.

    Get your estradiol under control and you'll start to feel better. Like Mike said, this will also help increase your testosterone levels even more. Will it bring your levels to where you have no more symptoms and do not need a higher dose of testosterone? That's impossible to answer, but it will definitely have you on the right track.

  20. #20
    MArz123 is offline Junior Member
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    I would also say that if your waiting for this "magically feeling" to come over you, it's probably not coming..., I think when we start many of us/ not all a get a "placebo" affect of well being and increased libido which will fade. I have found that it has taken me 5-6 months before I actually thought to myself "I feel great consistently" ...then I reflect back and see the past couple months a I have seen lots of improvements a little at a time of the course of 6 months.......give you body time to adjust and balance out, try to not want instant results, you are only setting yourself up for disappointment, in my humble opinion.

    At 5 weeks I doubt you can be dialed in and balanced yet!

    Best of luck, and be patient!
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  21. #21
    Remington's Avatar
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    Yeah....I understand it's a waiting game.
    I guess I relied too much on that sticky.
    Clearly it's gonna be a wait.
    FYI...still nothing.
    I DO agree with changing clinics though...
    I'm currently looking into 'another' place I found online.

  22. #22
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    It could very well be the clinic....even my facial hair has tripled its growth rate, and seems to be getting darker especially the mustache. So with seeing this, I have ruled out the placebo effect on myself. I am not for sure but seems like hair growth would be some kind of indication of something happening.

  23. #23
    dreadnok89 is offline Member
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    Oooo def laser. Same here bro. I love it
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  24. #24
    Remington's Avatar
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    One thing I HAVE noticed is the rogue acne that I never had before.
    One or two on my back.
    5 or 6 on my face.
    Nice.

  25. #25
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    Quote Originally Posted by Remington View Post
    Yeah....I understand it's a waiting game.
    I guess I relied too much on that sticky.
    Clearly it's gonna be a wait.
    FYI...still nothing.
    I DO agree with changing clinics though...
    I'm currently looking into 'another' place I found online.
    Bumping your test up right away really isn't the answer. You have decent levels already, which the addition of ai should get your numbers even higher. Recently my numbers were in 660 ish, with similar e2. I started ai again, and the changes are very minor, and overall i was feeling ok before, but it's even better now. Things are very very subtle. The only thing that really made me feel significantly different is HCG , the stuff is amazing. I've even blasted at 600 mg a week and it didn't have great libido gains or any other noticeable improvements. So more test is likely not the answer.

    When I started trt I was on 100 mg a week, test results came back with lower test levels than when I started. He only bumped it up 20 mg, but I was feeling absolutely awful, worse than pre trt. I took matters into my own hands, and found a new doctor. I don't think you need to do that just yet, give that AI some more time, and then even more time after that and you will start to realize your life is improving. Sometimes it also takes a lot of effort in other aspects of your life to make things work and improve. It isn't just magic, but you'll get there if you are trying.
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  26. #26
    pappybay is offline Junior Member
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    Quote Originally Posted by Metalject
    Quality therapy isn't just about your testosterone levels , its about the balance between your testosterone and estradiol.

    Your test levels have improved, which is noted by your blood work. Your estradiol has also gotten high, again noted by your blood work. High estradiol levels can cause you to feel like garbage regardless of how high your testosterone levels are. Conversely, estradiol levels that are too low can make you feel like absolute crap.

    Get your estradiol under control and you'll start to feel better. Like Mike said, this will also help increase your testosterone levels even more. Will it bring your levels to where you have no more symptoms and do not need a higher dose of testosterone? That's impossible to answer, but it will definitely have you on the right track.
    Great advice

  27. #27
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    Quote Originally Posted by Remington View Post
    Going into 5 weeks of this and still nothing?
    Started out like this:
    Testosterone , Serum---264 ng/dl
    Estradoil---21.0 pg/ml
    Prostate -Specific Ag--0.5
    Hemoglobin---14.6 g/dl

    New labs show this:
    Estradoil--52.7
    Test--682

    They started me on Anastrazole---so far a week of that.
    Nothing.
    Nothing at all.
    I think I need more Test---but what do I know?

    Any ideas?
    I know when they see the next labs---the TRT clinic I go to is going to say to give it time.
    I understand that...but..come on...I should feel SOMETHING now.

    How do I go about getting more T from the doc?
    Hey buddy hang in there! Feeling like crap ia what got me to this forum after almost 12 weeks of trt with the exeption that I'm on the oppso side of the page my test is around 700 but my E2 levels were garbage low (10) on my last Bw.
    I change doc and found a great guy that is more understanding about my situation being that he himself is on trt he made me stop my anastrozol and I have started to feel lot better I saw him today and he was explaining that too high or too low levea of E2 can cause same if not worst symptoms than low T so be patient get your E2 levels in line. My doc said it should be between 20-30
    Trust me I completly understand your frustration on trying to feel better but I can tell you from experience as you gwt xloser to your perfect levels your body will fell great

    Good luck!

  28. #28
    Brazensol's Avatar
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    Quote Originally Posted by HRTstudent View Post
    I never "felt" anything from being on TRT... even after a year now of having youthful testosterone levels .

    It takes time for stereotypes to fade ... but eventually I did look back and say, "Hey... that got better" or "This affliction is gone"... stuff like that.

    But I never woke up one day and said Aha! I'm superman!
    Mine experience has been the same. Did not happen overnight. Just started noticing after several weeks that things were getting better. Some guys claim they can feel a "test rush" soon after injecting but I've never experienced it. Just give it some more time. It takes longer for some than for others.
    HRTstudent likes this.

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