HCG high estradiol

[Jb3291]

27 yr old male with low test. Was placed on HCG 250 units eod.and tamoxifen 10mg twice daily. Got labs done estradiol was 92 and test serum 1200. Doc says add in arimidex 1mg once daily. So trying to get some opinions if this is going to work good or if it will bottom me out on estradiol with taking tomoxifen and arimidex. Thanks for any help

[kelkel]

Why HCG Mono? Most top doc's will tell you the benefits are not there long term. It's also suppressive of your natural LH over time. If your doc is giving you a SERM (tamox) to counteract this he's foolish. If he's giving it to help with E2 it won't. It will only block receptors in the breast, but your level will rise as you now know. HCG can/will elevate E2 but there are more factors that play into elevated E2 as well.

No doubt you need an AI in a low dose. Meaning the smallest effective dose. 1 mg of adex daily is a breast cancer dosage or a very heavy steroid cycle dosage. I don't think you need that as it will eventually crash your estrogen. Ultimately you need a proper E2 sensitive assay as Estradiol is geared for women, not men and tends to run higher leading to improper dosing of AI's.

My thoughts?

What caused your low T? Did your doc find the root cause?
If you continue mono therapy, lower your dose. Consider maybe smaller, daily dosing, imho.
If legitimately low in T production that is not fixable, consider other options.
Do you have current blood work from just prior to mono-therapy that you can post?

Welcome to the forum. Others will chime in.

[Jb3291]

I have secondary hypogonadism. I was put on the HCG to keep fertility high until done with children, then I will be placed on test. What do you think would be a good combo, .25 arimidex and the 10mg tomoxifen twice daily? Thanks for your help

[kelkel]

You don't need tamoxifen at all. Re adex .25 twice per week is probably a good starting point. Re-check your E2 with a SENSITIVE ASSAY in 4 weeks. I can provide you the proper test codes for Labcorp if you like.

And plenty of guys get their other halves pregnant on TRT with HCG .

Curious how you feel on this protocol Jb?

[Jb3291]

Doc has me set up for blood work for e2 and some other things in 6 weeks. I'm going to try the .25 twice a week. I knew taking both was just going to put me at rock bottom so I had to hear it from everyone on here that knows a whole bunch more than me. It also amazes me at how much a lot of docs don't know about this, especially the ones that specialize in this.

[kelkel]

Again, make sure you test "E2 Sensitive Assay, " not standard estradiol.

https://www.labcorp.com/wps/portal/!...l%2C+Sensitive

Taking both will not double the estrogen blocking effect. Only adex will reduce estrogen levels. Tamox will not.

[OingoBoingo]

Everyone is different, but 0.25mg Anastrozole would crash my E2. Been there, done that.

What seems to be working for me is to keep a log of my symptoms. In my case, a small outbreak of acne on arms or back, followed by flushing on neck and upper chest, then night-sweats. An Anastrozole dose of just 0.25mg will stop the symptoms.

It's also a good idea to keep track of the doses to see if any patterns develope; for example, in my case it seems a dose is needed every six days or so.

So the advice is to see if you can observe symptoms and let that be a guide to dose frequency.

[2Sox]

With only the information you have presented here so far, it's not difficult to conclude that your doctor is an incompetent moron. Are you sure you didn't leave anything out in your description? IMO this AI and Serms dosing is terribly irresponsible.

Kel was right about your Adex dose. But this needs to be said: 1mg of Adex per day is DANGEROUS.

My advice? Take Kel's advice. The other advice I'd give; find another doctor - FAST.

[Beethoven]

When I started Anastrozole, I was dosed at .5 every three days and not shockingly crashed my E2. The most I've taken since has been 1 mg for a week and not two weeks consecutively. Depends on my symptoms. I also upped my HCG to 1000 iu's which is another reason for a little more Anastrozole.