Can SSRI's have permanent sexual side effects (delayed ejaculation)

[waylaid69]

I took a high dose of Prozac nearly 20 years ago for a 2 year period.. During that time, I found it very difficult to ejaculate. I still have the same problem! Anyone else in the same boat?

[Keep_It_Moving]

I took a high dose of Prozac nearly 20 years ago for a 2 year period.. During that time, I found it very difficult to ejaculate. I still have the same problem! Anyone else in the same boat?

I take psy meds and i find it hard to ejaculate sometimes and also to keep a hard on... small price to pay for peace of mind tho. the GF doesnt mind too much so everything is ok in that department. i definitely feel your pain tho as it can be a pain in the ass.

[IncreaseMyT]

Although 5-HT has been the most studied neurotransmitter in depression, converging lines of evidence suggest that NE is of major importance in the pathophysiology and treatment of depressive disorder. NE projections from the locus ceoruleus innervate the limbic system, which is implicated in the regulation of emotions and cognition. Substantial functional biochemical differences exist in the NE system in postmortem brains from depressed patients and healthy controls. Genetic manipulation of the NE system that increases NE neurotransmission protects animals from stress-induced depressive behavior, while chemical manipulation that depletes the brain of NE increases the susceptibility of recovered depressed patients to a depressive relapse. Therapeutic agents which specifically increase NE activity are effective antidepressants, and there is evidence that those acting simultaneously on 5-HT and NE neurotransmission may have an antidepressant action superior to SSRIs.50

The importance of norepinephrine in depression

[IncreaseMyT]

Dietary Sources

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D-phenylalanine is made in the laboratory but is not found in food.

Available Forms

D-phenylalanine
L-phenylalanine
DL-phenylalanine (50/50 blend of D-phenylalanine and L-phenylalanine)
You can take phenylalanine as a capsule, powder, or tablet. You can also apply it as a topical cream.

Phenylalanine | University of Maryland Medical Center

[hammerheart]

I took a high dose of Prozac nearly 20 years ago for a 2 year period.. During that time, I found it very difficult to ejaculate. I still have the same problem! Anyone else in the same boat?

A lot of people report permanent sides from SSRI/SNRI... I was prescribed venlafaxine a couple of years ago which I refused to take. Glad I was informed enough to stay away from that s**t.

There is some evidence that dopamine agonist can reverse the sexual dysfunction that comes with SSRI use, if you are interested.

The importance of norepinephrine in depression

I've tried many serotonergics compounds and only got sides from them, no benefits. The only stuff that helped is cathecolamine enhancers/precursors like l-tyrosine, levodopa, and the anti-parkinsonian drug selegiline.

I might also add I end up feeling asexual every time I upgrade thyroid hormone dosage, which also enhance serotonin in the brain. It usually lasts about a couple of weeks. Note that thyroid hormone upregulates serotonin receptors (mainly post-synaptic 5-HT2a) in a opposite fashion compared to SSRI, which downregulate the receptors. If I were to take an SSRI, I'd probably get a permanent shutdown in sexual function.

[MuscleScience]

Alot of research is coming out that the major cause of depression is chronic inflammation. Secondly we are just scratching the surface on the role that gut flora plays on our moods.

[macmathews]

Alot of research is coming out that the major cause of depression is chronic inflammation. Secondly we are just scratching the surface on the role that gut flora plays on our moods.

Huge link - gut and mind -

Mac

[waylaid69]

I no longer feel depressed, but still have the delayed ejaculation. Very often I cannot ejaculate at all, so need to fake that I am enjoying it, when really I cannot feel much pleasure in my dick at all.
What are some examples of dopamine agonists?
Thanks.

[hammerheart]

Cabergoline is the most popular "underground". People on cycles use it to control prolactin while on tren /deca ... and is the one associated with the least sides, but you cannot stay on it indefinitely.

Be careful, messing with brain dopamine can prove dangerous, these drugs can have very serious sides (including psychiatric).

[Proximal]

I took a high dose of Prozac nearly 20 years ago for a 2 year period.. During that time, I found it very difficult to ejaculate. I still have the same problem! Anyone else in the same boat?

Perhaps at that time it was the wrong dosage and/or wrong antidepressant. There is a process of trial and error involved in both.

Personally, I've been on a mild dose of Prozac for about 20 years now and have experienced amazing success & never had any side effects. Regarding cabergoline, I'm going on 3 years usage due to a pituitary tumor & once again no side effects to speak of.

[waylaid69]

Cabergoline is the most popular "underground". People on cycles use it to control prolactin while on tren /deca ... and is the one associated with the least sides, but you cannot stay on it indefinitely.

Be careful, messing with brain dopamine can prove dangerous, these drugs can have very serious sides (including psychiatric).

Thanks. I did try taking Mucuna Pruriens, containing 15% L-dopa, but had a very bad reaction to it (hot flushed face, sweaty palms, tingling feeling down my arms and anxiety). Do you think that would suggest I would not respond well to cabergoline, or does cabergoline work very differently than mucuna?

[IncreaseMyT]

We think Caber has the lowest amount of sides in the class.

Hope this helps.

[hammerheart]

Difficult to say. Mucuna features not only levodopa but other psycho active molecules as well.

Cabergoline works by doing the job of dopamine at its receptor, which translates its action, while levodopa is the precursor of dopamine (and it can be further converted to nor(adrenaline)), and very little of it make it into the brain, if ingested. Mucuna extract is in fact a very weak compound.

Consider also that caber has a very long half-life of about 60 hours. If you are going to get sides from it, they might last a few days, but they should be mild anyway.

[waylaid69]

Thanks. What is the starting dose for caber?

[hammerheart]

You get 0.5 mg tablets, half (0.25) two times a week is a standard dose, but I'd start as low as .125.

[LeeSin1]

i heard that it normally goes away. i took some for awhile and i don't know if i had any side effects, honestly