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Thread: Guys on Nebido: how long before you started to feel the effects?

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    markwilliams is offline New Member
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    Guys on Nebido: how long before you started to feel the effects?

    Hello,

    I was wondering what was your experience with the standard Nebido protocol. I'm aware of the chart on their website and the studies, if you want to share your experience, I'm all ears.

    I started my first injection 15 days ago, no improvements so far. My doc wants me to skip the booster, so my next injection will be in two months and a half from today.

    Cheers

  2. #2
    hollowedzeus's Avatar
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    I feel 'better' so to speak. I feel different. Sex drive hasnt picked up very much yet. But ive just went 10 weeks without a shock and good god did i feel like a bag of shit.

    Just had my 3rd pin there.

    Absolutely do not skip the booster. Inform him that the manufacturer highly recommends the booster shot to achieve stable levels quicker.

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    Back In Black's Avatar
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    Agreed don’t skip the booster.

    I felt ‘normal and stable’ after about 12 months but started to feel good a couple of weeks after my 3rd shot
    NO SOURCES GIVEN

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    markwilliams is offline New Member
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    I tried to convince my end but there's nothing I can do, he says that the booster protocol is now outdated and would put me at a significant cardiac risk. I have a heart disease history in my family but that doesn't justify the fact that he's the first one that I hear saying that the booster protocol is now outdated.

    I'm not coming from other forms of test, just starting TRT for my first time.

  5. #5
    hollowedzeus's Avatar
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    If he looks in the patient information leaflet thats enclosed next the vial it reccomends the booster at 6 weeks if symptoms dictate, which they likely do if you needed trt

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    markwilliams is offline New Member
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    Quote Originally Posted by hollowedzeus View Post
    If he looks in the patient information leaflet thats enclosed next the vial it reccomends the booster at 6 weeks if symptoms dictate, which they likely do if you needed trt
    I explained that to him, and he said that he knew, but that protocol is outdated. Reading the various stories of people starting TRT I thought I had been lucky since I met an endo that treated me with care and respect... until I realized that he's very conservative and has these fixed ideas regarding Nebido. It makes me wonder: if he's so fixed on his protocol, it will be hard to adjust together one that suits me, in the future. Damn. But he's the one prescribing me the drug, three vials at a time.

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    hollowedzeus's Avatar
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    I personally wouldnt say it's outdated. I know i would be feeling worse had i missed the booster.

    I dont know how you will change his mind then... it wont hurt you not getting the booster but it may take a few months longer to feel better than it would be id you had it.

    3 vials is alot at once... im prescribed 1 at a time on the condition i let the nurse inject me with it....

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    markwilliams is offline New Member
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    Not at once. I need to buy three vials with a single prescription, return to my endo to get a new one every nine months, repeat for life.

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    Quote Originally Posted by markwilliams View Post
    I explained that to him, and he said that he knew, but that protocol is outdated. Reading the various stories of people starting TRT I thought I had been lucky since I met an endo that treated me with care and respect... until I realized that he's very conservative and has these fixed ideas regarding Nebido. It makes me wonder: if he's so fixed on his protocol, it will be hard to adjust together one that suits me, in the future. Damn. But he's the one prescribing me the drug, three vials at a time.

    Since when and according to who is the protocol outdated? I don't recall seeing anything changes in protocol from Nebido.
    -*- NO SOURCE CHECKS -*-

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    Mr.BB's Avatar
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    What benefits are you expecting? Seems you have hyped expectations.

    Been on Nebido for years now, at over 11 weeks im over 600 ng/dl.

    Really dont recommend missing the booster shot.

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    markwilliams is offline New Member
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    Quote Originally Posted by Mr.BB View Post
    What benefits are you expecting? Seems you have hyped expectations.
    I'm expecting something to happen in general, I feel like I never took the first injection. Literally nothing happened except a few red bumps on my ass. That's why I was worried, I'm in week three and I feel I should feel something, but correct me if I'm wrong.

    What I'm expecting from Nebido?

    Not feel like shit all the time since I was 20 (I'm 29), better body composition, better well-being while dieting (my hormones crash if I stay in a caloric deficit for more than a few days), not feeling anymore my symtomps of derealization.

    Before injecting I was 189 ng/dL. Free Test: 61 pg/mL (range: 75 - 124).

  12. #12
    Mr.BB's Avatar
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    Nebido its a great protocolo, and it works for the vast majority of ppl, but at the end of the day it's just an hormone.

    From your blood values it seems you need it, hopefully you and your doctor did the work of finding out the underlying reason for low testosterone , low testosterone at your age is a symptom of some other underlying condition or trauma.
    If the cause for your problems is this underlying condition, patching it with testosterone may not produce any results.

    Nebido is a slow protocol, furthermore being for long periods with low testosterone usually desensitizes receptors, meaning that some of the symptoms can take up to a year to get results, the best example of this is erectile dysfunction.

    We are all different in how we feel it, but sexual desire is usually the first thing to improve upon starting trt protocol. But like I said of you have been low for a long time it may take sometime till your receptors get saturated and your brain recognizes it.

    Be patient, and don't expect too much too soon.

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    markwilliams is offline New Member
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    Quote Originally Posted by Mr.BB View Post
    From your blood values it seems you need it, hopefully you and your doctor did the work of finding out the underlying reason for low testosterone , low testosterone at your age is a symptom of some other underlying condition or trauma.
    If the cause for your problems is this underlying condition, patching it with testosterone may not produce any results.
    I have a small pituitary gland, I did a MRI and that's what came out.
    I also did a DEXA to my bones to know when this started and apparently I've been suffering from years since my bone density was deteriorating.


    Quote Originally Posted by Mr.BB View Post
    Nebido is a slow protocol, furthermore being for long periods with low testosterone usually desensitizes receptors, meaning that some of the symptoms can take up to a year to get results, the best example of this is erectile dysfunction.
    Is there a scientific study to back this up? It's the first time I hear this. I'm just genuinely curious.

    On an unrelated note, I'm currently fighting two nasty abscesses near injection site, 18 days after my first injection. They appeared three days ago, and I'll probably need surgery to cut them. It sucks, but I don't think it's related to Nebido.

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    Quote Originally Posted by markwilliams View Post
    I have a small pituitary gland, I did a MRI and that's what came out.
    I also did a DEXA to my bones to know when this started and apparently I've been suffering from years since my bone density was deteriorating.




    Is there a scientific study to back this up? It's the first time I hear this. I'm just genuinely curious.

    On an unrelated note, I'm currently fighting two nasty abscesses near injection site, 18 days after my first injection. They appeared three days ago, and I'll probably need surgery to cut them. It sucks, but I don't think it's related to Nebido.
    Sorry to hear about your pituitary problems, but at least you know whats going on.

    There is definitely information about long term low testosterone taking more time to recover. For example this study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754577/) shows Androgen Deprivation Therapy (ADT) patients with longer than 18 months ADT took 9.7 months to recover, while patients with less than 18 months ADT only took 6.8 months for the same recovery.

    The explanation about why that happens its my own thesis, so thats definitely not certain heheh. Take it with a grain of salt.

    About the abscesses, who injected you? You need someone experienced in injecting this stuff. If its just your body fighting a foreign substance if you surgically remove it you are removing the actual nebido. If its not nebido related what is it??
    hollowedzeus likes this.

  15. #15
    hollowedzeus's Avatar
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    Quote Originally Posted by Mr.BB View Post
    Sorry to hear about your pituitary problems, but at least you know whats going on.

    There is definitely information about long term low testosterone taking more time to recover. For example this study (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754577/) shows Androgen Deprivation Therapy (ADT) patients with longer than 18 months ADT took 9.7 months to recover, while patients with less than 18 months ADT only took 6.8 months for the same recovery.

    The explanation about why that happens its my own thesis, so thats definitely not certain heheh. Take it with a grain of salt.

    About the abscesses, who injected you? You need someone experienced in injecting this stuff. If its just your body fighting a foreign substance if you surgically remove it you are removing the actual nebido. If its not nebido related what is it??
    Thats interesting. I never knew that.

    Thanks

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    markwilliams is offline New Member
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    Quote Originally Posted by Mr.BB View Post
    About the abscesses, who injected you? You need someone experienced in injecting this stuff. If its just your body fighting a foreign substance if you surgically remove it you are removing the actual nebido. If its not nebido related what is it??
    I have two different abscesses, one a few centimeters lower than the injection site, and one slightly left near the hip. They look like I have a ping pong ball under my skin.

    I had an ultrasound two hours ago and it confirmed they're two abscesses, and I'm currently taking antibiotics to fight the ongoing infection. I really hope I won't need surgery, they say recovery is long and painful.

    I talked to my endo after the ultrasound, and he told me that he never heard of someone having a reaction like that to Nebido, not 18 days after the injection.

    So we're thinking a mosquito or spider bite, but that's unlikely too, IMHO.

  17. #17
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    Quote Originally Posted by markwilliams View Post
    I have two different abscesses, one a few centimeters lower than the injection site, and one slightly left near the hip. They look like I have a ping pong ball under my skin.

    I had an ultrasound two hours ago and it confirmed they're two abscesses, and I'm currently taking antibiotics to fight the ongoing infection. I really hope I won't need surgery, they say recovery is long and painful.

    I talked to my endo after the ultrasound, and he told me that he never heard of someone having a reaction like that to Nebido, not 18 days after the injection.

    So we're thinking a mosquito or spider bite, but that's unlikely too, IMHO.
    Who injected the nebido in you?

  18. #18
    hollowedzeus's Avatar
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    Might be from poor sanitation before pinning?

  19. #19
    markwilliams is offline New Member
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    My family doctor did the injection with a sterile, new syringe. He read carefully Nebido's instructions. The injection was a little fast though, I did not count but it felt approximately a minute instead of two.

  20. #20
    hollowedzeus's Avatar
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    Quote Originally Posted by markwilliams View Post
    My family doctor did the injection with a sterile, new syringe. He read carefully Nebido's instructions. The injection was a little fast though, I did not count but it felt approximately a minute instead of two.
    Possibly unrelated to the nebido then mate. Hope it gets sorted alright and doesnt require surgery.

    I inject it pretty quick so dont think its anything to do with that

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    markwilliams is offline New Member
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    Quote Originally Posted by hollowedzeus View Post
    Possibly unrelated to the nebido then mate. Hope it gets sorted alright and doesnt require surgery.
    I inject it pretty quick so dont think its anything to do with that
    Cheers mate. It's my second day of antibiotics and things start to look better. I'll keep you guys posted. Thanks!

  22. #22
    markwilliams is offline New Member
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    Quick update: I'm on week five, and except some hot flashes and a few morning erections in week two, I feel worse than when I started. Gonna have the booster after all, so I'll keep you posted.

    Is this normal? To feel shitty/regular shitty during the first few weeks?

  23. #23
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    Quote Originally Posted by markwilliams View Post
    Quick update: I'm on week five, and except some hot flashes and a few morning erections in week two, I feel worse than when I started. Gonna have the booster after all, so I'll keep you posted.

    Is this normal? To feel shitty/regular shitty during the first few weeks?
    Back to teenage years, huh?

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    Epiphone84 is offline New Member
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    I felt pretty shit after what im assuming was my body stopping its own production of Test. I didnt get the booster shot after 6 week (i begged for it after my second injection tho) Right now im about 8 months on Nebido, and have from the looks of it, finaly gotten to the point where the rate of injections (8 weeks atm) and the effect of Nebido is realy starting to work. I feel much much better now then before (and during the first months) So based on me and what others say, it takes time to get this to work.

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    Epiphone84 is offline New Member
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    Oh, and also, i got a rash / lumps under the skin after my first injection (it was done by my GP) Sadly i dont know why it happened tho

  26. #26
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    Quote Originally Posted by Epiphone84 View Post
    I felt pretty shit after what im assuming was my body stopping its own production of Test.
    Moody balls?

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    Quote Originally Posted by Mr.BB View Post
    Moody balls?
    In the sence that i think its "normal" to get a high at first, then a low after the body stops producing test. And then it gets better once the nebido builds up over the next injections

    (didnt want to hijack the thread)

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    UPDATE

    I have my bloods, end of week five after my first injection, I'm still trying to figure out why I feel like shit.

    TEST: 4.37 ng/mL (range 2.4 - 8.27)
    HEMOCHROME - Red blood cells 5.52 (range 4.00 - 10.80)
    HEMATOCRIT: 48.4 (42,0 - 52,0)
    ESTRADIOL: 39.46 (range <39.8)
    SHBG: 30.9 (range 13 -71).

  29. #29
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    Quote Originally Posted by markwilliams View Post
    UPDATE

    I have my bloods, end of week five after my first injection, I'm still trying to figure out why I feel like shit.
    What was the cause for the hypogonadism?

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    markwilliams is offline New Member
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    A small pituitary gland, I did a MRI. My endo told me that I was born with that and it didn't become small all of a sudden.
    We did a Bone Mineral Density scan and found that my bones don't have a perfect mineral density, so we thought that my condition started many years ago.

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