Low dose deca causing problems

**Painjunky** · 04-23-2023, 06:09 PM

So Im a month in from adding 150mg deca weekly to my trt protocol.
My nipples feel like they are inside out and some pea size gyno is flaring up.
My labs came back with my prolactin at 20.7 (2.0-18.0 ng/ml )
And my E2 is 95 <or=29 pg/ml About 35 points higher than normal.
I have zero of the common sides from high prolactin, in fact quite the contrary. So I’m not sure I want to go the caber route just yet. Unfortunately I’ve gotta drop the deca . This is the second time I’ve tried it and have had the same issues show up. I’m taking 20 mg of nolva for the next few weeks for the nips . I’m wondering if anyone else has been so hyper sensitive to deca and if I should just ride it out until it’s out of my system and re test or take something for it.

**< <Samson> >** · 04-23-2023, 06:46 PM

I had no sides at all of 125mg of therapeutic a week of Deca . Ran it for months for my joins & ligaments.

But, I did have a mastectomy & never had my PCP pull prolactin levels.

**Cylon357** · 04-23-2023, 07:27 PM

Originally Posted by Painjunky

So Im a month in from adding 150mg deca weekly to my trt protocol.
My nipples feel like they are inside out and some pea size gyno is flaring up.
My labs came back with my prolactin at 20.7 (2.0-18.0 ng/ml )
And my E2 is 95 <or=29 pg/ml About 35 points higher than normal.
I have zero of the common sides from high prolactin, in fact quite the contrary. So I’m not sure I want to go the caber route just yet. Unfortunately I’ve gotta drop the deca . This is the second time I’ve tried it and have had the same issues show up. I’m taking 20 mg of nolva for the next few weeks for the nips . I’m wondering if anyone else has been so hyper sensitive to deca and if I should just ride it out until it’s out of my system and re test or take something for it.

Two quick thoughts

P5P and Vitamin E can likely help bring that prolactin under control. Google for doses, but IIRC, it doesn't take a whole lot of either.

A DHT derivative, like mast or primo, could nudge down the E2 (or at least it's effect). I personally like masteron , and it is cheaper than primo, not to mention the fact that masteron was / is a breast cancer drug and gyno prevention and reversal is right up its alley.

It didn't take much mast to tank my e2, verified with bloodwork, so if you decide to go that route, maybe start mast at 1 to 1 with your test.

**Painjunky** · 04-23-2023, 07:30 PM

That seems like the norm for most. It’s what I was hoping for too.
After a lot of digging with the search button , I found an old thread about someone with my same issue. Said letro was the only thing that stoped the gyno in its tracks. I’ve got an ai on hand but have never had to take it and don’t really want to. I’m not sure if my side effect is from prolactin or estrogen yet anyway.

**Painjunky** · 04-23-2023, 07:32 PM

I have primo on hand but only 2000mg total though and no source to get more
Also my dht is up to 93 this time around.

**Painjunky** · 04-23-2023, 07:36 PM

I’ll look into p5p and vitamin E thanks.

**Cylon357** · 04-23-2023, 08:31 PM

Originally Posted by Painjunky

I have primo on hand but only 2000mg total though and no source to get more
Also my dht is up to 93 this time around.

Read the write up on masteron . Primo will do part of the job, but it doesn't bind to the estrogen receptors like mast.

You haven't lived until you have had your dht close to triple digits lol! I had mine as high as 215 (15 to 65 scale or whatever it is exactly). Call me Sir Pees-a-Lot... not a lot all at once, but lots of times in the day!

**Cylon357** · 04-23-2023, 08:33 PM

To add, the combo of low estrogen, high dht and some other compound binding to the breast receptors spells death for gyno. You might be able to use an ai and nolvadex in place of mast or primo, I guess?

**Painjunky** · 04-24-2023, 05:12 AM

I’ve got both. I’m taking 20mg of nolva a day right now. I may start the ai if I absolutely have to. Worried about crashing estrogen. The gyno is there but very small . Doesn’t bother me at all unless I flair them up with high e2 or prolactin.
I certainly don’t want to pee anymore than I do now.
3x overnight is too much already!

**Scorpion0922** · 04-26-2023, 06:47 PM

Kudos for stopping the deca , a lot of guys are too stubborn to bail out when something like this happens.

**Painjunky** · 04-27-2023, 07:48 AM

Thanks but may have a little stubbornness to shake off.
Seems the most recent consensus is that deca with test lowers shbg which increases free t hence increasing test sides. Unfortunately I didn’t run a lab for that this time around although in the past shbg always hovered around 25-29 10-50nmo1/L
Im considering on lowering my t dose to from 40mg e3days to 30mg and add 100mg of primo week possibly re introducing deca at 40mg e3days after a month or so. . My goal is to lower e2 and prolactin while sticking with the deca over the next few months and see if I get any of the joint relief benefits from deca. If not Ill just consider this a so called “blast” and return to my normal protocol.
I could also speed up lowering my e2 with 1/8 mg 2xweek of anastrozol for 2-3weeks. Never used an ai though and have heard the nightmares of crashing e2.
If anyone has advice, critique or similar experiences I’d love to hear it!

**Testie** · 04-27-2023, 08:10 PM

Originally Posted by Cylon357

Two quick thoughts

P5P and Vitamin E can likely help bring that prolactin under control. Google for doses, but IIRC, it doesn't take a whole lot of either.

A DHT derivative, like mast or primo, could nudge down the E2 (or at least it's effect). I personally like masteron , and it is cheaper than primo, not to mention the fact that masteron was / is a breast cancer drug and gyno prevention and reversal is right up its alley.

It didn't take much mast to tank my e2, verified with bloodwork, so if you decide to go that route, maybe start mast at 1 to 1 with your test.

P5P works surprisingly well for me I think I’m at 100 mg twice daily and running Tren without masteron and it’s usually a given that I get a little gyno with straight Tren

**Cylon357** · 04-27-2023, 08:47 PM

Originally Posted by Testie

P5P works surprisingly well for me I think I’m at 100 mg twice daily and running Tren without masteron and it’s usually a given that I get a little gyno with straight Tren

This of course means that the FDA will be coming for P5P next...

**Painjunky** · 04-28-2023, 01:14 PM

Started p5p yesterday. 150mg once a day.

**Painjunky** · 05-10-2023, 06:11 PM

Update:
About 3 weeks from my last deca shot . 2 weeks in on 50mg primo e3days 150mg/day p5p and vitamin E. 1 week in 20mg of tamoxifen ed. No AI . My nips are completely back to normal. Think I’ll drop the tamoxifen finish out the month with p5p and ve.
How long should I wait to re test e2 , dht and prolactin?

**kelkel** · 05-11-2023, 06:34 AM

You may find this interesting:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700694/

**Painjunky** · 05-12-2023, 07:41 AM

Cool thanks for the link

**Too-$mall** · 05-19-2023, 05:37 PM

OP you're as sensitive to 19 nors and E2 as i am. maybe even more sensitive. lots of good stuff in this thread! had no idea about p5p and vitamin E

**redz** · 05-28-2023, 06:31 PM

I must be one of the lucky ones, 750 deca , 400 tren ace and 400test p with 60mg winny daily and no issues. I’m always shocked how some people get issues when taking crazy low doses. I also tss as me 150mcg t4 and 6ius hgh.

**< <Samson> >** · 05-29-2023, 05:16 PM

Originally Posted by < <Samson> >

I had no sides at all of 125mg of therapeutic a week of Deca . Ran it for months for my joins & ligaments.

But, I did have a mastectomy & never had my PCP pull prolactin levels.

Just re-read the thread & thought id quote myself

I had my prolactin pulled for my last bw, I was still on a super low Deca dose & it came within range - I was a tad scared for second. No clue what it’d actually look like & I don’t wanna be booted off trt.