what results should i look for from IGF1lr3?

[Gappa]

This is my first round of IGF and would like to know what I may expect to see from it. I am 240lbs@10%bf 33years old with 15years of hard training. Diet is very clean and supplementation is of excellent quality.

[higherdesire]

1-2 lbs of lean mass every two to three weeks is the real life application. How much are you running? How long?

[peteroy01]

u on a cycle or GH with this

[Gappa]

I am taking 200mgs Test Prop and 100mgs Tren Ace EOD

[Gappa]

I am 5 days in I started @50mcg bilaterally PWO. Just bumped to 100mcg BIL-PWO
I dont know about how long to be on it.. As long as I continue to see results I will keep going as money is no object.

[Gappa]

I can feel what has to be the peptides working already. Very hard to put my finger on exactly what is different but I like what I am feeling.

[peteroy01]

u will feel pumps and increased hunger due to the insulin like properties. its awesome after workouts with some protein and carbs. it'll will shuttle them bastards. i dont have the nutz to mess with insulin so LR3 is what i go to to help with recovery. have fun and let the gains begin!

[peteroy01]

o yeah, a decent protocol is 4wks on 4wks off but ive heard as long as 6wks but i think thats pushing it imo. 4 has worked for me.

[ScotchGuard]

I read a pretty in depth explanation of IGF-lr3 and the author as advocating 50mcg 3 times per week IM PWO. He was saying that this dosage could be sustained indefinitely as long as the IGF receptors were reset with hard workouts. I'm also reading that IGF should be cycles 4wks on 4wks off.

The first article said that anything over 50mcg 3 times per week will grow your intestines and cause that "perma gut" profile. I've been doing the 50mcg 3 times per week regement and have had good results. I'd be very interested to know what others think about the 50mcg 3 times per week versus 4weeks on and 4weeks off cycle.

Please excuse my entry I don't mean to steal the thread. I thought it would be good information for IGF users.

[tripmachine]

I read a pretty in depth explanation of IGF-lr3 and the author as advocating 50mcg 3 times per week IM PWO. He was saying that this dosage could be sustained indefinitely as long as the IGF receptors were reset with hard workouts. I'm also reading that IGF should be cycles 4wks on 4wks off.

The first article said that anything over 50mcg 3 times per week will grow your intestines and cause that "perma gut" profile. I've been doing the 50mcg 3 times per week regement and have had good results. I'd be very interested to know what others think about the 50mcg 3 times per week versus 4weeks on and 4weeks off cycle.

Please excuse my entry I don't mean to steal the thread. I thought it would be good information for IGF users.

^^^bump.... good point i'd like to hear some opinions on that as well..

[higherdesire]

I did a 6 wk cycle of 80mcgs ed. Nothing stupid dramatic in results but did have nice pumps and no real sides. I have put on a total of 6 lbs right now, but have been on gh for 8 weeks as well. Not super impressed with the igf but have a cycle left so will do it towards the end of the cycle I am on now though.

[Gappa]

I am blown away by the results of my first 15 days and the first 1mg vial of my IGF-1lr3. I have undergone a minor "miracle" transformation within the past two weeks even while cheating on my diet pretty frequently. My lower abs and crotch are snaked with veins and great definition all happened in two weeks. I can actually see the new development especially in my upper chest where I really focused the site injections. I am very confident in my source now as providing highly potent top quality "research materials". I am going to throw in my next order a nice supply of PEG-MGF along with a nice long rip of more of the lr3....

[myturn]

if you put on 6 lbs. in 6 wks only using the hgh and igf-1lr3 i would say that is very good

[Swifto]

I am blown away by the results of my first 15 days and the first 1mg vial of my IGF-1lr3. I have undergone a minor "miracle" transformation within the past two weeks even while cheating on my diet pretty frequently. My lower abs and crotch are snaked with veins and great definition all happened in two weeks. I can actually see the new development especially in my upper chest where I really focused the site injections. I am very confident in my source now as providing highly potent top quality "research materials". I am going to throw in my next order a nice supply of PEG-MGF along with a nice long rip of more of the lr3....

Its not gains in LBM. IGF-1 LR3 will NOT yield gains in LBM. Its nothing but a very expeneive GDA. Your experiencing nothing more than water retention.

1-2 lbs of lean mass every two to three weeks is the real life application. How much are you running? How long?

Again, LR3 wont put "1-2lbs" on you.

Its utter bullshit.

IGF-1 will, but I severly doubt you'll be able to get hold of real IGF-1.

Your doing nothing but burning a hole in your wallet.

No offence to both of you, but you need to read up on LR3.

[ScotchGuard]

I have read threads that claim that IGF is a total scam. That IGF does absolutely NOTHING for you. These threads were written by seemingly experts in this area. I think there are people on both sides of the IGF camp. For me, the proof is in the pudding. I cycled IGF and it gave me really good pumps. As for gains? I did IGF only with nothing else for two months @ 50mcg ed. I actually didn't know it was IGF. I thought I was pinning HGH. Nevertheless, I got results. Got stronger and got good pumps. At the end of month 2 I realized my mistake and switched to HGH and pinned IGF @ 50mcg eod. Continued to get gains of strength and size. The size gains were slow. NOTHING like my experience with AAS. So, the $2 question is: Does IGF work? I would say it worked for me.

[myturn]

would like to know if you have to worry about anti bodies with igf-1lr3 or any thing else and if so would you test with a spectrum analysis or other way? i have been looking for a thread on this but cannot find also am i right to assume that igf-1lr3 is not regulated and it is legal to buy? any one.

[myturn]

bump

[Swifto]

would like to know if you have to worry about anti bodies with igf-1lr3 or any thing else and if so would you test with a spectrum analysis or other way? i have been looking for a thread on this but cannot find also am i right to assume that igf-1lr3 is not regulated and it is legal to buy? any one.

You can obtain IGF-1 LR3 for research purposes, yes.

But its a ****ing complete waste of money.

[goose]

You can obtain IGF-1 LR3 for research purposes, yes.

But its a ****ing complete waste of money.

Id prefer inject toilet water (this is a guy who ran it at 160mcg for 40 days,LOL)

[time 4 a *CHANGE*]

how come regular igf-1 isn't around anymore?

[Swifto]

how come regular igf-1 isn't around anymore?

It was never licesnsed for medical purposes I dont think. Goose may be able to add to this.

[time 4 a *CHANGE*]

also does igf-1 lr3 act any different in the body than regular igf-1????

[The Deuce]

SO basically IGF-LR3 is like CREATINE.. useless...

[higherdesire]

Its not gains in LBM. IGF-1 LR3 will NOT yield gains in LBM. Its nothing but a very expeneive GDA. Your experiencing nothing more than water retention.



Again, LR3 wont put "1-2lbs" on you.

Its utter bullshit.

IGF-1 will, but I severly doubt you'll be able to get hold of real IGF-1.

Your doing nothing but burning a hole in your wallet.

No offence to both of you, but you need to read up on LR3.

Wow someone hasnt eaten their wheaties in awhile. Lighten up swifto you have your opinion and as you know this is a debated topic among many with many quality points on both side of the argument. To say that my results were bullshit is out of line. I am not parroting information player, I had this exact experience with my cycle.

IGF stands for insulin -like growth factor. Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin . It plays an important role in childhood growth and continues to have anabolic effects in adults. It is a natural substance that is produced in the human body and is at its highest natural levels during puberty. During puberty IGF is the most responsible for the natural muscle growth that occurs during these few years. There are many different things that IGF does in the human body. Among the effects the most positive are increased amino acid transport to cells, increased glucose transport, increased protein synthesis, decreased protein degradation, and increased RNA synthesis.

Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF's. When IGF is active it behaves differently in different types of tissues. In muscle cells proteins and associated cell components are stimulated. Protein synthesis is increased along with amino acid absorption. As a source of energy, IGF mobilizes fat for use as energy in adipose tissue. In lean tissue,

IGF prevents insulin from transporting glucose across cell membranes. As a result the cells have to switch to burning off fat as a source of energy.

[higherdesire]

IGF Effects and Results

Perhaps the most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use , it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don't actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.

Another frequently asked question of IGF refers to the real world results. With an effective dosage you can expect to gain 1-2 lbs of new lean muscle tissue every 2-3 weeks. Increased vascularity is also very common, people report seeing veins appear where they never have before.

Overall, IGF is a very exciting drug due to its ability to alter ones genetic capabilities.

[higherdesire]

Insulin -like growth factor 1 - IGF-1 LR3 Dosage

The most used dosages range between 20mcg/day to 120+mcg/day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20mcg/day, 2mg will give you a 50 day cycle at 40mcg/day, 3mg will give you a 50 day cycle at 60mcg/day, 4mg will give you a 50 day cycle at 80mcg/day and so on. The dosage issue mainly revolves around how much money you have to spend, plenty of people use the minimum dosage of 20mcg/day and are happy with the results. IGF is most effective when administered subcutaneous and injected once or twice daily at your current dosage. The best time for injections is either in the morning and/or immediately after weight training (if used for body building).

[higherdesire]

Insulin -like growth factor 1 - IGF-1 LR3 - Information

IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."

IGF Cycles

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage.

[higherdesire]

Hope this helps

[higherdesire]

Although the mechanisms underlying age associated muscle loss are not entirely understood, researchers attempted to moderate the loss by increasing the regenerative capacity of muscle. This involved the injection of a recombinant adeno-associated virus directing overexpression of insulin -like growth factor I (IGF-I) in differentiated muscle fibers.

They demonstrated that the IGF-I expression promotes an average increase of 15% in muscle mass and a 14% increase in strength in young adult mice (Figure 1), and remarkably, prevents aging-related muscle changes in old adult mice, resulting in a 27% increase in strength as compared with uninjected old muscles (Figure 2). Muscle mass and fiber type distributions were maintained at levels similar to those in young adults. These results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated.

Discussion:
I’m not sure where to begin. This study has the potential to completely change the way we age.

In this experiment, a recombinant adeno-associated virus, directing overexpression of insulin-like growth factor I (IGF-I) in mature muscle fibers, was injected into the muscles of mice. The DNA that was originally in the virus was removed along with markers that stimulate immune response. DNA coding for IGF-1 was then put into the virus along with a promoter gene to ensure high rates of transcription. The results, as you can see by figures 1 & 2, were dramatic.

IGF-1 plays a crucial role in muscle regeneration. IGF-1 stimulates both proliferation and differentiation of stem cells in an autocrine-paracrine manner, although it induces differentiation to a much greater degree. IGF-1, when injected locally, increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. The importance of IGF-1 lies in the fact that all of its apparent functions act to induce muscle growth with or without overload although it really shines as a growth promoter when combined with physical loading of the muscle.

IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.

The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.

The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.

The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.

In this study there was a preferential preservation of type IIb muscle fibers in aging mice. These are the fibers most sensitive to muscle hypertrophy from training and they are also the first fibers to disappear with aging. In the mice receiving the engineered virus, there was also a preservation of the motor neuron, leading to an increase in functional capacity. It is speculated that age related muscle loss is secondary to the loss of neuronal activation of type-II fibers. By preventing the degeneration of typ-II motor units, functional capacity could be maintained into old age. This technique may also serve useful in the prevention of osteoporosis. Further study is necessary to determine wether IGF-1 is having an effect only on muscle fibers or on nervous tissues as well.

Finally, it was also exciting to see muscle growth in the young mice who received the injection (15% increase in muscle mass). This means that the injection provided levels of IGF-1 far and above what the muscle normally has access to and not simply a preservation of normal levels. Remember that this was not combined with exercise. The growth of the injected muscles happened even without an extreme mechanical stimulus. The mice were simply allowed to run around as they usually do. Because of these dramatic results, the authors expressed concern about the use of this technique to enhance performance or cosmetic appearance. Research Update is not my personal soap box so I won’t go off on the gender centered hypocrisy of cosmetic enhancement in our society. All we can hope for is that this technique will be used to treat more important diseases such as muscular dystrophy and thereby become somewhat available for other uses as well.

[time 4 a *CHANGE*]

HIGH DESIRE...how much lr3 were runnin to see 1-2lbs every 2 to 3 weeks?

[higherdesire]

I had about 6 pounds in 6 weeks and i was on 80mcg ED PWO. I was also taking 3Iu's ed HGH but had only been on for a couple of weeks so I dont think it had anything to do with it at all

[Swifto]

Insulin -like growth factor 1 - IGF-1 LR3 - Information

IGF also mimic's insulin in the human body. It makes muscles more sensitive to insulin's effects, so if you are a person that currently uses insulin you can lower your dosage by a decent margin to achieve the same effects, and as mentioned IGF will keep the insulin from making you fat.

The most effective form of IGF is Long R3 IGF-1, it has been chemically altered and has had amino acid changes which cause it to avoid binding to proteins in the human body and allow it to have a much longer half life, around 20-30 hours. "Long R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substition of an Arg(R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. This analog of IGF-1 has been produced with the purpose of increasing the biological activity of the IGF peptide."
IGF Cycles

The most effective length for a cycle of IGF is 50 days on and 20-40 days off. The most controversy surrounding Long R3 IGF-1 is the effective dosage.

But it takes away the LBM positive effects IGF-1 has. Read up on Pinnacles thoughts on LR3 and Goose. They both know there stuff. As do many other Mods here. Your posting references to IGF-1, that works, but is very hard to obtain. Not LR3. There 2 different animals.

[Swifto]

Although the mechanisms underlying age associated muscle loss are not entirely understood, researchers attempted to moderate the loss by increasing the regenerative capacity of muscle. This involved the injection of a recombinant adeno-associated virus directing overexpression of insulin -like growth factor I (IGF-I) in differentiated muscle fibers.

They demonstrated that the IGF-I expression promotes an average increase of 15% in muscle mass and a 14% increase in strength in young adult mice (Figure 1), and remarkably, prevents aging-related muscle changes in old adult mice, resulting in a 27% increase in strength as compared with uninjected old muscles (Figure 2). Muscle mass and fiber type distributions were maintained at levels similar to those in young adults. These results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated.

Discussion:
I’m not sure where to begin. This study has the potential to completely change the way we age.

In this experiment, a recombinant adeno-associated virus, directing overexpression of insulin-like growth factor I (IGF-I) in mature muscle fibers, was injected into the muscles of mice. The DNA that was originally in the virus was removed along with markers that stimulate immune response. DNA coding for IGF-1 was then put into the virus along with a promoter gene to ensure high rates of transcription. The results, as you can see by figures 1 & 2, were dramatic.

IGF-1 plays a crucial role in muscle regeneration. IGF-1 stimulates both proliferation and differentiation of stem cells in an autocrine-paracrine manner, although it induces differentiation to a much greater degree. IGF-1, when injected locally, increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. The importance of IGF-1 lies in the fact that all of its apparent functions act to induce muscle growth with or without overload although it really shines as a growth promoter when combined with physical loading of the muscle.

IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.

The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.

The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.

The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.

In this study there was a preferential preservation of type IIb muscle fibers in aging mice. These are the fibers most sensitive to muscle hypertrophy from training and they are also the first fibers to disappear with aging. In the mice receiving the engineered virus, there was also a preservation of the motor neuron, leading to an increase in functional capacity. It is speculated that age related muscle loss is secondary to the loss of neuronal activation of type-II fibers. By preventing the degeneration of typ-II motor units, functional capacity could be maintained into old age. This technique may also serve useful in the prevention of osteoporosis. Further study is necessary to determine wether IGF-1 is having an effect only on muscle fibers or on nervous tissues as well.

Finally, it was also exciting to see muscle growth in the young mice who received the injection (15% increase in muscle mass). This means that the injection provided levels of IGF-1 far and above what the muscle normally has access to and not simply a preservation of normal levels. Remember that this was not combined with exercise. The growth of the injected muscles happened even without an extreme mechanical stimulus. The mice were simply allowed to run around as they usually do. Because of these dramatic results, the authors expressed concern about the use of this technique to enhance performance or cosmetic appearance. Research Update is not my personal soap box so I won’t go off on the gender centered hypocrisy of cosmetic enhancement in our society. All we can hope for is that this technique will be used to treat more important diseases such as muscular dystrophy and thereby become somewhat available for other uses as well.

I dont think YOU ate your breakfast this morning.

All this is on IGF-1, NOT LR3.

I'm not stating IGF-1 doesnt work, it does. I'm saying LR3 doesnt work and you have posted nothing but references supporting IGF-1 works, not LR3.

[higherdesire]

Well for everyone else, please feel free to read these refrences on IGF1-LR3 that are in every post except the last one, and additionally feel free to google it and read up for your self other sources besides this guy and me. Good luck

[myturn]

so can anyone answer the question i had reading? what high desire posted is well known what igf-1lr3 will do for muscle cells so i bump my question again to anyone that knows

[Swifto]

Well for everyone else, please feel free to read these refrences on IGF1-LR3 that are in every post except the last one, and additionally feel free to google it and read up for your self other sources besides this guy and me. Good luck

You need to do some more research and stop wasting your money on an overpriced GDA. Sorry to burst your ****ing bubble.

rIGF-1 is significantly different than LR3 IGF-1.
Gropep took rIGF-1 and broke the protein sequence to make LR3, which has a longer active life in cell cultures. Problem is, when gropep broke the protein sequence it rendered it useless as a muscle builder, and it's quite dangerous for humans to consume, hence the reason Gropep never put LR3 on the market.

LR3 added to what? IGF-1 was altered,nothing added. The protein chain/sequence was broken (altered).
Do you want me to explain how rIGF-1 works? You realize rIGF-1 mimics insulin in it disposes of blood glucose, right? rIGF-1 has nothing to do with lipolysis like some wildly make claim to. How it helps with in a diet is it disposes of blood glucose as to not allow any extra to be stored as fat.
When people see weight gain on LR3 it is water retention, and or coupled with increased glycogen storage. There is not one bit of evidence showing LR3 IGF-1 can cause increased muscle tissue. Not one piece, nor will there ever be. Gropep has shown LR3 has caused kidney damage (and death) in mice. That alone will stop any human testing.

You added 3 pounds of what using LR3? Water/fat/ increased glycogen uptake (again, see water).

Let me ask you this question:
The FDA approved rIGF-1 for adolescent growth disorders. Why is it the FDA has not conducted studies on LR3 if it supposedly(by some wishful thinking bodybuilders) a great drug for mass?
Could it possibly be the FDA has spoken with Gropep over any concerns they might have with LR3 IGF-1?
I spoke in depth with gropep in regards to LR3 several years back. I actually posted some( not all) the e mail correspondences right here on this very board

Next time you have any questions regarding a topic, you might not want to CALL someone out til you in fact know what YOU are talking about first.

Pinnacle

Define IGF-1...as in rIGF-1 that has clinical studies showing small increases of muscle mass, or LR3 IGF-1 that has zero clinical trails


LR3 has been shown in lab conditions, to be harmful in mice. Actually caused kidney failure. It showed some growth in mice. But what good is it if your a dead mouse? Further, human metabolism is significantly different than that of mice. It's foolish for anyone to say it will in fact work in humans, when science has shown countless times in lab conditions drugs that showed promise in animals had no bearing in human studies conducted. FACT! Any scientist will tell you that.

Bottom line is anyone who says LR3 has had muscle tissue growth has Zero clue about there body and are nothing more than dreamers...wishful thinkers if you will.

Pinnacle

With actual rIGF-1 and HGH this happens via satellite cells. No f*cking way with LR3 IGF-1. Not in humans....

Myself along with 2 friends ran multiple experiments that my endocrinologist oversaw. Ranging from frequent blood work done throughout every LR3 cycle, to hydrostatic testing conducting by my sports doctor.
Not one of us gained any muscle tissue on these experiments doses ranging from 60 mcgs per day to 200 mcgs per day.We all followed the same exact diets, and training protocol. Every one of us are competitive bodybuilders at national level, so we do know how to train , eat and know if something works or not. That's a big difference as opposed to some arm chair quarter back sitting on steroid .com all day saying " I think IGF is great". I say to that/those wishful thinkers. Post up pictures to show what you look like after all these great LR3 cycles. You'll never ever see these as*holes posting pictures because they are full of sh*t!

Pinnacle

But yeah...Keep using LR3 pal.

[marcus300]

Its not gains in LBM. IGF-1 LR3 will NOT yield gains in LBM. Its nothing but a very expeneive GDA. Your experiencing nothing more than water retention.



Again, LR3 wont put "1-2lbs" on you.

Its utter bullshit.

IGF-1 will, but I severly doubt you'll be able to get hold of real IGF-1.

Your doing nothing but burning a hole in your wallet.

No offence to both of you, but you need to read up on LR3.

I agree with swifto, back in the day I wasted £££'s on this rubbish, it isnt worth anything IMHO you are far better of using HGH what will if used correctly add some lean lbs

[goose]

This makes me sick,why the fuc do I spend my time on this piece of shit...I spent sevaral thousand on this crap.Fucing noobs.

igf1 lr3 made that way so it cannot bind to normal IGF1 carriers proteins like IGF1BP3, so it goes direct to receptors and has very short half life 10-20 minutes.

At this time, when IGF1 LR3 was developed, it was believed that after binding to IGF1BP3 IGF1 will become inactive. At present such concept proved to inaccurate, binding to IGF1BP3 did not inactivating IGF1, but in opposite prolonging it half life in circulation tremendously. Iplex for example already coming as a premix of rIGF1 and IGF1BP3.

IGF1 is a most abandon peptide in our body, in most tissues at any time we have huge amount of IGF1, so if you wonna see some results, your addition in form of injected IGF1 to endogenous IGF1 should be something significant to what we already have in circulation and it is about 6mg only in blood.
Gropep, who created LR3 IGF-1 knew that ,rIGF-1 works rather well,only one place sells that and your not going to get it (I can)
I have spoke to patrick arnold about this is his reply:

''LR3IGF-1 was primarily developed for use as an in-vitro growth stimulator for cultures. I don't think it was ever intended for use in animals or humans. If it was, there would be a patent. I never saw such a patent



I agree with you that its utility as an anabolic is quite low. It may have some benefit in connective tissue injury if injected directly



I am afraid you are mistaken on the fragility of rhIGF-1. It is no less unstable than other peptide hormones as long as its formulated correctly. look here, its even sold in a multi-dose vial''

Now you going to give me another piece of shit study???

[higherdesire]

You need to do some more research and stop wasting your money on an overpriced GDA. Sorry to burst your ****ing bubble.









But yeah...Keep using LR3 pal.

You flatter yourself way too much to think you are busting my bubble trick. Attack me if you want because I say I have results with it, and because I find other educated men that agree and post it. You digress little one.

[higherdesire]

What happend to my other post? Somebody not like the fact that I call you two out on being bad examples of handling this? It is a slippery slope gentleman, a slippery slope indeed.