Accutane effect on IGF1 and GH

[supe3]

I found this study and right away I thought everyone might want to take a look at it. I talks about the Isotretinoin (Accutane) and IGF1 and GH. If its been posted before then I am sorry.



Short-term isotretinoin treatment decreases insulin -like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology? Karadag AS, Ertugrul DT, Tutal E, Akin KO. Br J Dermatol. 2010 Apr;162(4):798-802. Epub 2010 Feb 1. Department of Dermatology, Keçiören Research and Training Hospital, 06290 Keçiören, Ankara, Turkey. [email protected]

BACKGROUND: Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treatment. OBJECTIVES: To analyse whether isotretinoin has any effects on insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP3) and GH levels. METHODS: Forty-seven patients aged 21.5 +/- 5.1 years (mean +/- SD) with acne vulgaris were included in this study. Isotretinoin therapy was initiated at a dose of 0.5-0.75 mg kg(-1) daily and then adjusted to 0.88 mg kg(-1) daily as maintenance dosage after 1 month. Screening for biochemical and hormonal parameters was performed just before initiation and after 3 months of isotretinoin treatment. RESULTS: IGF-1 and IGFBP3 levels decreased significantly after treatment (P < 0.01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P < 0.0001) while high-density lipoprotein cholesterol levels were significantly decreased (P < 0.0001). CONCLUSIONS: Isotretinoin therapy may have an effect on GH physiology, and further studies are needed to understand this association.

[ScotchGuard02]

I'm not a scientist and I don't pretend to be one. I just know that when I was on HGH and Accutane, the zits went away and I felt good. Not very scientific but it is data.