Time to take T4?

**Hondarocks** · 11-10-2011, 09:28 PM

Taking Pharma grade and i don't take stimulants, should I go down to 25ug?

**M302_Imola** · 11-11-2011, 06:53 AM

Originally Posted by Hondarocks

Any advice, starting to freak me out, was feeling great on the GH, now with the T-4 not so well. Should I get off it?

I wouldn't drop below 50mcg's unless you want to come off it all together. Anything that increase BMR can consequently increase anxiety, especially if you are prone to anxiety in the first place. My suggestion is to stay at 50mcg for a few more days and see if the sides subdue. Another idea is to take it a night before bed (if you are able to sleep on it) and hopefully you will sleep through the sides. I don't think the quality of your T4 is in question here as I know yours is pharma grade.

**Hondarocks** · 11-11-2011, 09:19 AM

Originally Posted by M302_Imola

I wouldn't drop below 50mcg's unless you want to come off it all together. Anything that increase BMR can consequently increase anxiety, especially if you are prone to anxiety in the first place. My suggestion is to stay at 50mcg for a few more days and see if the sides subdue. Another idea is to take it a night before bed (if you are able to sleep on it) and hopefully you will sleep through the sides. I don't think the quality of your T4 is in question here as I know yours is pharma grade.

Ok sounds good

**Hondarocks** · 11-11-2011, 07:01 PM

Ok well talked to a friend, and we know this stuff is defiantly working at 50ug. So I am good to go. Mind blowing energy at the gym!! But I feel spaced out all day as well.

**Hondarocks** · 11-14-2011, 04:04 PM

Man I feel like shit when I'm on the t-4 and like superman when I am just on the GH. What should I do?

**Hondarocks** · 11-14-2011, 05:02 PM

Im getting off the t4, its doing more harm than good. I talked to my roommate. He's says that he feels better on the t4 because he is already is hypo thyroid. And his family has a history of it. Since I don't have this and the t4 actually makes me go hyper thyroid I don't think I need it cause my thyroid is already high. I feel better without the t4 because it makes me have all the symptoms of hyper thyroid.

**SlimmerMe** · 11-14-2011, 05:38 PM

Gotta listen to your body.....

**Hondarocks** · 11-15-2011, 07:12 AM

Originally Posted by SlimmerMe

Gotta listen to your body.....

Good to go, I feel better already, I was taking 50mcg's a day for about 4 days. I just hope I didn't screw my perfect thyroid up!!

**Hondarocks** · 11-15-2011, 12:07 PM

Imola found this for me, This re affirms my convictions that I do not need t4.

"Originally Posted by BadGenCD"
Dat, do you need to use T3 or T4 when you take GHRP-6, as you do when you take exo GH, or no?
You don't need it for either GH or the GH releasers.
"GH increases circulating concentrations of T3 while decreasing those of T4. ...GH is not influencing the secretion of T3 and T4 but rather influencing peripheral 5- and/or 5' -monodeiodinase activity and the metabolism of the thyroid hormones and hence the conversion of T4 to T3 (the active form of the hormone)." - Growth Hormone , Stephen Harvey, CRC 1995, p.424
"Growth hormone treatment reduces T4 secretion and affects the peripheral metabolism of thyroid hormones resulting in an increase of T3..." - The effect of growth hormone on the plasma levels of T4, free-T4, T3, reverse T3 and TBG in hypopituitary patients, G. Gács, Acta Endocrinologica, Vol 96, Issue 4, 475-479
Keep in mind that most studies focus on people with under-performing thyroids so physiological supplementation has the effect of restoring GH release, while pharmacological doses do not illicit supernormal GH concentrations.

T3 may inhibit GHRH-induced GH release at the pituitary (multiple mechanisms) while T4 shouldn't have an inhibitory effect (i.e. it doesn't effect somatostatin).

So my opinion is that a normal person does not need thyroid supplementation w/ GH or GH releasers. That T3 supplementation may do more harm then good. If you feel the need to supplement with a thyroid hormone T4 would seem to provide more benefit.

**lovbyts** · 12-26-2011, 03:40 AM

Originally Posted by Hondarocks

Imola found this for me, This re affirms my convictions that I do not need t4.

"Originally Posted by BadGenCD"
Dat, do you need to use T3 or T4 when you take GHRP-6, as you do when you take exo GH, or no?
You don't need it for either GH or the GH releasers.
"GH increases circulating concentrations of T3 while decreasing those of T4. ...GH is not influencing the secretion of T3 and T4 but rather influencing peripheral 5- and/or 5' -monodeiodinase activity and the metabolism of the thyroid hormones and hence the conversion of T4 to T3 (the active form of the hormone)." - Growth Hormone , Stephen Harvey, CRC 1995, p.424
"Growth hormone treatment reduces T4 secretion and affects the peripheral metabolism of thyroid hormones resulting in an increase of T3..." - The effect of growth hormone on the plasma levels of T4, free-T4, T3, reverse T3 and TBG in hypopituitary patients, G. Gács, Acta Endocrinologica, Vol 96, Issue 4, 475-479
Keep in mind that most studies focus on people with under-performing thyroids so physiological supplementation has the effect of restoring GH release, while pharmacological doses do not illicit supernormal GH concentrations.

T3 may inhibit GHRH-induced GH release at the pituitary (multiple mechanisms) while T4 shouldn't have an inhibitory effect (i.e. it doesn't effect somatostatin).

So my opinion is that a normal person does not need thyroid supplementation w/ GH or GH releasers. That T3 supplementation may do more harm then good. If you feel the need to supplement with a thyroid hormone T4 would seem to provide more benefit.

Interesting information on T4