ALT-711 Thiazolium Chloride

[MUGG]

Anyone have any experience with ALT-711 Thiazolium Chloride?

[MUGG]

sorry posted this in wrong forum

[brazey]

Welcome...

[stpete]

Welcome anyway.

[AuSSie SpuDD]

G'day buddy

[Tigershark]

Welcome.

[spywizard]

welcome to the board..

google will give more data, but i have not come across it..



Alagebrium is no longer in development; however, many studies found benefits, such as the following data as summed up by Guo et al:

To investigate the possible effects of alagebrium chloride (ALT-711) on oxidative stress (OS) process in aging hearts, we examined the role of ALT-711 in cardiac function and OS in the heart of aging rats. Increased mitochondrial DNA (mtDNA) deletion as well as nearly a twofold increase in advanced glycation end products (AGEs) accumulation were observed in aging heart, whereas only about 50% of the superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities were seen. However, after treatment with ALT-711, preserved cardiac diastolic function accompanied with reduced mtDNA deletion and about 30% of AGEs decrease was observed in aging hearts. In addition, ALT-711 can increase SOD and GSH-PX activities in aging hearts as well as in cultured cardiomyocytes. In conclusion, our study suggests that AGEs accumulation and the abnormalities in the OS in aging hearts can be attenuated by ALT-711, and this might be a novel underlying mechanism for ALT-711 in the treatment of cardiovascular diseases that develop with aging.[1]

[Vettester]

Welcome to the various forums here at AR! As you get familiar with this site, please take a few minutes to review the Board Rules, which apply to ALL new and existing members: http://forums.steroid.com/showthread...S#.T4H7Xtnhe-A

Our Search Engine feature is a great way to easily locate specific topics and/or discussions pertaining to the topic(s) that are of interest to you. You can locate this feature at the top right section of the main forum page, or just simply click: http://forums.steroid.com/search.php...s#.T4H7wtnhe-A

Staff Members: http://forums.steroid.com/showgroups.php#.T4FDCNnhe-A
Feel free to contact myself or any of the staff members if you need help. We have a wealth of knowledge throughout this site, and we work closely as a TEAM, so please don’t hesitate to ask questions.

Don’t forget to review the “Stickies” at the top of each forum, as there’s a good chance that you will find a lot of your answers sitting within them.

Lastly, take notice of the features at the top of the forum page. You will find your Member Profile Page, which you can customize as you like. There’s also a Forum Actions link, which will drop down and allow you to interface with the Custom Settings of your profile. Note: You will need 50 posts prior to having the ability to Private Message another member … Just in case you’re wondering why that feature doesn’t quite work yet.

There’s much more, so please take your time to get accustomed to our site, and know that we are committed with helping you receive the knowledge needed to make informative and healthy decisions. We are glad that you joined!