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  1. #1
    Razzberry is offline New Member
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    Anyone Use SARM?

    They're tablets, and legal.

    http://endo.endojournals.org/cgi/con...en.2005-0572v1

    Endocrinology, doi:10.1210/en.2005-0572
    A more recent version of this article appeared on November 1, 2005

    Selective Androgen Receptor Modulator (SARM) Treatment Improves Muscle Strength and Body Composition, and Prevents Bone Loss in Orchidectomized Rats
    Wenqing Gao, Peter J. Reiser, Christopher C. Coss, Mitch A. Phelps, Jeffrey D. Kearbey, Duane D. Miller, and James T. Dalton*

    Division of Pharmaceutics, College of Pharmacy, Department of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210; Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN 38163

    * To whom correspondence should be addressed. E-mail:

    The partial agonist activity of a selective androgen receptor modulator (SARM) in the prostate was demonstrated in our previous study (Endocrinology 145(12):5420-28, 2004). In the current study, we characterized the full agonist activity of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (a structurally related SARM referred to in other publications and hereafter as S-4) in skeletal muscle, bone and pituitary of castrated male rats. Twelve weeks after castration, animals were treated with S-4 (3 or 10 mg/kg), dihydrotestosterone (DHT) (3 mg/kg), or vehicle for 8 weeks. S-4 (3 and 10 mg/kg) restored soleus muscle mass and strength and levator ani muscle mass to that seen in intact animals. Similar changes were also observed in DHT (3 mg/kg) treated animals. Compared with the anabolic effects observed in muscle, DHT (3 mg/kg) stimulated prostate and seminal vesicle weights over 2-fold greater than that observed in intact controls, while S-4 (3 mg/kg) returned these androgenic organs to only 16% and 17%, respectively, of the control levels. S-4 (3, 10 mg/kg) and DHT (3 mg/kg) restored castration-induced loss in lean body mass. Furthermore, S-4 treatment caused a significantly larger increase in total body bone mineral density (BMD) than DHT. S-4 (3 and 10 mg/kg) also demonstrated agonist activity in the pituitary, and significantly decreased plasma LH and FSH levels in castrated animals in a dose dependent manner. In summary, the strong anabolic effects of S-4 in skeletal muscle, bone, and pituitary were achieved with minimal pharmacologic effect in the prostate. The tissue selective pharmacologic activity of SARMs provides obvious advantages over steroidal androgen therapy and demonstrates the promising therapeutic utility that this new class of drugs may hold.

  2. #2
    NightWolf's Avatar
    NightWolf is offline Member
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    Ya i have used them, good stuff

  3. #3
    Gears's Avatar
    Gears is offline Member
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    If it's legal, where do you guys get this stuff?

  4. #4
    jnewton86's Avatar
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    what? i find it hard to believe this stuff is available to anyone at the moment. I know my people cant get any of it yet.

    if you've taken it, share your thoughts on it with us, how did it compare

  5. #5
    g0dsend's Avatar
    g0dsend is offline Member
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    It is avail, I received about 2 bottles of it about a month ago for my PCT.

  6. #6
    NightWolf's Avatar
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    Quote Originally Posted by jnewton86 View Post
    what? i find it hard to believe this stuff is available to anyone at the moment. I know my people cant get any of it yet.

    if you've taken it, share your thoughts on it with us, how did it compare

    What exactly do you want to know?
    IMO it does not compare to test in
    the ways of quik or big gains, you
    have to remember that this stuff
    does not give you water as test
    does so the gains are more quality.

    Also it does not shut down your HPTA
    or atleast i did not feel supressed in any way.
    Also IMO it takes a bit longer for this stuff
    to show its true effect, most guys have run this
    for 3-5 weeks, for me i was still seeing
    improvments in the mirror by the end of week 4.

    Also i did not feel anything with the libido until
    end of week 4, then it went thru the roof.

    Only side effect i feelt was the vision thing
    wich came in at week 2, when you enter
    a dark room its takes more time for your
    eyes to adjust.

    if anyone has questions about this stuff
    just ask and i will answer from my own experience.

  7. #7
    jnewton86's Avatar
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    interesting, i thought it would be awhile before anyone could get a hold of this stuff, thanks for your feedback man. not looking for anything specific, just wanted to see what you thought about it compared to test and others.

    thanx man

  8. #8
    NightWolf's Avatar
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    Forgot to add that i went up about
    5 lbs in those 4 weeks, wich is alot
    if you consider that there is no aromatize involved.

  9. #9
    Rugger02's Avatar
    Rugger02 is offline Anabolic Member
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    So no PCT? how long to you take it or do you cruise with it?

    Gotta be spendy don't it?

  10. #10
    NightWolf's Avatar
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    Quote Originally Posted by Rugger02 View Post
    So no PCT? how long to you take it or do you cruise with it?

    Gotta be spendy don't it?
    No PCT is needed, it whould
    be great for cruising.

    Actually its not so costly,
    look at it this way, you save money
    from the cost of

    Syringes (you drink it)
    PCT
    HCG

  11. #11
    briancb1 is offline Member
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    whats the name of the sarm? where is it available?

  12. #12
    Razzberry is offline New Member
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    SARM-X is one brand.

  13. #13
    Dog-Slime's Avatar
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    Quote Originally Posted by Razzberry View Post
    SARM-X is one brand.
    That is an herbal supplement and has nothing to do with the sarms being discussed here.

  14. #14
    Dog-Slime's Avatar
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    S4 is the only sarm I have seen around...

  15. #15
    ironaddict69's Avatar
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    Very interesting stuff. Just to be clear, are they prescription drugs? I have a hard time believing it is over the counter stuff...Will they be sold through research chem sites or what?

  16. #16
    Razzberry is offline New Member
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    Quote Originally Posted by Dog-Slime View Post
    That is an herbal supplement and has nothing to do with the sarms being discussed here.
    Sorry, you are correct.

    I just checked my bookmarked pages and that was DHEA along with something else.

    I do have the raw truth somewhere, and just need to find it. There was an amazing post on another forum that talked about a legal source (it's not really regulated AFAIK now) and the effects of a month of usage - yellow vision, things like that.

    The vision problems were very bizarre and pronounced, but other than that, no sides according to the man.

  17. #17
    bigD103 is offline New Member
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    so where exactly do u get this stuff...a posting or a pm would be great fellas

  18. #18
    Juice Authority is offline Knowledgeable Member
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    Quote Originally Posted by Gears View Post
    If it's legal, where do you guys get this stuff?

    To my knowledge there is only 1 distributor of SARMs (SARMs is still in clinical trials so its perfectly legal to possess before it eventually gets FDA approved and then controlled and likely scheduled). I love it. No bloat, incredible strength gains comparable to dbol , increased libido, and lean gains. The only downside IMO is vision blurriness but its manageable.

  19. #19
    Phate's Avatar
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    Quote Originally Posted by bigD103 View Post
    so where exactly do u get this stuff...a posting or a pm would be great fellas
    can't ask for sources bro, read the rules

  20. #20
    Severe is offline New Member
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    This stuff is seeming promising. I need to do a lot more research before I try it but so far so good.

  21. #21
    mr.scientist is offline New Member
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    links to more SARM research, lol MHP has a product called SARMs , S4 any more ppl know of?

  22. #22
    mr.scientist is offline New Member
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    From wikipedia

    None of the SARMs yet developed are truly selective for anabolic effects in muscle or bone tissues without producing any androgenic effects in tissues such as the prostate gland, however the compounds tested so far show a ratio of anabolic to androgenic effects of at least 3:1 and even up to as much as 10:1, whereas all known anabolic steroids have a ratio of around 1:1.[1][2][3]

    This suggests that while SARMs are likely to show some virilizing effects when used at high doses (e.g. recreational abuse by bodybuilders), at lower therapeutic doses they may well be effectively selective for anabolic effects, which will be important if SARMs are to have clinical application in the treatment of osteoporosis in women. One substantial advantage of even the first-generation SARMs developed to date is that they are all orally active without causing liver damage, whereas most anabolic steroids are not active orally and must be injected, and those anabolic steroids which are orally active tend to cause dose-dependent liver damage which can become life-threatening with excessive use. Research is continuing into more potent and selective SARMs, as well as optimising characteristics such as oral bioavailability and increased half-life in vivo, and seeing as the first tissue-selective SARMs were only demonstrated in 2003, the compounds tested so far represent only the first generation of SARMs and future development is likely to produce greatly superior agents compared to those available at present.
    sounds like everyone might be on these in the future, only thing I think might be a problem are the sides of eye sight, which would blow!

  23. #23
    smartbodybuilder is offline New Member
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    do u guys know when Gtx gona send Ostarine to the legal market?

  24. #24
    Rugger02's Avatar
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    Are the eye sight sides temporary, only while you're using?
    Do they go away immediately ceasing use?

  25. #25
    Dog-Slime's Avatar
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    Quote Originally Posted by Rugger02 View Post
    Are the eye sight sides temporary, only while you're using?
    Do they go away immediately ceasing use?
    Not speaking from experience but I have read of guys saying the vision problems go away quickly and are not permanent.

  26. #26
    ironaddict69's Avatar
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    More like, when the **** can we buy it and where?

  27. #27
    Deltasaurus's Avatar
    Deltasaurus is offline The Over Analyzing Nattabolic
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    yeah if its legal you can discuss it,

  28. #28
    AnabolicBoy1981 is offline Anabolic Member
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    The vision thing worries me. Im excited but at the same time a little cautious. Hell i thought cabergoline was the best thing ever....and then they find that it can cause heart valve growth. Even if it was at higher doses, studies are done with sedentary people, not people who test make their heart work all the time. NEW stuff must be dealt with carefully.
    Nolva and clomid, SERMS have both been shown to be cause ocular toxicity. Interesting these SARMS do the same thing. There must be a reason for this.

  29. #29
    0tolerance's Avatar
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    interesting quote i found on another website
    Despite how safe Ostarine is I'm absolutely certain it will be a scheduled drug by the time it is released which should be within a year or two. Either way GTx is certain to make a huge amount of money off of it. It is possible to buy Ostarine, however you have to buy it from GTx and you must be able to bluff you way through the process of buying it as someone with a legitimate research use. To say the least it is not easy to get your hands on any.

  30. #30
    Mr.TrX is offline New Member
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    wow you can buy this stuff at gnc no joke just saw it today

  31. #31
    Pac Man's Avatar
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    Quote Originally Posted by Mr.TrX View Post
    wow you can buy this stuff at gnc no joke just saw it today
    That would be Sarm X, just a knock off

  32. #32
    IM708's Avatar
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    Quote Originally Posted by Mr.TrX View Post
    wow you can buy this stuff at gnc no joke just saw it today
    no you can't

  33. #33
    NightWolf's Avatar
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    Quote Originally Posted by Rugger02 View Post
    Are the eye sight sides temporary, only while you're using?
    Do they go away immediately ceasing use?

    Yes for me they went away about 3 days after i stopped.

  34. #34
    kaisteel1 is offline New Member
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    Please read the rules before you post again.
    Big

  35. #35
    Phate's Avatar
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    Quote Originally Posted by kaisteel1 View Post


    I don't think this post should be a problem as they are still legal?
    ummmm....no, it is illegal, plus good luck with a source, most places i know you need a referral

    i should clarity my post, SARMs are not legal nor illegal really, as they are unscheduled yet, i was referring to your post being illegal on this forum

  36. #36
    Indymuscleguy's Avatar
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    I'd like to know more! Makes PCT sound more like a dream rather than a chore!

  37. #37
    Marinos is offline Junior Member
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    Does this need to be refrigerated or something? If I am able to find an overseas source, would it still be good to use by the time it was shipped to Australia?

  38. #38
    Phate's Avatar
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    Quote Originally Posted by Marinos View Post
    Does this need to be refrigerated or something? If I am able to find an overseas source, would it still be good to use by the time it was shipped to Australia?
    no to the refrigeration and yes to the other question

  39. #39
    chucklesmcgee is offline Junior Member
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    Quote Originally Posted by smartbodybuilder View Post
    do u guys know when Gtx gona send Ostarine to the legal market?
    Probably after positive phase III trials conclude and they submit the final paperwork. So maybe sometime in 2010-2011 you'll be able to get 3 mgs a day for grandma.

  40. #40
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    Quote Originally Posted by Phate View Post
    ummmm....no, it is illegal, plus good luck with a source, most places i know you need a referral

    i should clarity my post, SARMs are not legal nor illegal really, as they are unscheduled yet, i was referring to your post being illegal on this forum
    phate something is either legal or illegal. if i got caught with it i either get in trouble or i dont. if it isnt illegal then you could ask for a source. people ask for where to buy supplements and other products all the time and its allowed as long as its not illegal.

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