gdevine and kel's TRT Protocol

[hugovsilva]

Good catch! I meant Doxazosin.

Corrected my post.

Thank you

GD,

Any special reason for using a broad spectrum alpha blocker like Doxazosin instead of Tamsulosin, an alpha blocker with specific action in the urinary tract?

I leave you with an abstract that compares the action of both:

"Efficacy and safety of tamsulosin hydrochloride compared to
doxazosin in the treatment of Indonesian patients with lower
urinary tract symptoms due to benign prostatic hyperplasia
DJOKO RAHARDJO,
1
DODDY M SOEBADI,
2
SUWANDI SUGANDI,
3
PONCO BIROWO,
1
WAHJOE DJATI
2
AND IRFAN WAHYUDI
3
1
Subdivision of Urology, Department of Surgery University of Indonesia, Cipto Mangunkusumo Hospital,
Jakarta,
2
Department of Urology Airlangga University, Sutomo Hospital, Surabaya, and
3
Subdivision of Urology,
Department of Surgery Padjadjaran University, Hasan Sadikin Hospital, Bandung, Indonesia
Aim: The objective of the study was to compare the efficacy and safety of tamsulosin hydrochloride and doxazosin in patients
with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).
Methods: The safety and efficacy of tamsulosin (0.2 mg) and doxazosin (2 mg) was determined after once daily administration
for 6 weeks in an open-label, randomized, multicenter study of 101 men with BPH. The International Prostatic Symptom Score
(IPSS), maximal urinary flow rates (Qmax), average urinary flow rates (Qave) and residual urine were determined at baseline and
again at 6 weeks as efficacy parameters. The primary parameters used for safety evaluation were vital signs (blood pressure and
heart rate) and adverse events. The number of patients with a clinically significant response to treatment with tamsulosin or
doxazosin was determined and defined as those with >20% improvement from the baseline Qmax or >20% decrease in total IPSS.
Results: The total IPSS decreased significantly in both the tamsulosin and doxazosin groups compared to baseline. There was a
significant difference in the decrease in total IPSS between two groups. Qmax, Qave and residual urine significantly improved
only in the tamsulosin group. There were no significant differences in systolic blood pressure, diastolic blood pressure or heart
rate profile in the tamsulosin group; however, doxazosin resulted in a significant difference in systolic and diastolic blood pressure.
Tamsulosin was well tolerated; only three patients (6%) in the tamsulosin group reported an adverse event (dizziness) while 11
patients (22%) in the doxazosin group reported an adverse event (dizziness), one of whom withdrew from the study.
Conclusions: Tamsulosin was shown to be more effective than doxazosin in the treatment of LUTS due to BPH."