Pregnenolone & DHEA Supplementation

[steroid.com 1]

Read the stickies.

[Moparman]

Well let me rephrase. In the sticky for Hcg it says

DHEA Supplementation
Dehydroepiandrosterone: DHEA
As presented by Dr. Neal Rouzier, M.D.

Here's a great reason to add DHEA to your protcol.

DHEA is a hormone secreted primarily by the adrenal glands. It results in a shift of a catabolic state to an anabolic or protein building state.

 It reduces cardiovascular risks by increasing lipolyses (decrease visceral fat).
 It stimulates the immune system, restores sexual vitality, improves moods, decreases cholesterol and body fat.
 It improves memory, increases energy, and has anti-cancer properties by enhancing the immune system.
 It is an endocrine precursor to other hormones, prevents immuno-senescence, loss of sleep, osteoporosis, atherosclerosis.
 DHEA reduces insulin requirement
 Adrenal hormone anabolic vs. catabolic metabolism
 Restores immunity
 Prevents osteoporosis, increases bone density
 Prevents cancer in lab animals
 Prevents diabetes & heart disease
 Decreases visceral fat
 Improves mood & well-being
 Improves energy & memory
 Slows aging process in lab animals
 Prevents lipid peroxidation =
antioxidant
 Endocrine precursor to T.P.E.
 7-keto DHEA is not a precursor to other HRT = avoid
 Neurotransmitter (recently discovered)
 Presently pending FDA approval for Lupus (Prasterone)

Clinically substantiated uses of DHEA include replacement for:
 Low DHEA levels
 Chronic disease
 Adrenal exhaustion or corticosteroid therapy
 SLE
 Improving bone density
 Improving depression & mood disorders
 Enhancing immune response by activating T-cells
 Improving well-being
 Decreasing cardiovascular risk
 Improving erectile dysfunction
 Anyone over 40
 DHEA has never been shown to reverse the aging process
 Nevertheless DHEA is important for preventive medicine
 DHEA inhibits synthesis of thromboxane A2, reduces plasminogen activator inhibitor, and tissue plasminogen activator
– all decreasing platelet aggregation and ischemia.

Administraiton:
Men<200lb: 50mg AM
Men>200lb: 75-100mg AM

Women <50yo: 10-15mg AM
Women >50yo: 25mg AM

IMPORTANT:
DHEA Serum Levels
 MEN
 Range 100-600
 Optimal 500-600
WOMEN
 Range 50-300
 Optimal 200-250

Higher levels in women predispose them to side effects – therefore stay low
 Monitor monthly until optimal
 Assure correct dose and compliance
 Measure DHEA-S and not DHEA

 Side effects: acne, hirsutism
 Tx: Lower dose or take QOD Spironolactone 100 mg/day
 Contraindicated in sex hormone responsive tumors – breast, ovarian, uterine, prostate
 Conversion to T.P.E.?
 DHEA raises testosterone levels in women slightly, yet not in men
 DHEA raises estradiol slightly in men

Indications:
 Over age 40 for health protection
 Preventive medicine and well-being
 Symptoms of aging, mood & depression
 ‘Cause the medical literature suggests it if we want to live longer, happier, healthier

DHEA – S04
 MEN Blood levels
 Optimal : 500-600 ug/ml
 Side effects rare in men
WOMEN
 Optimal : 200-250 ug/ml
 Dose based on side effects
 Side effects very common in women

DHEA Dose
 MEN
 Capsule – SR micronized
 50 mg Q am
 >200 lbs – 75 - 100 mg Q am

WOMEN
 Capsule – SR micronized
 10 mg Q am if over 40
 15 mg Q am if over 50
 25 mg Q am if over 60
 If under age 40, do not prescribe due to sensitivity causing side effects.

Are these effects due to the testosterone increase? Would we benefit from taking the Dhea suppliment while on test cyp?

[steroid.com 1]

Yes, back fills the pathways.

[Mr Tick]

Never really heard about supplementing both.

Im 29 and on TRT at 60mg 2X a week, HCG 200iu 2X a week and i take .05mg letrozole once a week. My doc told me to start taking pregnenolone at 100mg once a day. He had never mentioned anything about supplementing DHEA. My last bloodwork for DHEA was a while back. It came in at 191 with a range of 160-449.

I am due to go back in another month and a half for prescription refills and blood work. Should I start taking some DHEA with the pregnenolone and get the bloodwork done in about 8 weeks? Or would it be better off to just take the pregnenolone and ask about the DHEA when i go in?

[steroid.com 1]

^^^^Read the Sticky on HCG and Pregnenolone there is good info in there on DHEA.

[Mr Tick]

I have read once already. I guess I needed to read it again. I see that I must of missed a few things. I was in a little bit of a hurry. Ty for the sticky. I'm going to supplement both and just get both levels checked in 8 weeks. I have read where most people are taking 50mg split in 2 does of the dhea as well as the progesterone.
My doc told me to take it at 100mg per day. Is this common?

[steroid.com 1]

Pregnenolone best at 50 mg of a slow release micronized pill once daily in the am.

DHEA 25 mg twice daily of a slow release micronized pill.

[FRDave]

Pregnenolone best at 50 mg of a slow release micronized pill once daily in the am.

DHEA 25 mg twice daily of a slow release micronized pill.

If taking 100mg Pregnenolone, would it be best to still take one daily dose in the AM or should we take 50mg twice daily like DHEA?

I am assuming Pregnenolone can aromatise into Estrogen like DHEA if taken in large amounts?

Thanks in advance,
Dave

[ozley62]

I've been taking 50 mg of Pregnenolone every morning for a few weeks, I noticed my sleep has improved a lot. But I'm either topped out on DHEA or highly allergic to it, my face, neck and shoulders turn blood red and I'll sweat my ass off when I take 25 mg, no matter if it's cheap or the expensive micronized. I won't touch DHEA again!

[steroid.com 1]

If taking 100mg Pregnenolone, would it be best to still take one daily dose in the AM or should we take 50mg twice daily like DHEA?

You can take Preg all at one time but spitting it is nice because it gives you a nice steady serum level throughout the day.

I am assuming Pregnenolone can aromatise into Estrogen like DHEA if taken in large amounts?

Correct, as noted in large amounts 50 to 100 mg are not in anyway large dosages.

Thanks in advance,
Dave

Bold.

[FRDave]

Bold.

I was just about to order more as I am almost out... Do you think I should up my intake to 150 mg (75mg twice daily - can break tab in half) vs the 100mg I am currently taking (Nutricology micronized)?

My blood work came back at 62 ng/dL on a scale of 13-208 ng/dL, however, blood work was taken about 24hrs after last intake (took Friday morning at 7am and got blood work at 9am on Saturday morning fasting).

Thanks again,
Dave

[steroid.com 1]

^^^^I'd stick with the 100 mg split twice daily.

Both of these hormones are best taken in small doses so please note that.

[MickeyKnox]

They're here...ordered Monday arrived on Thursday! As expected, pharmacy grade, ultra pure and ultra micornized (whatever that means over micronized LOL).

As I said, for me, these are cheaper than what my compounding pharmacy charged for both under prescription yet the same from a formulation standpoint

Where it comes to my TRT meds, I don't care about cost, I care about quality and effectiveness and when the best TRT Doc's recommend it for their patients I am good with that.

Again, that's just me.

Attachment 135181

True to my word, here is my order of the same as GD.

Note: the tabs have been removed from original bottles and vacuumed packed, in order to be mailed to Canada and pass through the boh dah.

I removed them form their vacuum seal and placed them into containers i already had on hand. Then i carefully peeled of the stickers that were affixed to the packaging, and stuck them on my bottles.

Thanks again for all your help GD - much appreciated.

[darkmatter22]

Thanks GD I followed your advice regarding the dhea and pregnenolone and just got mine today. It took a week but Im glad i got a quality product, Im also thankful for the education on supplements an other information regarding TRT you have given me- I would have just gotten the cheap stuff at GNC or something but now I understand why pharmacy grade is worth the $ an the wait!

Im going to do - 50mg pregnenolone in the a.m and one 25mg of dhea in the a.m followed by another in the pm around 8 hours later.. correct?

[steroid.com 1]

Yes, these products are the real deal, pure and pharmacy grade not discounting ultra micronized for better uptake.

I take 25 mg of the DHEA before bed and one when I wake. These are slow release so you won't get that energized feeling some men get.

I take 50 mg of preg when I wake as well.

Keep an eye on inventory and know when to order in advance so you don't run out.

[ozley62]

Have you ever heard of a connection between lack of Pregnenolone and migraine headaches? I started taking Anastrozole a few months back because after 3 years of being on TRT I finally got a dr. to check my E2 levels and they were high, tatal E was over 300 and E2 over a 100. Before I started the Anastrozole I suffered from severe migraines daily and they went away shortly after I started taking it. So I was convinced that was what was causing the migraines. I also started taking Pregnenolone about the same time. I ran out of Pregnenolone and was without for a little over a week and the migraines came back BIGTIME! When I started taking the Pregnenolone again the migraines have not come back. I know headaches can be caused by high E2, but it looks like being low on Pregnenolone can cause it too.

[austinite]

Thanks GD I followed your advice regarding the dhea and pregnenolone and just got mine today. It took a week but Im glad i got a quality product, Im also thankful for the education on supplements an other information regarding TRT you have given me- I would have just gotten the cheap stuff at GNC or something but now I understand why pharmacy grade is worth the $ an the wait!

Im going to do - 50mg pregnenolone in the a.m and one 25mg of dhea in the a.m followed by another in the pm around 8 hours later.. correct?

I just switched to those. Didnt realize they are out of houston, package arrived the next day.

[steroid.com 1]

Thanks GD I followed your advice regarding the dhea and pregnenolone and just got mine today. It took a week but Im glad i got a quality product, Im also thankful for the education on supplements an other information regarding TRT you have given me- I would have just gotten the cheap stuff at GNC or something but now I understand why pharmacy grade is worth the $ an the wait!

Im going to do - 50mg pregnenolone in the a.m and one 25mg of dhea in the a.m followed by another in the pm around 8 hours later.. correct?

Correct.

[GeriatricOne]

Question: If HCG promotes pregnenolone production (per the HCG and Pregnenolone sticky) and HCG is part of one's protocol, why supplement with additional pregnenolone?

[steroid.com 1]

Question: If HCG promotes pregnenolone production (per the HCG and Pregnenolone sticky) and HCG is part of one's protocol, why supplement with additional pregnenolone?

Simple, the doses we are taking when and what becomes from a bio-available is very low. So by covering all the bases at low doses insures we are doing our best to back fill the pathways as best we can.

Also, Preg and DHEA support other critical hormonal pathways (think mineralcorticoids and corticosterioids) beyond just the Androgen pathway...so it's important to make sure they are at the optimal levels.

It's not a one trick pony unfortunately.

[mikey1979]

My doctor recommended I start taking both DHEA and Pregnenolone as part of my TRT supplementation and I bought DHEA from the local GNC because I didn't think that their was a actual pharmaceutical grade product..

I couldn't locate the pregnenolone, so when I went to the compounding pharmacy that my doctor office is located inside they compounded it and I ended up with a script.

Do you think they can do that with the DHEA?

Also I'm getting HCG prescribed but the pharmacy said they can't get the usual brands! They compounded it into a multi-dose vile so it doesn't need to be mixed or refrigerated according to the pharmacist.

This struck me as odd as I have never heard of this.. I was told to take 500IU 3 times weekly. I am a little Leary of the HCG and I want children so it is important that I'm getting real quality medication.

Is there any way to test the HCG to make sure it is real?