I started TRT a few months ago, but crashed my E2 pretty hard (thanks to GD for spotting this). Not a fun place to be: super anxiety/panic attacks, zero libido, fatigue, etc. I have not taken an AI in about 2 weeks and was feeling like I was getting a little bloaty and thought my E2 levels might be creeping high.

I took .25 mg Arimidex today and within about 2 hours starting feeling like hell. (i.e. exhausted, brain fog, apathetic).

I was wondering if folks could comment on how quickly you feel the effects of taking an AI and also subjectively how this made you feel? If you were high E2, I'd suspect the AI would probably make you feel better. If you were already low, my guess is that you'd start to feel pretty lousy (like I experienced today).