Help with Methylcobalamin (B12) injections

[100%]

pm sent

[austinite]

How administered

Methylcobalamin injections are typically given once per week for 10 weeks to restore deficient levels. Methylcobalamin can be administered by subceutaneous and intramusclular injection.

Common Protocol: Inject 1-2mL of Methylcobalamin Intramuscular (IM) once per week for 10 weeks, then once every 30 days to maintain levels.

*Note : larger amounts of methylcobalamin are necessary to correct neurological defects and protect against aging

Injection vs Oral

Absorption of methylcobalamin is optimal with an injection compared to oral administration, and therefore less frequent injections are needed once blood levels of B12 reach an acceptable level.

Research study

Oral supplements of vitamin B12 appear to correct vitamin B12 deficiencies as well as B12 injections. However, in order to correct a deficiency, oral doses need to contain more than 200 times the recommended daily allowance (RDA) of vitamin B12. Study author Dr. Lisette C. P. G. M. de Groot of Wageningen University in the Netherlands explained that most people develop vitamin B12 deficiencies as a result of "malabsorption," in which their bodies become unable to extract vitamin B12 from food. The deficiency typically strikes older people, she added, and takes years to develop. In some instances, people who avoid animal products -- such as vegans and followers of a macrobiotic diet -- can also develop a deficiency in vitamin B12 as a result of not eating enough B12-rich foods. A vitamin B12 deficiency is typically treated by monthly, often painful, shots. To investigate whether an oral dose of vitamin B12 works, as well, they tested various daily doses of oral vitamin B12 supplements in 120 people aged 70 and older. They found that daily oral doses of 647 to 1032 micrograms of vitamin B12 appeared to correct the deficiency. The current RDA for vitamin B12 is 3 micrograms per day. Archives of Internal Medicine, May 23, 2005.

Side Effects:

Irritation at the injection site and/or skin rash have been reported by some patients.

ok. 'Some patients' doesnt really tell us much and is not subQ specific. Considering how many people are prescribed B12, sounds like a drop in the bucket. I hate to steer people away because of a few experiences. Either way, delivery method does not matter. So long as you get your B12

[100%]

ok. 'Some patients' doesnt really tell us much and is not subQ specific. Considering how many people are prescribed B12, sounds like a drop in the bucket. I hate to steer people away because of a few experiences. Either way, delivery method does not matter. So long as you get your B12

Just to make things clear for everyone I am talking only about the original posters b12 pic references are referring to this brand only as noted in my post first pic.

[austinite]

Just to make things clear for everyone I am talking only about the original posters b12 pic references are referring to this brand only as noted in my post first pic.

Yes, sorry I missed that in your initial reference.

[HRTstudent]

Is there anyone out there injecting B12 only subQ with labs?

this information wouldn't tell you anything...

b12 injected is just extra b12. people get varying amounts of b12 through their diet.

[powerlifterty16]

Here you go.

that says cyano..you should switch to methylcobalmin

[100%]

I saved this response from lowtmike on another thread as I found it very interesting. He does say IM but maybe he can chime in on weather it matters. "There is no toxic level of B-12. Imposible to overdose. Mine personally is in the 4,000s and I like to keep it there. Many lab tests go over 1500. The best form of bioavailble B-12 is an injectable form called methylcobalamin. B-12 you have to store it in the liver before you use it. Thats what the B-12 panel picks up (B-12 liver marker) Methyl ester when you do a IM injection pushes the B-12 pass the Liver (going around the first pass) and directly into the blood stream. Just because you liver shows high absorption. You can still be having Chronic Fatigue Syndromw and malabsoprtion of B-12. This is why oral or sub-ligual drops or tablets of b-12 dont work for many, Even the oral methyl. Your body still has to pull the b-12 out of the large intestine. Most americans because of our diet have matted villa and flora in our guts and cant make or absorb B-12. Injectable Methylcobalamin is the best form B-12 directly into blood stream, pass the liver and then bioavailabe. It just makes since and Ive been using for years in patients and they love it as part of there TRT."

[austinite]

that says cyano..you should switch to methylcobalmin

Yeah that was cyan, I was merely showing the subQ statement. I have methyl on the way, powder, will make injectible. Been using methyl for a while.

[fm2002]

this information wouldn't tell you anything...

b12 injected is just extra b12. people get varying amounts of b12 through their diet.

I'm not sure I understand what you're saying? Are saying if one injects B12 subQ it won't show up on a blood test?

[austinite]

I'm not sure I understand what you're saying? Are saying if one injects B12 subQ it won't show up on a blood test?

No. He is saying comparing to someone elses blood work would not be relevant. Which is correct.

[fm2002]

So say if someone that has a baseline blood test before they start B12. Than starts B12 subQ injections. Gets a blood test say 6 weeks down the road. Whatever the results; there not relevant?

Of course everybody's body will react differently, but to say anyone who has their blood tested before and periodically along the way and the results aren't relevant; I'm just not getting that?

Except for a few exceptions, truth is in the blood.

[austinite]

So say if someone that has a baseline blood test before they start B12. Than starts B12 subQ injections. Gets a blood test say 6 weeks down the road. Whatever the results; there not relevant?

Of course everybody's body will react differently, but to say anyone who has their blood tested before and periodically along the way and the results aren't relevant; I'm just not getting that?

Except for a few exceptions, truth is in the blood.

Well, take a look at testosterone . Some gel users get up in the 800+ng/dl. Some do not respond at all. My injection protocol takes me to 750. There's just no way for you to compare. Same with B12. Even more difficult actually because you get it from food, too.

Some deficient folks can get in range with orals. Others have to inject. So you will not benefit from looking at someone elses blood work. Everyone's binding capacity varies. This one is just way way way too broad.

[fm2002]

Kind of thought one of the great things about forums like these is to be able to compare results. What you're saying at least in regards to B12 and Testosterone is the only relevant results are your own.

Not sure I agree with that but, ok. Think I belabored the point enough.

[austinite]

Kind of thought one of the great things about forums like these is to be able to compare results. What you're saying at least in regards to B12 and Testosterone is the only relevant results are your own.

Not sure I agree with that but, ok. Think I belabored the point enough.

Alright. Well here you go...

Prior to using B12 cyan @ 1000mcg /week B12 was at 202.

Below is after 4 weeks..




Below is after another 4 weeks...

[HRTstudent]

So say if someone that has a baseline blood test before they start B12. Than starts B12 subQ injections. Gets a blood test say 6 weeks down the road. Whatever the results; there not relevant?

Of course everybody's body will react differently, but to say anyone who has their blood tested before and periodically along the way and the results aren't relevant; I'm just not getting that?

Except for a few exceptions, truth is in the blood.

I really was getting at the point that it doesn't matter so much how other people's b12 compare to your own.

Of course if you took b12 injections you would want to monitor your levels, and the effect that has on your body is very relevant to yourself. But it won't really tell any random person what their b12 is or help them figure it out.

I recommend b12 injections if your level is low and definitely get follow up blood work to make sure you are taking the right dose. B12 injections are generally very safe, well tolerated, and very effective at what they do. Low b12 and all the negative long term effects of this are very avoidable for anyone in a developed country IMO.

[fm2002]

Amen about B12. I just hate having to take it IM. As mentioned I will be the happiest camper if I don't have to do any IM's anymore and the B12 is the only one I do IM. All I'm trying to get at is if B12 injections subQ are effective. To convince me would be if somebody had a baseline blood test before and than blood test after showing the amount they used and a significant rise. Do I expect someone to come forth. No, but it would be nice. I'll probably be the guinea pig myself?

There's another popular thread on this sub forum about the effectiveness of subQ Testosterone where they are asking for only labs to back it up. The same for determining the difference of fake and real HGH. The truth is in the blood. Posting labs, comparing labs, critiquing labs is an incredible tool and should not be underestimated !

@Austinite - thank you for posting your labs ! I think you said you're doing both IM & subQ B12 injections. If so your labs to determine subQ effectiveness would be irrelevant. Side note; your Estradiol looks a bit high

[austinite]

Amen about B12. I just hate having to take it IM. As mentioned I will be the happiest camper if I don't have to do any IM's anymore and the B12 is the only one I do IM. All I'm trying to get at is if B12 injections subQ are effective. To convince me would be if somebody had a baseline blood test before and than blood test after showing the amount they used and a significant rise. Do I expect someone to come forth. No, but it would be nice. I'll probably be the guinea pig myself?

There's another popular thread on this sub forum about the effectiveness of subQ Testosterone where they are asking for only labs to back it up. The same for determining the difference of fake and real HGH. The truth is in the blood. Posting labs, comparing labs, critiquing labs is an incredible tool and should not be underestimated !

@Austinite - thank you for posting your labs ! I think you said you're doing both IM & subQ B12 injections. If so your labs to determine subQ effectiveness would be irrelevant. Side note; your Estradiol looks a bit high

E2 is fine. but lol, after all that discussion about labs and now you say it's irrelevant ? LOL!

[LowT Mike]

IM methlycobalamin is the best. If you dont have a true B-12 malabsorption issue...just taking for chronic fatigue and to boost energy. doses of 200mcg-400mcg per week is a good regime. 1000mcg per week or 1 full cc would be if you absouluty had no intrinsic factor to make or store B-12 anymore. Always talk to your doc and get levels done.

[fm2002]

E2 is fine. but lol, after all that discussion about labs and now you say it's irrelevant ? LOL!

Yeah I know. Almost didn't want to add that, but because you're doing both IM & subQ you can't single out subQ.

[austinite]

Yeah I know. Almost didn't want to add that, but because you're doing both IM & subQ you can't single out subQ.

You're not going to find anyone, on any forum.. that can give you bloodwork for a subQ comparison.

[HRTstudent]

Amen about B12. I just hate having to take it IM. As mentioned I will be the happiest camper if I don't have to do any IM's anymore and the B12 is the only one I do IM. All I'm trying to get at is if B12 injections subQ are effective. To convince me would be if somebody had a baseline blood test before and than blood test after showing the amount they used and a significant rise. Do I expect someone to come forth. No, but it would be nice. I'll probably be the guinea pig myself?

There's another popular thread on this sub forum about the effectiveness of subQ Testosterone where they are asking for only labs to back it up. The same for determining the difference of fake and real HGH. The truth is in the blood. Posting labs, comparing labs, critiquing labs is an incredible tool and should not be underestimated !

@Austinite - thank you for posting your labs ! I think you said you're doing both IM & subQ B12 injections. If so your labs to determine subQ effectiveness would be irrelevant. Side note; your Estradiol looks a bit high

I don't know of anyone that posted about specifically subQ compared to intramuscular b12. likewise, comparisons would be more difficult than testosterone because testosterone levels are 100% reflective of what you inject but that is far from the case in b12. it's never mentioned really but there are certainly people who do both varieties... there's no reason to doubt the efficacy of b12 subq IMO. it should prove to be a rather harmless test if you wish though.

[fm2002]

I don't know of anyone that posted about specifically subQ compared to intramuscular b12. likewise, comparisons would be more difficult than testosterone because testosterone levels are 100% reflective of what you inject but that is far from the case in b12. it's never mentioned really but there are certainly people who do both varieties... there's no reason to doubt the efficacy of b12 subq IMO. it should prove to be a rather harmless test if you wish though.

You can definitely see the effectiveness of IM B12 injections in my blood tests. They went from 390 to 1230 on 1000mcg every 10th day (no food intake is going to do that) and than when I adjusted down to 500mcg every 10th day it went to 808. Exactly what you'd expect.

Now am I missing something here. I mean is there some reason B12 subQ will not show up on a blood test like it did above for IM ???

I may try it myself. If I do I surely post my results.

[austinite]

You can definitely see the effectiveness of IM B12 injections in my blood tests. They went from 390 to 1230 on 1000mcg every 10th day (no food intake is going to do that) and than when I adjusted down to 500mcg every 10th day it went to 808. Exactly what you'd expect.

Now am I missing something here. I mean is there some reason B12 subQ will not show up on a blood test like it did above for IM ???

I may try it myself. If I do I surely post my results.

There you go - Those will be the only numbers that will matter to you. You won't notice a difference in B12 levels whether you go IM or subQ.

[powerlifterty16]

i really dont understand why u guys want to pin b12....the sublinguals are so effective and i feel so much better when i take them

[austinite]

i really dont understand why u guys want to pin b12....the sublinguals are so effective and i feel so much better when i take them

Sublinguals will get you in range if you're slightly deficient. They will not get you to optimum levels. Plenty of studies available.

[powerlifterty16]

Sublinguals will get you in range if you're slightly deficient. They will not get you to optimum levels. Plenty of studies available.

sorry man but that's not correct...my levels cant even be measured they are above range >1500.
Ive seen studies that say the opposite as well.

I take 5k mcg of jarrow mb12.

[austinite]

sorry man but that's not correct...my levels cant even be measured they are above range >1500.
Ive seen studies that say the opposite as well.

I take 5k mcg of jarrow mb12.

I've posted several studies in the supplement section. Can you cite one study showing sublingual effectiveness to be as high as injectable?

I also used Jarrow Methyl, great sublingual.

[HRTstudent]

i really dont understand why u guys want to pin b12....the sublinguals are so effective and i feel so much better when i take them

some people cannot utilize the supplements... but b12 shots are inexpensive and effective so it's an obvious treatment option. you also have the compliance/convenience factor, which cannot be ignored. many people "cannot" take a pill every day, but they could do an injection once every week or two.

[powerlifterty16]

I've posted several studies in the supplement section. Can you cite one study showing sublingual effectiveness to be as high as injectable?

I also used Jarrow Methyl, great sublingual.

with all due respect, i dont agree with you this one sadly. what study do i need other than my blood work? How can you disagree that it's gotten me to optimal?
I saw a few studies many years ago(ive been taking this for years)...too lazy to find them again.

[powerlifterty16]

some people cannot utilize the supplements... but b12 shots are inexpensive and effective so it's an obvious treatment option. you also have the compliance/convenience factor, which cannot be ignored. many people "cannot" take a pill every day, but they could do an injection once every week or two.

id be lost without my lozenges. i take it when iwake up and feel tired/have no appetite and as im sucking on it my symptoms dissapear...it has been remarkable for me...tastes good too

[austinite]

with all due respect, i dont agree with you this one sadly. what study do i need other than my blood work? How can you disagree that it's gotten me to optimal?
I saw a few studies many years ago(ive been taking this for years)...too lazy to find them again.

I don't disagree completely. It's possible, but very rare. And most certainly not possible with reasonable dosages. The majority of people have some level of digestive issues. Most don't know it. Theres little to compare. Remember also,, your sublinguals are 5000 mcg and taken daily (usually), injecting 500 to 1000mcg once per week would yield better results. Not to mention a 5000mcg sublingual takes over 20 minutes to dissolve.

Every single study that has ever done a comparison, concluded that oral administration was good enough to get patients out of deficiency. I've researched this heavily. PUBMED has just over 120 articles on this topic, I've been through all of them because I wanted to do this without injections. Found nothing to support equality.

Anyway, it doesn't matter. If something is working then that's all that matters. We can agree to disagree on this one.

[powerlifterty16]

I don't disagree completely. It's possible, but very rare. And most certainly not possible with reasonable dosages. The majority of people have some level of digestive issues. Most don't know it. Theres little to compare. Remember also,, your sublinguals are 5000 mcg and taken daily (usually), injecting 500 to 1000mcg once per week would yield better results. Not to mention a 5000mcg sublingual takes over 20 minutes to dissolve.

Every single study that has ever done a comparison, concluded that oral administration was good enough to get patients out of deficiency. I've researched this heavily. PUBMED has just over 120 articles on this topic, I've been through all of them because I wanted to do this without injections. Found nothing to support equality.

Anyway, it doesn't matter. If something is working then that's all that matters. We can agree to disagree on this one.

yup let's agree to disagree. my blood work doesnt lie . Like i said ienjoy the 20 minutes of sublingual dissolving. It is like a candy . I was shocked by my labs...they couldnt even measure me!
i used to post on a forum called phoenix rising(it's a chronic fatigue forum)...and all the members had similar results to me. Brand is important. Jarrow is considered the best of the best along with enzymatic therapy.

[austinite]

yup let's agree to disagree. my blood work doesnt lie . Like i said ienjoy the 20 minutes of sublingual dissolving. It is like a candy . I was shocked by my labs...they couldnt even measure me!
i used to post on a forum called phoenix rising(it's a chronic fatigue forum)...and all the members had similar results to me. Brand is important. Jarrow is considered the best of the best along with enzymatic therapy.

Maybe you can post your results someday. I'm aware of phoenix forums. The sticky threads there support what I say. They even recommend 2 doses of jarrow for results.

[powerlifterty16]

i posted my bloodwork a while back. the b12 was >1500..wouldnt give me a number because it was out of measurable range.

i used to take 10-15k of the jarrow but it was overkill even 5k has been helping me. You need to remember that a lot of people on that forum are not in good health....and dont workout.

[SexySweetheart]

I have only had injects at the ER for my deficiency - currently take prescription level pills ~ this was an interesting thread.
I can not help but wounder how defiant one must be to get the shot prescribed rather that pills? the pills are cheep as hell for me and I am super deficient (to the point of black outs/pass outs in combination with my hypoglycemia due to my bodies malaborbtion after a surgery).

tnatious best of luck to you

[austinite]

^ That's the point exactly. Pills are perfect to get you to an acceptable level. They do work in that aspect. If your level is 180, you're deficient. But you only need to get to 200. Easy to do with pills.

[SexySweetheart]

^ That's the point exactly. Pills are perfect to get you to an acceptable level. They do work in that aspect. If your level is 180, you're deficient. But you only need to get to 200. Easy to do with pills.

lol ok the med gar-gin was confusing me and for a min I was concerned as to if i should be asking my dr for shots instead of pills ~ relieved now at times I have fainting even on my pills but Im the exception -due to an intestinal surgery that resulted in bypassing a huge part of my intestine-so i process food/ vite /min different than the average bear


i dont know about the op but if i had to choose between shooting myself or popping a pill~ the pill wins every time

[austinite]

i posted my bloodwork a while back. the b12 was >1500..wouldnt give me a number because it was out of measurable range.

i used to take 10-15k of the jarrow but it was overkill even 5k has been helping me. You need to remember that a lot of people on that forum are not in good health....and dont workout.

Ok. Because on the 4th of April you said you never tested your B12 levels. You said you'd post them in may when you get tested, cant seem to find them anywhere. Might be just blind.

There is no toxic level of B-12. Imposible to overdose. Mine personally is in the 4,000s and I like to keep it there. Many lab tests go over 1500. The best form of bioavailble B-12 is an injectable form called methylcobalamin. B-12 you have to store it in the liver before you use it. Thats what the B-12 panel picks up (B-12 liver marker) Methyl ester when you do a IM injection pushes the B-12 pass the Liver (going around the first pass) and directly into the blood stream. Just because you liver shows high absorption. You can still be having Chronic Fatigue Syndromw and malabsoprtion of B-12. This is why oral or sub-ligual drops or tablets of b-12 dont work for many, Even the oral methyl. Your body still has to pull the b-12 out of the large intestine. Most americans because of our diet have matted villa and flora in our guts and cant make or absorb B-12. Injectable Methylcobalamin is the best form B-12 directly into blood stream, pass the liver and then bioavailabe. It just makes since and Ive been using for years in patients and they love it as part of there TRT.

^ This is from a board certified member that is light years ahead of both you and me in both experience and knowledge. I'll take his word for it.

[powerlifterty16]

not to bash you or mike, but the only knowledge i need is my own blood work, and what alleviates my symptoms. if i came at you with 5 studies right now telling you that test cyp doesnt raise t levels...youd prob say ''eff you'' because you know it works for you.

this is really odd but i dont see my old thread where i posted my b12 bloodwork.i got my b12 checked after my urology consult..i believe it was end of April beginning of may....but like i said it was greater than 1500...even in my old thread i just typed out the results didnt scan them in...so if you think im lying...i was lying then too...not trying to put word in your mouth as i respect your opinion as well...but is the reason you want o see that thread because you're thinking im lying about my results?

[THINKBIG]

I have only ever used B12 subQ with results always in the high end of scale and I have also used Test Cyp and Test E SubQ for almost a year with no difference in my bloodwork compared to IM injections.