When I was doing my M1T/4ad cycle i would split up the time i took the dosage, ever 12 hours. And then I would take my milk thristle, NAC, Hawthrone Berry and Multi Vitamins at different times throughout the day because I didnt like having so many pills in my stomache at the same time. Ending up working out great, having a constant dosage of the M1T in your blood stream all the time was pretty intense.