*Aromasin (Exemestane) vs Arimidex (Anastrozole) Unraveled*

[600@50]

Another great post MK. Thanks man.

[MickeyKnox]

Youre welcome bro.

Up for the supper crowd.

[MickeyKnox]

..Up for the supper crowd.

....

[MickeyKnox]

Bump..

[MickeyKnox]

Front page..

[MickeyKnox]

Pick one or the other and run them ON CYCLE, don't just keep them on hand.

[AnabolicDoc]

I came across this thread a few days ago but just recently got a chance to read the entire OP. It was a really nice read. Thanks for taking the time to post it.

[MickeyKnox]

You're welcome Doc, thanks for the support.

[emp]

am i allowed to bump this?

[MickeyKnox]

am i allowed to bump this?

Absolutely!

[emp]

nice. my interest in trying to control sides and make things as safe as possible(not go about it and say, "it prob wont happen to me"), has greatly increased with a lot of ur posts!

i have no idea why im sucking up to u right now, but i just felt like u deserved some credit

keep up

[MickeyKnox]

Thanks for the support Emp, and I appreciate your comments.

This is a terrific Board with a ton of educated members collectively gathered together with the same goals in mind - your health.

I hope you stick around end educate yourself so that you don't end up a negative stat.

Cheers!

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[jimmyinkedup]

Mick you should add in the benefit of taking Stane with dietary fats. 40% increased absorption.

[MickeyKnox]

Mick you should add in the benefit of taking Stane with dietary fats. 40% increased absorption.

Funny you point that out. Ive come across that a couple of times as well, but i have yet to locate any clinical data supporting it. Im not suggestion it doesn't exist, just that i haven't yet found anything - I wish i could.

Do you have anything i can read Jimmy? If i can dig something up concrete i will definitely include it along with a link to support the claim.

[jimmyinkedup]

Funny you point that out. Ive come across that a couple of times as well, but i have yet to locate any clinical data supporting it. Im not suggestion it doesn't exist, just that i haven't yet found anything - I wish i could.

Do you have anything i can read Jimmy? If i can dig something up concrete i will definitely include it along with a link to support the claim.

I got it buddy.
http://www.accessdata.fda.gov/drugsa...in_medr_P1.pdf
http://www.accessdata.fda.gov/drugsa...opharmr_P1.pdf
and a study
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201097/

[BBrian]

Thanks for taking the time to outline these details Mick. Based on this data I actually find Aromasin to be more attractive than Arimidex , although it appears to be important to begin administering Aromasin earlier to avoid an initial spike in estrogen early in the cycle. One thing I wanted to inquire about, though, are these two statements;

"Aromasin not only increases testosterone and lowers estrogen, but it also increases levels of insulin -like growth Factor (IGF)"

"The following observations were made:
1. Plasma lipids and IGF-I concentrations were unaffected by treatment."

Which is true, or did two separate studies come to two different conclusions regarding Aromasin?

[jimmyinkedup]

Thanks for taking the time to outline these details Mick. Based on this data I actually find Aromasin to be more attractive than Arimidex , although it appears to be important to begin administering Aromasin earlier to avoid an initial spike in estrogen early in the cycle. One thing I wanted to inquire about, though, are these two statements;

"Aromasin not only increases testosterone and lowers estrogen, but it also increases levels of insulin -like growth Factor (IGF)"

"The following observations were made:
1. Plasma lipids and IGF-I concentrations were unaffected by treatment."

Which is true, or did two separate studies come to two different conclusions regarding Aromasin?

Where have you been hiding? Good to see you around man.

[BBrian]

Where have you been hiding? Good to see you around man.

I was hiding in the mountains for a while, away from civilization and internet.
Thanks for the welcome man, it's great to be back.

[Synergy1]

Mickey, you make my time on this forum much easier. For the past few days I've been reading up on both---and for some GD reason, I never came across this thread until this morning. You have a knack for posting info that is easily discernible, backed with facts. I work with the human body everyday and its nice to have a source to find legit info on areas I know nothing about. Just wanted to let you know its appreciated. I have browsed a few other sites and i'm telling you.....some of the guys/gals here almost have a PhD compared to the garbage they go off of.

[MickeyKnox]

Thanks for taking the time to outline these details Mick. Based on this data I actually find Aromasin to be more attractive than Arimidex , although it appears to be important to begin administering Aromasin earlier to avoid an initial spike in estrogen early in the cycle. One thing I wanted to inquire about, though, are these two statements;

"Aromasin not only increases testosterone and lowers estrogen, but it also increases levels of insulin -like growth Factor (IGF)"

"The following observations were made:
1. Plasma lipids and IGF-I concentrations were unaffected by treatment."

Which is true, or did two separate studies come to two different conclusions regarding Aromasin?

The first study concluded that it increased IGF. But noted "...there have been some additional researches related to Aromasin in men in pharmacokinetics."

The second study IS the PK study that was referenced. Its from the University Of Florida. Re: Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males.

I was attempting illustrate that the increase in IGF is not conclusive. Perhaps i should, have attached a note. My apologies for the confusion Brian.

Mickey, you make my time on this forum much easier. For the past few days I've been reading up on both---and for some GD reason, I never came across this thread until this morning. You have a knack for posting info that is easily discernible, backed with facts. I work with the human body everyday and its nice to have a source to find legit info on areas I know nothing about. Just wanted to let you know its appreciated. I have browsed a few other sites and i'm telling you.....some of the guys/gals here almost have a PhD compared to the garbage they go off of.

Thanks Synergy.

And i have to agree, this site is packed with knowledgeable members who's primary concern is the health and well being of its membership. It is, without a doubt, the Premiere of all the AAS sites and im proud to play a small role.

[jimmyinkedup]

The first study concluded that it increased IGF. But noted "...there have been some additional researches related to Aromasin in men in pharmacokinetics."

The second study IS the PK study that was referenced. Its from the University Of Florida. Re: Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males.

I was attempting illustrate that the increase in IGF is not conclusive. Perhaps i should, have attached a note. My apologies for the confusion Brian.

Eh the main point - which you did convey is that there is not an adverse impact on igf. Based on the relationship between estrogen and igf and igf an er upregulation the simple fact that we can manage estrogen without an adverse impact on igf is huge and the main consideration. Any increase I have seen in studies with ai's where one is claimed is really clinically insignificant. You nailed the important part.

[MickeyKnox]

I got it buddy.
http://www.accessdata.fda.gov/drugsa...in_medr_P1.pdf This study is inconclusive because the biovailability in humans was not possible "due to the absence of a suitable intravenous formulation." However there is indirect evidence to support otherwise. So i agree, it's worth noting.
http://www.accessdata.fda.gov/drugsa...ne yet.</font>
and a study
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201097/ This study was performed on women and Aromasin has been shown through clinical data to behave differently in Men.

I just got around to taking a look at these Jimmy. Thanks!

[MickeyKnox]

Eh the main point - which you did convey is that there is not an adverse impact on igf. Based on the relationship between estrogen and igf and igf an er upregulation the simple fact that we can manage estrogen without an adverse impact on igf is huge and the main consideration. Any increase I have seen in studies with ai's where one is claimed is really clinically insignificant. You nailed the important part.

Do i get a little sticky star? Ha

[emp]

would u say starting aromasin one week after first injections of tren hex and testP to be too late? 266mg ew and 175mg ew, respectably.

ill edit the post if its not relevant to the aro-ari topic. was intended as a bump anyways

[jimmyinkedup]

I just got around to taking a look at these Jimmy. Thanks!

NP buddy!

[Ole kristian]

Great post! keep on writing mickeyknox!
I realy like that you use references in your posts.

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[tarmyg]

Good read indeed!

[1gearhead]

Good read indeed.... I use ai off cycle as well as when on....

[MickeyKnox]

Good read indeed.... I use ai off cycle as well as when on....

Really? Interesting..tell me more, if you don't mind sharing. Thanks.

[kawika]

Really? Interesting..tell me more, if you don't mind sharing. Thanks.

Seconded. I'm interested as well

[TheClinch]

Good read indeed.... I use ai off cycle as well as when on....

First, this is a great thread. I've been subscribed since the beginning and it is full of great info so thank you.

Second, 1gearhead you have my attention as well, please do share why. It's an interesting concept and i'd like to hear more.

[kawika]

And Mickey. Excellent read. I saw this post a few days ago and just finally had a chance to go through it.

Did you find any info on the dose of adex that caused the estrogen rebound? do you think tapering may be helpful to negate that affect? Or are the doses used by the aas community to low to see significant estrogen rebound while on adex.

[emp]

lost count as to how many times ive been on this thread and quoted u on other forums now...im constantly finding new material to teach the young ones.

ofc, im taking all the credit, thank u very much

[MickeyKnox]

And Mickey. Excellent read. I saw this post a few days ago and just finally had a chance to go through it.

Did you find any info on the dose of adex that caused the estrogen rebound? do you think tapering may be helpful to negate that affect? Or are the doses used by the aas community to low to see significant estrogen rebound while on adex.

No i haven't but i think tapering is necessary. Tapering only prolongs the inevitable or the end game. I dont taper at all. I DO however titrate doses up or down as a necessary evil to control E2, but that's where i draw the line.

lost count as to how many times ive been on this thread and quoted u on other forums now...im constantly finding new material to teach the young ones.

ofc, im taking all the credit, thank u very much

Im just glad you're able to share the info put it to good use.

[MickeyKnox]

Bump..

[AlinSR]

I'm taking them both right now.