*Aromasin (Exemestane) vs Arimidex (Anastrozole) Unraveled*

[MickeyKnox]

I'm taking them both right now.

Can you elaborate on this please? What is your current protocol and what do you expect to accomplish?

For information only. Thank you.

[emp]

bumpyyy ride

[boz]

Top read, im going to read this over and over again, and drill it into me i have a bad tendency of neglecting my e2.

Thanks mikey!

[MickeyKnox]

Top read, im going to read this over and over again, and drill it into me i have a bad tendency of neglecting my e2.

Thanks mikey!

Youre welcome. And it's Micky, not mikey..lol

Shameless bump..

[MickeyKnox]

Bum,p..

[kawasaki]

great info i mite be wrong but i found Exemestane for 30 pills is close to $250 wow , i know pills are not the best , is there a better place to get this ---Aromasin ®
Active Ingredient: Exemestane
Manufacturer: Pharmacia & Upjohn SpA
Aromasin is the newest and possibly best aromatase inhibitor available.
According to medical studies, Aromasin may be the only aromatase inhibitor that does not negatively affect one's cholesterol profile. That's a huge advantage over aromatase inhibitors such as Arimidex and Femara which are notorious for devastating lipid profiles, raising the bad cholesterol (LDL) while lowering the good cholesterol (HDL). It is interesting to note that although Aromasin seems to be the most potent among all anti aromatases, it is the one with the least reported side effects if any.

Note that anti aromatases (Aromasin, Femara, Arimidex) are often confused with anti estrogens (Nolvadex ). Anti aromatases work quite differently than anti estrogens do. Anti estrogens are actually weak estrogens that attach to the estrogen receptor sites in the body (such as the nipple and breast area), by doing so they block the 'bad' estrogens from attaching to these sites. Anti aromatases on the other hand block the formation of estrogen in the body in the first place. They do this, by blocking the enzyme aromatase which is responsible for the conversion of testosterone to estrogen, so there is less estrogen circulating in the blood. In a sense, an anti aromatase such as Aromasin takes care of the problem right from it's root.

[MickeyKnox]

great info i mite be wrong but i found Exemestane for 30 pills is close to $250 wow , i know pills are not the best , is there a better place to get this ---Aromasin ® Edit the dollar figures out of your post. Youre setting yourself up as a target to be ripped off.
Active Ingredient: Exemestane
Manufacturer: Pharmacia & Upjohn SpA
Aromasin is the newest and possibly best aromatase inhibitor available. According to who?
According to medical studies, Aromasin may be the only aromatase inhibitor that does not negatively affect one's cholesterol profile. Can you please post up these medical studies so that we may all read them and formulate our own opinion based on clinical data. Thanks. That's a huge advantage over aromatase inhibitors such as Arimidex and Femara which are notorious for devastating lipid profiles, raising the bad cholesterol (LDL) while lowering the good cholesterol (HDL). Wow, id really like to see this substantiated as well. Thanks It is interesting to note that although Aromasin seems to be the most potent among all anti aromatases, Really? Its the most potent? If you mean its a steroidal aromatase inactivator, then yes i agree. But once again, a link to support these claims would be appreciated. Thanks. it is the one with the least reported side effects if any. I disagree, only because you are focused on the LDL/HDL propaganda and parroting the perils of Stane - im not buying into that, sorry. Again, you'll have to provide clinical data to support this claim.

Note that anti aromatases (Aromasin, Femara, Arimidex) are often confused with anti estrogens (Nolvadex ). Anti aromatases work quite differently than anti estrogens do. Anti estrogens are actually weak estrogens that attach to the estrogen receptor sites in the body (such as the nipple and breast area), by doing so they block the 'bad' estrogens from attaching to these sites. Can you elaborate on these "bad" estrogens please? Anti aromatases on the other hand block the formation of estrogen in the body in the first place. They do this, by blocking the enzyme aromatase which is responsible for the conversion of testosterone to estrogen, so there is less estrogen circulating in the blood. In a sense, an anti aromatase such as Aromasin takes care of the problem right from it's root.

Bottom line is, one is a Selective Estrogen Receptor Modulator (SERM) and one is an Aromatase Inhibitor (AI). They play different roles, although similar behaviour expression can be recorded as Aromasin is known to raise testosterone levels by 60%. A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.Br J Clinical Pharmacology. 2005 Mar, 59(3):355-64.

[MickeyKnox]

Bump..

[kawika]

Can we make this a sticky?

[emp]

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[Java Man]

Excellen post MK. Thank you. I've been reading up on this subject as I am old school... Ai is new in my world. I vote sticky too even though I haven't said hello to enough new members to be knowledgeable yet.

[MickeyKnox]

You're welcome.

(shameless bump)

[MickeyKnox]

Bump..

[jimmyinkedup]

Mick Id like to throw something out there. If we look at the primary study on males and stane we see that the difference in effect from 25 to 50mg daily is very little. Also we note hat at both doses although e2 is significantly dropped it remains in the low end of the clinically acceptable range What am I getting at? I think we are under-dosing exemestane. Also based on the data mentioned above it is very hard to "crush" e2 levels with exemestane. Im starting to think 12.5ed is the minimum and in fact 25mg/day might very well be the optimal therapeutic dose for our purposes. Thoughts ?

[MickeyKnox]

Mick Id like to throw something out there. If we look at the primary study on males and stane we see that the difference in effect from 25 to 50mg daily is very little. Also we note hat at both doses although e2 is significantly dropped it remains in the low end of the clinically acceptable range What am I getting at? I think we are under-dosing exemestane. Also based on the data mentioned above it is very hard to "crush" e2 levels with exemestane. Im starting to think 12.5ed is the minimum and in fact 25mg/day might very well be the optimal therapeutic dose for our purposes. Thoughts ?

Thats funny you just mentioned this Jimmy. You want my honest opinion? I should have conferred with you on this, but the 10mg/day has been eating my brain out ever since i wrote it.

Why? Simply because i REALLY believe that the daily dose should be higher, but i didn't have the balls to write. I hate myself for that. I should stand behind what i KNOW is right. But im so afraid of hurting someone by suggesting a dose that may cause E2 issues. Thats why i get pissed off fast when someone suggests something stupid (irresponsible advice from a lack of experience or knowledge) to a new member.

I totally agree with you bro and im super pleased that you brought this up! 12.5mg/day minimum, or even higher, would be better suited for our needs as AAS users. With a 9 hour half life in MEN, it only makes sense.

However i do honestly think that 25mg/day would be the high end of the spectrum - this is base on my own experience late last year when i was experimenting with it. I did actually use 25mg/day for several days but then reverted back to 12.5mg/day. What do you think?

And thanks again for bringing this up man - its the push i needed!

[tinytony]

Thats funny you just mentioned this Jimmy. You want my honest opinion? I should have conferred with you on this, but the 10mg/day has been eating my brain out ever since i wrote it.

Why? Simply because i REALLY believe that the daily dose should be higher, but i didn't have the balls to write. I hate myself for that. I should stand behind what i KNOW is right. But im so afraid of hurting someone by suggesting a dose that may cause E2 issues. Thats why i get pissed off fast when someone suggests something stupid (irresponsible advice from a lack of experience or knowledge) to a new member.

I totally agree with you bro and im super pleased that you brought this up! 12.5mg/day minimum, or even higher, would be better suited for our needs as AAS users. With a 9 hour half life in MEN, it only makes sense.

However i do honestly think that 25mg/day would be the high end of the spectrum - this is base on my own experience late last year when i was experimenting with it. I did actually use 25mg/day for several days but then reverted back to 12.5mg/day. What do you think?

And thanks again for bringing this up man - its the push i needed!

Can Exemestane be used to much effect in reducing gyno symptoms? Like a pinhead sized lump?

[MickeyKnox]

Can stamens be used to much effect in reducing gyno symptoms? Like a pinhead sized lump?

Welcome to the Forums!

Please post any of your AAS questions, including stats, in the Q&A Anabolic Forum for a better response and more traffic. This will enable others to view and respond as well.

Thanks!

Anabolic Q&A Forum.

http://forums.steroid.com/forumdispl...S#.UIDcDq7X_fs

[emp]

ey mickey, i did what u said, 25mg ed for 72 hours, and im feeling much better. my nipps were kinda getting sensitive, and they went back to being better than ever...im planning on going back to 25mg eod again, or maybe ill buy another batch of the stane with 12.5mg caps this time. i know i need it ED! but ill be trying to go back to 25mg eod, and ill let u know how it works out.

and i think we can say my stane isnt bunk, which is a relief BW in a couple of weeks to know for sure

thx MK, always there to give great advise

[jimmyinkedup]

Thats funny you just mentioned this Jimmy. You want my honest opinion? I should have conferred with you on this, but the 10mg/day has been eating my brain out ever since i wrote it.

Why? Simply because i REALLY believe that the daily dose should be higher, but i didn't have the balls to write. I hate myself for that. I should stand behind what i KNOW is right. But im so afraid of hurting someone by suggesting a dose that may cause E2 issues. Thats why i get pissed off fast when someone suggests something stupid (irresponsible advice from a lack of experience or knowledge) to a new member.

I totally agree with you bro and im super pleased that you brought this up! 12.5mg/day minimum, or even higher, would be better suited for our needs as AAS users. With a 9 hour half life in MEN, it only makes sense.

However i do honestly think that 25mg/day would be the high end of the spectrum - this is base on my own experience late last year when i was experimenting with it. I did actually use 25mg/day for several days but then reverted back to 12.5mg/day. What do you think?

And thanks again for bringing this up man - its the push i needed!

Im thinking in going to run it at 12.5ed as a starting point when on next and get some bloodwork - see what that yields for me personally, however I am strongly leaning towards that being the starting dose as well. I want to try to substantiate it personally however. It has been nagging at me as well Mick -thus my post.

[largerthannormal]

This is an awesome write up Mick, DEF STICKY

I was googling for hours last week on this topic, I didnt see this write up until this morning.

So glad i went with Aromasin !!

Also glad you brought up the half life and the topic you and Jimmy spoke of about minimum dosing,

I too will start at 12.5 ED

Great read!!!

[blake170]

Yet another good point for newbies (like me); the longer we wait, and the more reading/research we do; the more information becomes available. I guess the patience that comes with being 41 is of value in this area. (Now I know why my Pops always told me, "Youth is wasted on the young.)

[oatmeal69]

Thanks Mickey, outstanding thread!! Subscribed.

[MickeyKnox]

Im super happy that this article has helped so many. Youre very welcome guys.

Im thinking in going to run it at 12.5ed as a starting point when on next and get some bloodwork - see what that yields for me personally, however I am strongly leaning towards that being the starting dose as well. I want to try to substantiate it personally however. It has been nagging at me as well Mick -thus my post.

Im going to change up my protocols in this thread and the Common Beginners Thread immediately.

[MickeyKnox]

Bump..

[MickeyKnox]

Bump..

[dumpslugzz]

great post

[oatmeal69]

I'm about 4 days into my new cycle. I'm going to wait the first week, and then start 12.5 mG/ed Aromasin . Do you think this is all right, or should I be using it from the very beginning?

[MickeyKnox]

From the beginning, especially with short esters. Aromasin takes about a wk to spool up.

[MickeyKnox]

Bum,p..

[largerthannormal]

Sticky

[largerthannormal]

Mick with any of the studies you seen is there any chance of your e gettn to low?

[emp]

can u sticky a bump, on the bumpersticker?

[MickeyKnox]

Mick with any of the studies you seen is there any chance of your e gettn to low?

If you use too much AI it can get too low. Is that what you were asking?

[largerthannormal]

Yes basically , I will prolly start out at 12.5ed.. I just fear if I only get blood work half way thru I won't know whats going on

Honestly i had gyno growing up and had it surgically removed , they do take most the gland and have had a few cycles and I came to conclusion I'm not prone to gyno do to that "guessing"

So like an idiot i never ran an AI ever due to lack of knowledge,

I fear I won't recognize the signs if I get too low, in turn hinder gains,

On a side note gains in my cycles haven't been super awesome, after tons of research n prep I think the lack of an AI could be part culprate.

[MickeyKnox]

Yes basically , I will prolly start out at 12.5ed.. I just fear if I only get blood work half way thru I won't know whats going on

Honestly i had gyno growing up and had it surgically removed , they do take most the gland and have had a few cycles and I came to conclusion I'm not prone to gyno do to that "guessing"

So like an idiot i never ran an AI ever due to lack of knowledge,

I fear I won't recognize the signs if I get too low, in turn hinder gains,

On a side note gains in my cycles haven't been super awesome, after tons of research n prep I think the lack of an AI could be part culprate.

You may want to look at Adex then. Its a bit easier to control imho, and it works fairly fast. 25mg EOD wont crash you on cycle - adjust from there.

[Sgt. Hartman]

Thats funny you just mentioned this Jimmy. You want my honest opinion? I should have conferred with you on this, but the 10mg/day has been eating my brain out ever since i wrote it.

Why? Simply because i REALLY believe that the daily dose should be higher, but i didn't have the balls to write. I hate myself for that. I should stand behind what i KNOW is right. But im so afraid of hurting someone by suggesting a dose that may cause E2 issues. Thats why i get pissed off fast when someone suggests something stupid (irresponsible advice from a lack of experience or knowledge) to a new member.

I totally agree with you bro and im super pleased that you brought this up! 12.5mg/day minimum, or even higher, would be better suited for our needs as AAS users. With a 9 hour half life in MEN, it only makes sense.

However i do honestly think that 25mg/day would be the high end of the spectrum - this is base on my own experience late last year when i was experimenting with it. I did actually use 25mg/day for several days but then reverted back to 12.5mg/day. What do you think?

And thanks again for bringing this up man - its the push i needed!

I run 25mg on cycle and have still seen BW with high e2 levels. Obviously its cycle dependent and it's never been stupid high but has been above ref range at 25mg.