Chinese HGH concerns

[DanB]

but, but the guy in the coat had a beaker in his hand.
There are a million "sites" for jins. Even when you could order jins easily it wasnt threw a website.

hey my site is legit they even have a pic of a lab report, they have pharm tren and hcg pills too, I get a discount for return customer so send me your cash we split an order

I wasnt around when jins first came on scene but I doubt any legit pharm no matter what country they based in can openly advertise to sell something illegal unless of course it legal in that country and then ship to legal countrys only but even then it gets a grey area and closer to what happened to gensci and ruined the jins for you, even the paki's cant get away with that one, and they do virtually everything up to that point, you prob know yourself.........

[ChuckEisenmench]

I am curious how someone with all your knowhow would not buy generic HGH. The brand names have markups that are very high. Brand names are always more expensive due to the years of r&d and testing and regs. When you go to your pharmacy be sure to not get any generic drug prescriped by your Dr. , instead insist on brand names only. I always get the generic because of the much lower price of a generic. They only have to use the production methods already developed by big co.s that have spent millions on development.

[gixxerboy1]

I am curious how someone with all your knowhow would not buy generic HGH. The brand names have markups that are very high. Brand names are always more expensive due to the years of r&d and testing and regs. When you go to your pharmacy be sure to not get any generic drug prescriped by your Dr. , instead insist on brand names only. I always get the generic because of the much lower price of a generic. They only have to use the production methods already developed by big co.s that have spent millions on development.

your comparing apples and oranges.
The generics you get from a pharmacy are still licensed pharmaceutical company. The patent just rand out on the drug so other companies are a loud to make it.
The so called generic gh isnt made my a pharmaceutical company. Its an ugl. The equipment to produce bio available gh is millions. You can get around buying the proper equipment. Even if you understand how to make it you cant with out it.
Also that is why you see no generic gh in a pharmacy anyplace.

[BigBadWolf]

I am curious how someone with all your knowhow would not buy generic HGH. The brand names have markups that are very high. Brand names are always more expensive due to the years of r&d and testing and regs. When you go to your pharmacy be sure to not get any generic drug prescriped by your Dr. , instead insist on brand names only. I always get the generic because of the much lower price of a generic. They only have to use the production methods already developed by big co.s that have spent millions on development.

Do you have a learning disorder? It's to expensive to make. there are no generics. Buy what you want. no one care if you don't.

[RoadToHuge]

What is the process for non boi available hgh? I do not know much but it seems to me that you are saying there is a short cut can be made that makes it cheaper, still show up on a test as HGH but not bioavailable. If people are taking it and getting sides, blood tests with elevated hgh, etc. You are telling me that there is a short cut that is being taken that some how makes it unavailable. I have an understanding on how it is made, and do not unerstand the shortcut they could be making, and if they did the "million dollar" equiptment you are mentioning is still being used. It just does not all compute, but I am sure you have a clear understanding so please tell me what I am missing. I do not doubt that generic hgh has less actual hgh and the method may be much cruder, but you bio availablity arguement as well as you saying that its something other than hgh, but it still shows up on a blood test as hgh is confusing to me. TIA

[Sgt. Hartman]

Here's what you're asking for - copied from an old thread I made a while back.


*** GH Testing ***
There's always a lot of talk on here about people wanting to get their GH tested and recently another board has posted results of several generic GH brands that they paid to have tested at a licensed US facility.

The problem with giving these tests any credibility is that there currently isn't a proper method of testing a recombinant protein based drug for "biological activity". In other words it could test to be pure 191aa GH and have absolutely none of the desired effect when administered. This article is written by Boris Y. Zaslavsky, Department of Physiology and Biophysics, Cornell University Medical College.




Recombinant DNA (rDNA) technology has led to the development of new protein-based drugs that are gaining worldwide regulatory approval. Human growth hormone , human insulin , β- and γ-interferons, and erythropoietin are just a few examples of approved rDNA-derived biopharmaceuticals.

The biological effects, purity, and potency of a drug is governed by the chemical structure of the drug for both traditional drugs and biopharmaceuticals. Standard analytical methodologies used for structural analysis of conventional drugs are, however, inadequate for complete characterization of protein-based products.

Two main reasons for this inadequacy are the large molecular size and conformational flexibility of protein-based drugs. The large molecular size hinders the possibility to detect, for example, repla***ent or chemical modification of a single amino acid residue or a change in a single glycosylation site. These alterations of the biomolecule structure, however, may lead to subtle changes of the molecule conformation resulting in significant changes in the pharmacological properties of the product.

Additionally, the wrong choice of manufacturing conditions or formulation may lead to improperly folded polypeptide chains which are biologically inactive. Hence, further methodologies capable of analysis of the protein conformation are needed.

Currently, the analysis of biopharmaceuticals relies heavily on the use of sophisticated methods for the demonstration of the structural identity, homogeneity and purity of the products. These methods include amino acid and carbohydrate analysis, N- and C-terminal sequence analysis, spectroscopic (UV, CD, ORD) analysis, peptide mapping, electrophoresis, chromatographic purity profile methods, potency/activity assays, etc. It must be emphasized that no one method is considered to be sufficient in itself, and that multiple methods are necessary to completely characterize and/or control such products.

For example, amino acid analysis for proteins with molecular weights above about 16 kilodaltons is known to be of very limited value. While useful for identification of the target protein, N-terminal and C-terminal sequencing only partially characterize the protein. Analysis of the primary structure, however, is insufficient to assure the biological potency of a protein, particularly since the potency depends on the protein conformation.

The conformation of proteins is usually analyzed by optical spectroscopy, such as UV spectroscopy, fluorescence spectroscopy, optical rotary dispersion, or circular dichroism. These methods are generally not sensitive enough to detect the subtle conformational changes caused by small alterations in the protein structure, especially if these changes do not affect side-chain chromophores from tryptophan, phenylalanine, tyrosine, and cysteine residues within the protein. Furthermore, these methods as well as others, such as electrophoresis, isoelectric focusing, differential scanning calorimetry, light scattering, ultracentrifugation, gel filtration, and immunological assays, only provide information about a particular structural or functional feature of a protein.

Chromatography is currently the most widely used analytical method for determining the purity of small organic drugs. Four modes of High-Performance Liquid Chromatography (HPLC) currently used for protein analysis are size-exclusion, ion-exchange, reversed-phase, and hydrophobic interaction chromatography. All these HPLC methods, though commonly employed to monitor the purity of biopharmaceuticals, are usually incapable of resolving proteins that differ by one or two residues or detecting other small changes in the macromolecular structure.

Hence, while chromatography is sufficient for determining whether a small organic drug is functional, the evaluation of a biopharmaceutical requires measurements of biological activity. Many of these measurements are the animal-based assays, particularly when the mechanism of action of the biopharmaceutical is not well defined. These assays are generally imprecise (with variability often 30% to 100%), time-consuming, and costly, and are not rugged. Cell culture assays can be used when the protein-based drug produces a measurable response in a cell-based system. The variability of these assays is much lower, often in the range of 10% to 30% or better (e.g., in vitro clot lysis assay has a variability of about 5%).

Physicochemical tests are much faster, more precise, and more reliable than biological assays. A physicochemical test providing information related to the biological potency of a protein-based drug would improve the control of the safety and efficacy of the drug.

Such a test should meet the following requirements: (1) it should provide information quantitatively related to the biological potency of a biopharmaceutical, (2) it should be capable of detecting minor changes in the structure of large macromolecules, (3) it should be especially sensitive to the structural changes affecting the efficacy of a biomacromolecule, (4) it should be sensitive to the presence of impurities in the product in quantities as small as 0.1 to 0.01 wt. %, (5) it should be simple, precise, and rugged, and (6) it should be time-, labor-, and cost-effective so as not to increase the overall cost of the product. Even if only some of these requirements were met, the test would improve the possibilities for assuring the safety and efficacy of biopharmaceuticals, such as recombinant human growth hormone (rhGH).





And this is a post from Marcus' "associate" stating basically the same thing.

I do know someone who I am in contact with and in one of his first emails to me he describes the process of testing this horomone. I will copy the email so you get more of an understanding. My contact has many titles, he is a Professor of research, Scientific manager, he is head of the Biopharmaceutical Bioprocessing technology centre, Director of Mass spectrometry in clinical pharmacology who provide protein analysis services to commercial and academic clients and also a Doctor.



Hi Marcus,


there are some things that we can do, some things that we could do, but that would possibly be too expensive (not worth it) and other things that we cannot do.


Please let me start with the last section:


We absolutely cannot test any substances for their suitability for any purpose, particularly not for their use in a diagnostic, therapeutic and/or recreational purpose, when this invloves administering to a living being (including humans).


Measuring the concentration of the growth hormones is something that is actually not as easy as it might seem. The concentration of the hormone can have two different meanings, it could be the chemical concentration of a compound (this is something that we can measure), it could also be the biological activity of this compound (this would be different, if a certain proportion of this chemical would be biologically inactive, which could happen for a variety of reasons). The latter (measuring the biological activity) is something we cannot do. We can measure the chemical concentration of human growth hormone (or any other growth hormone ), but that would involve the chemical synthesis of an internal standard, followed by a fairly complicated experiment, in which we use chemical scissors (en enzyme called trypsin) to chop the protein into pieces, then we analyse these pieces using a combination of high performance liquid chromatography and mass spectrometry, followed by a computer-intensive analysis of the data. The result of this experiment would be the concentration either in units of mol/l or in units of mg/l (the two are interconvertible). I do not know how the IU (stands for International Units) for growth hormone are defined - this might be a functional (biological) unit (which we cannot measure).


Human growth hormone is a chain of 191 different amino acids. One thing we can do is measure the total molecular weight of the protein in a sample to see, if it corresponds to the molecular weight that would be predicted for a protein containing these 191 amino acids. This experiment detects, if one amino acid was missing or another one was added, in some cases (but not in all cases) even, if an amino acid was replaced with a different one. Another outcome of this experiment would be to see, if other, similar proteins are present in the same sample.


In a different experiment we can check, if a protein in a particular sample is really growth hormone or if it is possibly something completely different, for example egg white protein or milk protein .


For your information, I attach two links to articles about human growth hormone :



Best Wishes

[ChuckEisenmench]

Do you have a learning disorder? It's to expensive to make. there are no generics. Buy what you want. no one care if you don't.

I went online using the internet and researched Chinese Pharmacutical manufacturers. There I found the list contained co.s making many chemicals that are not available to any UGL. They have the money and equipment to produce any FDA (and Chinese Govt. agencys) certified pharmacutical
compound. I contacted the factory's manager of one of these and I received confirmation through his quality control manager that at a reasonable price they have a source of HGH. The number of Chinese Pharm. co.s that are legitimate sources of medical formulas and medicinal products is legion.
On another tact, how about IGF-1 and the other peptides? Are they also generic fakes? And of what use are HGH supplements? The co I contacted had 100's of employees. If bioavailibilty cannot be tested (as per the above Dr.s text, how can the name brands be proven effective?
"We absolutely cannot test any substance for their suitability for any purpose, particularly not for their use in a diagnostic, therapeutic and or recreational purpose when this involves administering to a human being."

[gixxerboy1]

I went online using the internet and researched Chinese Pharmacutical manufacturers. There I found the list contained co.s making many chemicals that are not available to any UGL. They have the money and equipment to produce any FDA (and Chinese Govt. agencys) certified pharmacutical
compound. I contacted the factory's manager of one of these and I received confirmation through his quality control manager that at a reasonable price they have a source of HGH. The number of Chinese Pharm. co.s that are legitimate sources of medical formulas and medicinal products is legion.
On another tact, how about IGF-1 and the other peptides? Are they also generic fakes? And of what use are HGH supplements? The co I contacted had 100's of employees. If bioavailibilty cannot be tested (as per the above Dr.s text, how can the name brands be proven effective?
"We absolutely cannot test any substance for their suitability for any purpose, particularly not for their use in a diagnostic, therapeutic and or recreational purpose when this involves administering to a human being."

you seriously are a sucker. Yea a pharmaceutical company has a "source" for you for gh. Go for it. I'm sure your intesinve research is much more then the guys who have been doing this for 10+ years, went down the same road you are and tried stuff. But im sure your different. You will get real gh.

[ChuckEisenmench]

With a blood serum HGH test you know that the stuff is not an AI, HCG , or any other pharmacutical.
The bioavailibility issue is a question that is answered by the fact that the BW shows a definate pharmacutical product that requires the same expensive equipment to produce as real HGH. Now the sides are felt by me that also help determine the effectiveness.

[gixxerboy1]

With a blood serum HGH test you know that the stuff is not an AI, HCG , or any other pharmacutical.
The bioavailibility issue is a question that is answered by the fact that the BW shows a definate pharmacutical product that requires the same expensive equipment to produce as real HGH. Now the sides are felt by me that also help determine the effectiveness.

how do you know its not a peptide?
No offense but people who have been in the game alot longer have better contacts then you all know its garbage.Use what you want. It your money you are throwing away
i love how sides tell you its real. I use straight from the pharm 5iu ed and dont get sides besides some water retention.

[Times Roman]

how do you know its not a peptide?
No offense but people who have been in the game alot longer have better contacts then you all know its garbage.Use what you want. It your money you are throwing away
i love how sides tell you its real. I use straight from the pharm 5iu ed and dont get sides besides some water retention.

this is why i've stayed away from HGH so far. Unless you know someone that can refer you to a legit HGH supplier, chances of buying bogus are almost assured

[ChuckEisenmench]

Well I guess I'll use up the crap I got and see if 5iu/day does anything on the scale or in the gym. I should see some results hopefully after a few months.

[Sgt. Hartman]

Well I guess I'll use up the CRAP I got and see if 5iu/day does anything on the scale or in the gym. I should see some results hopefully after a few months.

^^^Smartest thing I've seen you post yet.

[EasyDoesIt]

^^^Smartest thing I've seen you post yet.

Hopefully not damaging Crap!

[Sgt. Hartman]

Hopefully not damaging Crap!

Exactly. Some of us have used the chinese generics and it's fvcked us up........

[BigBadWolf]

Well I guess I'll use up the crap I got and see if 5iu/day does anything on the scale or in the gym. I should see some results hopefully after a few months.

There is no way I would use something I had no idea what it was for a few months. That's foolish.

[Times Roman]

Well I guess I'll use up the crap I got and see if 5iu/day does anything on the scale or in the gym. I should see some results hopefully after a few months.

I've talked to blokes that have been on as low as 1iu pharma grade, and said they could really tell the difference.

I'd suggest that if you do NOT know what you are injecting into YOUR body, it might not be a good idea to inject it in the first place?

just my .02 mate

[EasyDoesIt]

I've talked to blokes that have been on as low as 1iu pharma grade, and said they could really tell the difference.

I'd suggest that if you do NOT know what you are injecting into YOUR body, it might not be a good idea to inject it in the first place?

just my .02 mate

The crap Jin I had screwed with my blood sugar, made me retain water terribly and whatever else I didn't know about. Using 2iu pharmacy grade is an amazing difference. When you use pharmacy grade you will know its working. The Jin has matching codes and all the right appearance, but was junk. Prob as stated by someone else I'd say it's worth setting up sites specially designed for junk that's made for U.S. for multi million dollar business. Or maybe made here, who knows.

[gixxerboy1]

^^^ gh will mess with your blood sugar. gh causes insulin resistance

[EasyDoesIt]

^^^ gh will mess with your blood sugar. gh causes insulin resistance

This was more severe than anything in past. Within 20 minutes of injecting, severe sweats, shaking and hungry even tho I just ate.

[gixxerboy1]

This was more severe than anything in past. Within 20 minutes of injecting, severe sweats, shaking and hungry even tho I just ate.

thats cause you had grhp 6, not gh. The symptom you mentioned are not insulin resistance

[EasyDoesIt]

thats cause you had grhp 6, not gh. The symptom you mentioned are not insulin resistance

Yup, I read it in the early stages of this thread. That's when everything added up to me as what the he... Is this shit.

[DanB]

thats cause you had grhp 6, not gh. The symptom you mentioned are not insulin resistance

damn that not even a good fake lol, most generics moved on from peps a long time ago as you know yourself...........

[ChuckEisenmench]

The crap Jin I had screwed with my blood sugar, made me retain water terribly and whatever else I didn't know about. Using 2iu pharmacy grade is an amazing difference. When you use pharmacy grade you will know its working. The Jin has matching codes and all the right appearance, but was junk. Prob as stated by someone else I'd say it's worth setting up sites specially designed for junk that's made for U.S. for multi million dollar business. Or maybe made here, who knows.

When you use pharmacy grade how do you know (in more detail) it's working? I am going to just wait and discontinue using the HGH? that I have.

[DanB]

You see it in mirror, I get an overall improved sense of well being for lack of a better way to put it into words, but others who use should understasnd me, people report better sleep although my sleep pattern is terrible due to lifestyle,

If its legit pharm then it is working, there is no 2 ways about it

[EasyDoesIt]

When you use pharmacy grade how do you know (in more detail) it's working? I am going to just wait and discontinue using the HGH? that I have.

For sure you see it in the mirror. Harder, more density in the muscle. Very forgiving when diet is not great, still stay lean and more defined. Hair grows Fast, skin looks better. The skin is obviously more noticeable the older you are. My work schedule and hours are terrible so I have not been able to benefit from the better rest. It continues to work better through continued use. I use only two units for anti aging purposes so gaining size is not there and not interested in getting big. When kicked up to 4iu's as I have done in the past the muscle density and vascularity increase is pretty amazing. Anyway that's my experience with it.

[Blergs]

May i have your source please mate...ive whittled mine down to two after 2 weeks of searching every day and discarding the ones that i have the slightest dubiousness about.. ive been offered igf1 lr3 at $ 80 10 vials*10 iu and water. would you like the site

Dude.... ar-r has IGF1 and its top quality.
Banner uptop.

[swithuk]

ive been on ansomone for a week now . (im sure its real as direct from manufacturer )
im using 4i.u daily in the evening.

interest to know what sides i will get and when they will start ?
nothing yet . although i feel abit more positive . i think and a bit more energy .... but this could be placebo

also interested to understand what the difference is between a genuine source of pharma grade g.h like ansomone from china
or from a big pharma co. in the states like lilly or pfizer prescribed ?
isnt real g.h real g.h no matter where its from ?

[Sgt. Hartman]

Lots of people don't get sides from 4iu, I don't really get any til i go over 5iu so maybe you're just lucky.

Yeah GH is real GH now matter who's company's name is on the vial. Imo real GH only comes from facilities that are licensed to produce GH, which Anke Bio is......

[gymsoldier]

Lots of people don't get sides from 4iu, I don't really get any til i go over 5iu so maybe you're just lucky.

Yeah GH is real GH now matter who's company's name is on the vial. Imo real GH only comes from facilities that are licensed to produce GH, which Anke Bio is......

PM sent.

[ChuckEisenmench]

I must have gotten lucky with the HGH I have because my hands feel like I have tight gloves on and energy and wellbeing is improved. Since this is the first time I have tried it after 30 years of going to gyms in DE, NJ and Fla. I must have received a real deal. With 45% of HGH being fake I guess there is a chance that you can get generic HGH from chinese pharms which is authentic. After a few more weeks I'll reorder and hope they still send me the same stuff. I'm a VET too! Have done several cycles of test bought through the internet and it definately was effective. Been ordering from the same site for 25 yrs. NO UGL lab crap.

[Angel of death]

Anke bio won't ship to the US tho right?

[DanB]

I must have gotten lucky with the HGH I have because my hands feel like I have tight gloves on and energy and wellbeing is improved. Since this is the first time I have tried it after 30 years of going to gyms in DE, NJ and Fla. I must have received a real deal. With 45% of HGH being fake I guess there is a chance that you can get generic HGH from chinese pharms which is authentic. After a few more weeks I'll reorder and hope they still send me the same stuff. I'm a VET too! Have done several cycles of test bought through the internet and it definately was effective. Been ordering from the same site for 25 yrs. NO UGL lab crap.

ok im confused

how do you know you have hgh and not something that mimics the sides without bloodwork

no site has operated for 25yrs that Im aware of so i call bullshit on that

where do you get 45% from? you just picked a number out of the sky so again i call bullshit and im sure staff will agree that the real figure is far higher

do you sell gh or rep for a source

[DanB]

Anke bio won't ship to the US tho right?

correct

[gixxerboy1]

ok im confused

how do you know you have hgh and not something that mimics the sides without bloodwork

no site has operated for 25yrs that Im aware of so i call bullshit on that

where do you get 45% from? you just picked a number out of the sky so again i call bullshit and im sure staff will agree that the real figure is far higher

do you sell gh or rep for a source

there wasnt even sites 25 years ago

[DanB]

there wasnt even sites 25 years ago

exactly what i was thinking

just waiting for somebody reputable like yourself to confirm it

[Sgt. Hartman]

I must have gotten lucky with the HGH I have because my hands feel like I have tight gloves on and energy and wellbeing is improved. Since this is the first time I have tried it after 30 years of going to gyms in DE, NJ and Fla. I must have received a real deal. With 45% of HGH being fake I guess there is a chance that you can get generic HGH from chinese pharms which is authentic. After a few more weeks I'll reorder and hope they still send me the same stuff. I'm a VET too! Have done several cycles of test bought through the internet and it definately was effective. Been ordering from the same site for 25 yrs. NO UGL lab crap.

Haven't you read the posts in this thread? The generic GH business does probably in the hundreds of millions of dollars a year so don't you think they could come up with something that would mimic the sides of GH without having to spend the millions of dollars on the equipment to produce the real thing.

I've taken generic that gave me CTS and made me retain water but did not elevate my IGF-1 levels at all......

[swithuk]

Anke bio won't ship to the US tho right?

yeah they wont ship to u.s
im in the u.k

[swithuk]

Lots of people don't get sides from 4iu, I don't really get any til i go over 5iu so maybe you're just lucky.

Yeah GH is real GH now matter who's company's name is on the vial. Imo real GH only comes from facilities that are licensed to produce GH, which Anke Bio is......

ok understood .thanks for your reply .
its only been a week so im not expecting much yet . ive not used g.h for a few years (since Chinese Olympics ) and ive missed it !

yeah there was no way i was going to use generics this time . i tried going down that road for a couple of months and its just a black hole thats sucks up your time and money ! (blue tops . not the yellows ! but if they have the spiral ..... !!! what a load of bollocks / nightmare !)
im in the u.k so i went with ansomone as they guarantee delivery or they resend - cant argue with that !

in your opinion when do you think i will notice positives or do you think i should up the dosage from 4i.u e.d ?

[ChuckEisenmench]

Ordered steriods in the 80's. Can't give you the source. They did HGH (90's) but not now. Jintropin was mailed then in the 90's and that is not bullshit. Yes there were websites in the 80's. I used test then, dianabol and deca . Ordered online, yes there were online sources in the 80's: period. Before you were even born.Available hgh include Nutropin, Hypertropin,Humatrope, Saizen, Serostim, Zorbtive, Nordtropin, Jintropin, Zomacton, all legit. Plus many other knockoffs that have the rescources to make it. It is not rocket science and can be produced just like the junk peptides that are similar to HGH, but not effective but require millions of dollars worth of equipment which contrary to some people is as difficult to make as the real thing. Anke bio makes 192 amino acid sequence. Ansomone.